Patents by Inventor Joelle Thonnard

Joelle Thonnard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Adult Liver Progenitor Cells for Treating Acute-On-Chronic Liver Failure
    Publication number: 20220143100
    Abstract: The invention relates to the use of a composition comprising human adult liver-derived progenitor cells, such as heterologous human adult liver-derived progenitor cells (HALPC), for the treatment of a patient who has developed acute-on-chronic liver failure (ACLF) or is at risk of developing ACLF, wherein the treatment comprises a step of administering to said patient an amount of said composition which comprises a dose of 0.25 to 2.5 million said progenitor cells per kg body weight; wherein the composition is substantially free of an effective amount of an anticoagulant, and wherein the patient does not receive any co-treatment with an anticoagulant.
    Type: Application
    Filed: March 26, 2020
    Publication date: May 12, 2022
    Inventors: Nancy Veulemans, Virginie Barthel, Etienne Sokal, Joëlle Thonnard, Nathalie Belmonte, Yelena Vainilovich
  • VACCINE COMPOSITION
    Publication number: 20160175423
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are characterized by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: March 2, 2016
    Publication date: June 23, 2016
    Inventors: Francois-Xavier Jacques BERTHET, Wilfried LJ DALEMANS, Philippe DENOEL, Joelle THONNARD, Christiane FERON, Jan POOLMAN, Georges THIRY, Pierre VOET, Yves LOBET, Guy DEQUESNE
  • VACCINE COMPOSITION
    Publication number: 20140294935
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: May 12, 2014
    Publication date: October 2, 2014
    Inventors: Francois-Xavier Jacques Berthet, Wilfried Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Yves Lobet, Jan Poolman, George Thiry, Joelle Thonnard, Pierre Voet
  • BASB 205 POLYPEPTIDES AND POLYNUCLEOTIDES FROM HAEMOPHILUS INFLUENZAE
    Publication number: 20110129475
    Abstract: The invention provides BASB205 polypeptides and polynucleotides encoding BASB205 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: September 27, 2010
    Publication date: June 2, 2011
    Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventor: Joelle Thonnard
  • BASB205 polypeptides and polynucleotides from
    Patent number: 7838003
    Abstract: The invention provides BASB205 polypeptides and polynucleotides encoding BASB205 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: November 23, 2010
    Assignee: GlaxoSmithKline Biologicals S.A.
    Inventor: Joelle Thonnard
  • outer membrane protein and use thereof in vaccination
    Patent number: 7811590
    Abstract: This invention relates to recombinant bacterial outer membrane proteins comprising one or more LB1(f) peptides from surface-exposed loop 3 of MOMP P5 of non-typeable H. influenzae. Polynucleotides encoding these recombinant proteins are also covered. The invention also relates to a method of isolating the recombinant proteins and a vaccine composition for use in the treatment of Haemophilus influenzae infection.
    Type: Grant
    Filed: December 20, 2007
    Date of Patent: October 12, 2010
    Assignees: The Ohio State University Research Foundation, GlaxoSmithKline
    Inventors: Lauren O. Bakaletz, Francois-Xavier Jacques Berthet, Philippe Denoel, Jan Poolman, Joelle Thonnard
  • BASB006 POLYPEPTIDES FROM NEISSERIA MENINGITIDIS AND IMMUNOGENIC COMPOSITIONS THEREOF
    Publication number: 20100196409
    Abstract: The invention provides BASB006 polypeptides and polynucleotides encoding BASB006 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: July 25, 2008
    Publication date: August 5, 2010
    Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventor: Joelle Thonnard
  • BASB119 polypeptide and polynucleotide from
    Patent number: 7691395
    Abstract: The invention provides BASB119 polypeptides and polynucleotides encoding BASB119 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Grant
    Filed: June 14, 2007
    Date of Patent: April 6, 2010
    Assignee: GlaxoSmithKline Biologicals S.A.
    Inventor: Joelle Thonnard
  • MORAXELLA CATARRHALIS BASB115 POLYPEPTIDES
    Publication number: 20100075378
    Abstract: The invention provides BASB115 polypeptides and polynucleotides encoding BASB115 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: November 18, 2009
    Publication date: March 25, 2010
    Applicant: GLAXOSMITHKLINE BIOLOGICALS S.A.
    Inventor: Joelle Thonnard
  • BASB115 polypeptides
    Patent number: 7632516
    Abstract: The invention provides BASB115 polypeptides and polynucleotides encoding BASB115 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Grant
    Filed: July 27, 2000
    Date of Patent: December 15, 2009
    Assignee: GlaxoSmithKline Biologicals S.A.
    Inventor: Joelle Thonnard
  • Haemophilus Influenza Outer Membrane Protein and Use Thereof in Vaccination
    Publication number: 20090175912
    Abstract: This invention relates to recombinant bacterial outer membrane proteins comprising one or more LB1(f) peptides from surface-exposed loop 3 of MOMP P5 of non-typeable H. influenzae. Polynucleotides encoding these recombinant proteins are also covered. The invention also relates to a method of isolating the recombinant proteins and a vaccine composition for use in the treatment of Haemophilus influenzae infection.
    Type: Application
    Filed: December 20, 2007
    Publication date: July 9, 2009
    Inventors: Lauren O. Bakaletz, Francois-Xavier Jacques BERTHET, Philippe Denoel, Jan Poolman, Joelle Thonnard
  • Vaccine Composition
    Publication number: 20090155887
    Abstract: The present invention provides a hyperblebbing non-typeable Haemophilus influenzae bacterium which has been genetically modified by either or both processes selected from a group consisting of: down-regulation of expression of one or more tol genes; and mutation of one or more gene(s) encoding a protein comprising a peptidoglycan-associated site to attenuate the peptidoglycan-binding activity of the protein.
    Type: Application
    Filed: October 22, 2008
    Publication date: June 18, 2009
    Inventors: Francois-Xavier Jacques BERTHET, Philippe Denoel, Cecile Anne Neyt, Jan Poolman, Joelle Thonnard
  • VACCINES COMPRISING OUTER MEMBRANE VESICLES FROM GRAM NEGATIVE BACTERIA
    Publication number: 20090117147
    Abstract: The present invention relates to the field of vaccine formulation, particularly the field of novel adjuvant compositions comprising outer membrane vesicles (or blebs), and advantageous methods of detoxifying these compositions, and advantageous methods of use of such adjuvants.
    Type: Application
    Filed: December 3, 2007
    Publication date: May 7, 2009
    Inventors: Francois-Xavier Jacques BERTHET, Wilfried L J. Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Nathalie Garcon, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet
  • BASB119 Polypeptide and Polynucleotide from Moraxella Catarrhalis
    Publication number: 20080254034
    Abstract: The invention provides BASB119 polypeptides and polynucleotides encoding BASB119 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: June 14, 2007
    Publication date: October 16, 2008
    Applicant: GlaxoSmithKline Biologicals S.A
    Inventor: Joelle Thonnard
  • Polypeptide from haemophilus influenzae
    Publication number: 20080233123
    Abstract: The invention provides BASB203 polypeptides and polynucleotides encoding BASB203 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Application
    Filed: August 6, 2007
    Publication date: September 25, 2008
    Inventor: Joelle Thonnard
  • Vaccine Composition
    Publication number: 20080233154
    Abstract: The present invention relates to an immuno-protective and non-toxic Gram-negative bleb vaccine suitable for paediatric use. Examples of the Gram-negative strains from which the blebs are made are N. meningitidis, M. catarrhalis and H. influenzae. The blebs of the invention are improved by one or more genetic changes to the chromosome of the bacterium, including up-regulation of protective antigens, down-regulation of immunodominant non-protective antigens, and detoxification of the Lipid A moiety of LPS.
    Type: Application
    Filed: August 25, 2006
    Publication date: September 25, 2008
    Inventors: Francois-Xavier Jacques Berthet, Wilfried Dalemans, Philippe Denoel, Guy Dequesne, Christiane Feron, Yves Lobet, Jan Poolman, Georges Thiry, Joelle Thonnard, Pierre Voet
  • Haemophilus influenzae BASB206 gene and protein
    Publication number: 20080226637
    Abstract: This invention relates to polynucleotides, (herein referred to as “BASB206 polynucleotide(s)”), polypeptides encoded by them (referred to herein as “BASB206” or “BASB206 polypeptide(s)”), recombinant materials and methods for their production. In another aspect, the invention relates to methods for using such polypeptides and polynucleotides, including vaccines against bacterial infections. In a further aspect, the invention relates to diagnostic assays for detecting infection of certain pathogens.
    Type: Application
    Filed: November 8, 2005
    Publication date: September 18, 2008
    Applicant: GlaxoSmithKline Biologicals, S.A.
    Inventor: Joelle Thonnard
  • BASB006 polypeptides from and immunogenic compositions thereof
    Patent number: 7419824
    Abstract: The invention provides BASB006 polypeptides and polynucleotides encoding BASB006 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: September 2, 2008
    Assignee: GlaxoSmithKline Biologicals, S.A,.
    Inventor: Joelle Thonnard
  • Polypeptide from haemophilus influenza
    Patent number: 7291722
    Abstract: The invention provides BASB203 polypeptides and polynucleotides encoding BASB203 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are diagnostic, prophylactic and therapeutic uses.
    Type: Grant
    Filed: October 5, 2001
    Date of Patent: November 6, 2007
    Assignee: GlaxoSmithKline Biologicals, S.A.
    Inventor: Joelle Thonnard
  • Haemophilus influenza outer membrane protein and use thereof in vaccination
    Publication number: 20060251671
    Abstract: This invention relates to recombinant bacterial outer membrane proteins comprising one or more LB1(f) peptides from surface-exposed loop 3 of MOMP P5 of non-typeable H. influenzae. Polynucleotides encoding these recombinant proteins are also covered. The invention also relates to a method of isolating the recombinant proteins and a vaccine composition for use in the treatment of Haemophilus influenzae infection.
    Type: Application
    Filed: January 20, 2006
    Publication date: November 9, 2006
    Inventors: Francois-Xavier Berthet, Philippe Denoel, Jan Poolman, Joelle Thonnard