Patents by Inventor Joelle DUBOIS

Joelle DUBOIS has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • “Multi-target” compounds with inhibitory activity towards histone deacetylases and tubulin polymerisation, for use in the treatment of cancer
    Patent number: 11014871
    Abstract: The present invention relates to the design of novel molecules, referred to as “multi-target” molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the “multi-target” molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one “multi-target” molecule, and the use of such compositions in the treatment of cancer.
    Type: Grant
    Filed: January 5, 2017
    Date of Patent: May 25, 2021
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUD
    Inventors: Mouâd Alami, Abdallah Hamze, Jean-Daniel Brion, Jérôme Bignon, Joëlle Dubois
  • Cytotoxic compounds which are inhibitors of the polymerisation of tubulin
    Patent number: 10653694
    Abstract: The invention relates to compounds which are inhibitors of the polymerization of tubulin, to the methods for the production thereof, and to the uses of same.
    Type: Grant
    Filed: April 9, 2015
    Date of Patent: May 19, 2020
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUD
    Inventors: Mouad Alami, Jean-Daniel Brion, Samir Messaoudi, Olivier Provot, Mohamed-Ali Soussi, Jerome Bignon, Joelle Dubois, Joanna Bakala-Wdzieczak
  • "MULTI-TARGET" COMPOUNDS WITH INHIBITORY ACTIVITY TOWARDS HISTONE DEACETYLASES AND TUBULIN POLYMERISATION, FOR USE IN THE TREATMENT OF CANCER
    Publication number: 20190023645
    Abstract: The present invention relates to the design of novel molecules, referred to as “multi-target” molecules, having a double pharmacophore and acting both as inhibitors of histone deacetylases (HDACs) and as inhibitors of tubulin polymerisation. The invention also describes the method for synthesising the “multi-target” molecules and their use in the treatment of cancer, a pharmaceutical composition comprising at least one “multi-target” molecule, and the use of such compositions in the treatment of cancer.
    Type: Application
    Filed: January 5, 2017
    Publication date: January 24, 2019
    Applicants: UNIVERSITE PARIS-SUD, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
    Inventors: Mouâd ALAMI, Abdallah HAMZE, Jean-Daniel BRION, Jérôme BIGNON, Joëlle DUBOIS
  • CYTOTOXIC COMPOUNDS WHICH ARE INHIBITORS OF THE POLYMERISATION OF TUBULIN
    Publication number: 20170035761
    Abstract: The invention relates to compounds which are inhibitors of the polymerization of tubulin, to the methods for the production thereof, and to the uses of same.
    Type: Application
    Filed: April 9, 2015
    Publication date: February 9, 2017
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE PARIS-SUD
    Inventors: Mouad ALAMI, Jean-Daniel BRION, Samir MESSAOUDI, Olivier PROVOT, Mohamed-Ali SOUSSI, Jerome BIGNON, Joelle DUBOIS, Joanna BAKALA-WDZIECZAK