Patents by Inventor Joerg Benz
Joerg Benz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240101657Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.Type: ApplicationFiled: November 15, 2023Publication date: March 28, 2024Applicant: Hoffmann-La Roche Inc.Inventors: ROLAND BECKMANN, JOERG BENZ, STEFAN DENGL, CHRISTIAN GASSNER, GUIDO HARTMANN, PETER MICHAEL HUELSMANN, SABINE IMHOF-JUNG, KRISTIAN HOBOLT JENSEN, HUBERT KETTENBERGER, STEFAN LORENZ, JOERG MOELLEKEN, OLAF MUNDIGL
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Patent number: 11866490Abstract: The present invention relates to anti-VEGF/anti-IL-1beta antibodies and methods of using the same.Type: GrantFiled: September 8, 2021Date of Patent: January 9, 2024Assignee: Hoffmann-La Roche Inc.Inventors: Roland Beckmann, Joerg Benz, Stefan Dengl, Christian Gassner, Guido Hartmann, Peter Michael Huelsmann, Sabine Imhof-Jung, Kristian Hobolt Jensen, Hubert Kettenberger, Stefan Lorenz, Joerg Moelleken, Olaf Mundigl
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Patent number: 11814375Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, B, L1, X, m, n, and R1 to R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: GrantFiled: September 10, 2020Date of Patent: November 14, 2023Assignee: Hoffmann-La Roche Inc.Inventors: Joerg Benz, Luca Gobbi, Uwe Grether, Katrin Groebke Zbinden, Benoit Hornsperger, Carsten Kroll, Bernd Kuhn, Rainer E. Martin, Fionn O'Hara, Bernd Puellmann, Hans Richter, Martin Ritter
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Patent number: 11802133Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: GrantFiled: May 20, 2022Date of Patent: October 31, 2023Assignee: Hoffmann-La Roche Inc.Inventors: Charles Bell, Joerg Benz, Luca Gobbi, Uwe Grether, Katrin Groebke Zbinden, Benoit Hornsperger, Buelent Kocer, Carsten Kroll, Bernd Kuhn, Marius Daniel Rinaldo Lutz, Fionn O'Hara, Hans Richter, Martin Ritter, Didier Rombach, Martin Kuratli
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Publication number: 20230203056Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein X, Y, Z, A, L, B, and R1 to R3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: February 22, 2023Publication date: June 29, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O'HARA, Hans RICHTER, Martin RITTER, Philipp SCHMID
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Publication number: 20230183224Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1, R2 and R3 are as described herein, pharmaceutically acceptable salts thereof, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: November 22, 2022Publication date: June 15, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Charles BELL, Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Buelent KOCER, Bernd KUHN, Hans RICHTER, Satoshi TSUCHIYA
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Publication number: 20230183349Abstract: The present invention relates to anti-PD1 antibodies and methods of using the same.Type: ApplicationFiled: March 3, 2023Publication date: June 15, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Joerg BENZ, Laura CODARRI DEAK, Stefan DENGL, Sebastian FENN, Jens FISCHER, Guy GEORGES, Christian KLEIN, Viktor LEVITSKI, Valeria LIFKE, Oliver PLOETTNER, Stefan SEEBER, Barbara WEISER, Ildiko WUENSCHE, Adrian ZWICK
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Publication number: 20230143310Abstract: The present invention relates to anti-PD1 antibodies and methods of using the same.Type: ApplicationFiled: June 30, 2022Publication date: May 11, 2023Applicant: Hoffmann-La Roche Inc.Inventors: JOERG BENZ, LAURA CODARRI DEAK, STEFAN DENGL, SEBASTIAN FENN, JENS FISCHER, GUY GEORGES, CHRISTIAN KLEIN, VIKTOR LEVITSKI, VALERIA LIFKE, OLIVER PLOETTNER, STEFAN SEEBER, BARBARA WEISER, ILDIKO WUENSCHE, ADRIAN ZWICK
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Publication number: 20230117324Abstract: The invention provides new heterocyclic compounds having the general formula (Ic) wherein A, L, X, m, n and R20 to R23 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: August 9, 2022Publication date: April 20, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Charles BELL, Joerg BENZ, Luca GOBBI, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Dennis Jul HANSEN, Benoit HORNSPERGER, Buelent KOCER, Carsten KROLL, Bernd KUHN, Fionn O'HARA, Hans RICHTER, Martin RITTER, Satoshi TSUCHIYA, Rui CHEN
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Patent number: 11608347Abstract: The invention provides new heterocyclic compounds having the general formula (Ie) wherein R1, R1a and R7 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: GrantFiled: July 7, 2020Date of Patent: March 21, 2023Assignee: Hoffmann-La Roche Inc.Inventors: Ann Petersen, Joerg Benz, Uwe Grether, Benoit Hornsperger, Buelent Kocer, Bernd Kuhn, Hans Richter, Satoshi Tsuchiya, Yangcheng Qiu, Rui Chen
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Publication number: 20230050901Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, X, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: May 20, 2022Publication date: February 16, 2023Applicant: Hoffmann-La Roche Inc.Inventors: Charles BELL, Joerg BENZ, Luca GOBBI, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Buelent KOCER, Carsten KROLL, Bernd KUHN, Marius Daniel Rinaldo LUTZ, Fionn O'HARA, Hans RICHTER, Martin RITTER, Didier ROMBACH, Martin KURATLI
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Publication number: 20220411534Abstract: The present invention generally relates to antibodies that bind to HLA-A2/WT1, including bispecific antigen binding molecules e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.Type: ApplicationFiled: November 4, 2021Publication date: December 29, 2022Applicant: Hoffmann-La Roche Inc.Inventors: Joerg Benz, Christian Klein, Stefan Klostermann, Ekkehard Moessner, Johannes Sam, Pablo UmaƱa, Lydia Jasmin Hanisch, Alexander Bujotzek, Wei Xu
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Publication number: 20220325265Abstract: The present invention provides variants of human ?-Glucocerebrosidase protein.Type: ApplicationFiled: September 7, 2020Publication date: October 13, 2022Applicant: Hoffmann-La Roche Inc.Inventors: Joerg BENZ, Martin EBELING, Ravi JAGASIA, Nina Marion PFAHLER, Ralf THOMA
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Publication number: 20220267349Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein A, L, Q, U, V, W, X, Z, m, n, and R1 to R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: January 31, 2022Publication date: August 25, 2022Applicant: Hoffmann-La Roche Inc.Inventors: Joerg BENZ, Luca GOBBI, Uwe GRETHER, Steven Paul HANLON, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Martin KURATLI, Guofu LIU, Fionn O`HARA, Hans RICHTER, Martin RITTER
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Patent number: 11420961Abstract: The invention provides new heterocyclic compounds having the general formula (IA) wherein A, L, X, Y, m, n, R1 and R2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: GrantFiled: May 27, 2020Date of Patent: August 23, 2022Assignee: Hoffmann-La Roche Inc.Inventors: Joerg Benz, Uwe Grether, Benoit Hornsperger, Buelent Kocer, Bernd Kuhn, Hans Richter, Satoshi Tsuchiya, Charles Bell, Xiang Wu, Xiaofei Yan, Luca Gobbi
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Patent number: 11390610Abstract: The invention provides new heterocyclic compounds having the general Formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, X, Y1 and Y2 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: GrantFiled: March 23, 2020Date of Patent: July 19, 2022Assignee: Hoffmann-La Roche Inc.Inventors: Joerg Benz, Uwe Grether, Benoit Hornsperger, Bernd Kuhn, Hans Richter, Buelent Kocer, Fionn O'Hara, Martin Ritter, Satoshi Tsuchiya, Ludovic Collin, Simon E. Johnson, Charles Bell
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Publication number: 20220220373Abstract: The invention provides fluorescent probes having the general formula (I) wherein X, Y, L and R1 to R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: March 22, 2022Publication date: July 14, 2022Applicant: Hoffmann-La Roche Inc.Inventors: Joerg BENZ, Thais GAZZI, Luca GOBBI, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Yelena MOSTINSKI, Marc NAZARE, Fionn O'HARA, Hans RICHTER
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Publication number: 20220213093Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein R1 to R3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: December 16, 2021Publication date: July 7, 2022Applicant: Hoffmann-La Roche Inc.Inventors: Joerg BENZ, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Fionn O'HARA, Hans RICHTER
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Publication number: 20220135591Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein R1 to R7, A, L1, and RA1 to RA3 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: October 8, 2021Publication date: May 5, 2022Applicant: Hoffmann-La Roche Inc.Inventors: Joerg BENZ, Guillaume DECORET, Uwe GRETHER, Katrin GROEBKE ZBINDEN, Benoit HORNSPERGER, Bernd KUHN, Hans RICHTER, Didier ROMBACH, Fionn O'HARA, Carsten KROLL
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Publication number: 20220106328Abstract: The invention provides new heterocyclic compounds having the general formulae (Ia) and (Ib) wherein A, B, and L are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.Type: ApplicationFiled: December 16, 2021Publication date: April 7, 2022Applicant: Hoffmann-La Roche Inc.Inventors: Joerg BENZ, Luca GOBBI, Uwe GRETHER, Benoit HORNSPERGER, Carsten KROLL, Bernd KUHN, Rainer E. MARTIN, Fionn O`HARA, Bernd PUELLMANN, Hans RICHTER, Martin RITTER