Patents by Inventor Joerg Brockob

Joerg Brockob has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate active compound product having improved properties, production and formulation thereof
    Patent number: 12172996
    Abstract: The present invention relates to methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate in the form of a novel active compound product having improved properties, for example in respect of the isolability of the active compound product, the dischargeability of the active compound product after isolation and drying and also conveyability, sieveability and micronizability of the active compound product, and to processes for the production and formulation thereof.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: December 24, 2024
    Assignee: Adverio Pharma GmbH
    Inventors: Peter Fey, Michal Sowa, Joerg Brockob, Markus Longerich, Guido Becker, Heike Neumann
  • PROCESS FOR PREPARING METHYL {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3 -YL]PYRIMIDIN-5-YL} CARBAMATE
    Publication number: 20230219952
    Abstract: The present application relates to a novel and efficient process with high yield for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate of the formula (I) in the crystalline form of modification I, wherein the x-ray diffractogram of the compound of the formula (I) in modification exhibits peak maxima of the 2 theta angle at 5.9, 6.9, 22.7, in very high purity which is significantly more cost-effective than the process known from the art and can be performed in customary pilot- and production plant-equipment (stirred tank/devices for isolation).
    Type: Application
    Filed: June 15, 2021
    Publication date: July 13, 2023
    Inventors: Peter FEY, Nadine BREMEYER, Markus LONGERICH, Thomas FRENZEL, Helene FABER, Michal SOWA, Joerg BROCKOB, Guido BECKER, Heike NEUMANN
  • NANOFORMULATIONS OF METHYL {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3 -YL]PYRIMIDIN-5-YL} CARBAMATE
    Publication number: 20230067593
    Abstract: The present invention relates to stable nanosuspensions of methyl {4,6-diamino-2-[5-fluoro-1-(2- fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate (Vericiguat, compound of formula (I)), processes for preparing the stable nanosuspensions, nanoparticles comprising the compound of formula (I), and pharmaceutical compositions in solid form made from the nanosuspensions.
    Type: Application
    Filed: February 2, 2021
    Publication date: March 2, 2023
    Inventors: Elisabeth KERSTEN, Michael OSTENDORF, Werner HOHEISEL, Heike NEUMANN, Michal SOWA, Joerg BROCKOB, Peter FEY, Markus LONGERICH, Guido BECKER, Valentina Paula CONTY, Anja EHRIG
  • METHYL {4,6-DIAMINO-2-[5-FLUORO-1-(2-FLUOROBENZYL)-1H-PYRAZOLO[3,4-B]PYRIDIN-3-YL]PYRIMIDIN-5-YL}CARBAMATE ACTIVE COMPOUND PRODUCT HAVING IMPROVED PROPERTIES, PRODUCTION AND FORMULATION THEREOF
    Publication number: 20220048907
    Abstract: The present invention relates to methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate in the form of a novel active compound product having improved properties, for example in respect of the isolability of the active compound product, the dischargeability of the active compound product after isolation and drying and also conveyability, sieveability and micronizability of the active compound product, and to processes for the production and formulation thereof.
    Type: Application
    Filed: December 16, 2019
    Publication date: February 17, 2022
    Applicant: Adverio Pharma GmbH
    Inventors: Peter Fey, Michal Sowa, Joerg Brockob, Markus Longerich, Guido Becker, Heike Neumann