Abstract: The invention generally relates to the field of individualized medicine. It is a kind of liquid biopsy for individualizing and monitoring treatment in patients with tumors and for diagnosis of tumors. The invention relates to a method for identifying and characterizing subpopulations (subgroups) of circulating tumor cells (CTCs) in a population of CTCs in a biological sample, preferably in a blood sample of the patient. The invention also relates to the quantification of the respective subgroups of CTCs in the population of CTCs in the biological sample. The invention further relates to the use of the method for diagnosis and monitoring of tumors, decisions relating to treatment, surveillance of treatment and prognosis, in particular for all kinds of solid tumors. The invention further relates to the use of the identified CTC subgroups as biomarkers for diagnosis, prognosis and therapeutic treatment.

Abstract: The invention generally relates to the field of individualized medicine. It is a kind of liquid biopsy for individualizing and monitoring treatment in patients with tumors and for diagnosis of tumors. The invention relates to a method for identifying and characterizing subpopulations (subgroups) of circulating tumor cells (CTCs) in a population of CTCs in a biological sample, preferably in a blood sample of the patient. The invention also relates to the quantification of the respective subgroups of CTCs in the population of CTCs in the biological sample. The invention further relates to the use of the method for diagnosis and monitoring of tumors, decisions relating to treatment, surveillance of treatment and prognosis, in particular for all kinds of solid tumors. The invention further relates to the use of the identified CTC subgroups as biomarkers for diagnosis, prognosis and therapeutic treatment.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device in a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device in a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device in a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: The invention relates to a process for producing a titanium dioxide pigment obtainable by the sulfate process with a narrow particle size distribution, the pigment itself, and the use of said pigments in coatings and printing inks.

Abstract: A method for coating the surface of inorganic solid particles in an aqueous suspension, particularly for coating titanium dioxide with SiO2 includes: a) disagglomeration of the solid particles contained in aqueous suspension, b) addition of a water-soluble precursor of the coating substance to the suspension, c) immediately following step b) homogenization of the suspension, where the temperature and pH value of the suspension do not change significantly in steps a) to c), d) feeding the slurry into a tank and precipitation of the coating substance onto the particle surface and, optionally, application of further coatings, and e) separation of the solid particles from the suspension. The method produces to a highly homogeneous and continuous skin on the particle surface, and to less separately precipitated coating substance.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device in a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: The invention relates to a process for producing a titanium dioxide pigment obtainable by the sulfate process with a narrow particle size distribution, the pigment itself, and the use of said pigments in coatings and printing inks.

Abstract: A method for manufacturing a photocatalyst, based on titanium dioxide containing carbon or metal, in a pulsation reactor, where a raw material mixture, consisting of nanoparticulate titanium oxyhydrate and an aqueous solution or suspension, containing at least one organic, carbon-containing compound or metal ions, is fed into the pulsating hot-gas stream of the pulsation reactor and the titanium dioxide particles containing carbon or metal are formed. The hot-gas stream has a temperature of ?450° C. following addition of the material and contains an excess of oxygen. In contrast to the known manufacturing methods, the method according to the invention allows reproducibly good product qualities to be achieved.

Abstract: A method for manufacturing a photocatalyst, based on titanium dioxide containing carbon or metal, in a pulsation reactor, where a raw material mixture, consisting of nanoparticulate titanium oxyhydrate and an aqueous solution or suspension, containing at least one organic, carbon-containing compound or metal ions, is fed into the pulsating hot-gas stream of the pulsation reactor and the titanium dioxide particles containing carbon or metal are formed. The hot-gas stream has a temperature of ?450° C. following addition of the material and contains an excess of oxygen. In contrast to the known manufacturing methods, the method according to the invention allows reproducibly good product qualities to be achieved.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device. In a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device in a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: The invention relates to specific marker proteins (biomarkers) for Hepatocellular carcinoma (HCC). The invention relates to a method for the diagnostic study of biological samples of a human for Hepatocellular carcinoma, the sample being studied for one or more proteins as a marker for Hepatocellular carcinoma, a concentration of the proteins which is elevated or decreased in relation to the healthy state indicating the presence of Hepatocellular carcinoma, a diagnostic test kit and a method of screening compounds effective in HCC.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device in a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: This invention relates to the treatment of hepatitis infections or hepatitis diseases, in particular hepatitis C. The invention more particularly relates to the use of an inhibitor and/or repressor of a nucleic acid molecule, especially gene, which is related to the proliferation and/or replication of hepatitis viruses, in particular hepatitis C viruses, in order to produce a medicament for preventing and/or curing hepatitis, in particular hepatitis C, as well as a pharmaceutical composition, preferably for preventing or treating hepatitis C diseases, said composition containing the repressor and/or inhibitor.

Abstract: A method for coating the surface of inorganic solid particles in an aqueous suspension, particularly for coating titanium dioxide with SiO2 includes: a) disagglomeration of the solid particles contained in aqueous suspension, b) addition of a water-soluble precursor of the coating substance to the suspension, c) immediately following step b) homogenization of the suspension, where the temperature and pH value of the suspension do not change significantly in steps a) to c), d) feeding the slurry into a tank and precipitation of the coating substance onto the particle surface and, optionally, application of further coatings, and e) separation of the solid particles from the suspension. The method produces to a highly homogeneous and continuous skin on the particle surface, and to less separately precipitated coating substance.

Abstract: A method for reprocessing cyclone dust occurring during the carbochlorination of titaniferous raw materials, which essentially consists of titanium dioxide, coke and other inert metal oxides, such as silicon dioxide, and for returning a coke-rich and/or a TiO2-rich fraction to the chlorination reactor includes: preparing an aqueous suspension of the cyclone dust; separating a coke-rich fraction (1) from the aqueous suspension by flotation; adding hydrofluoric acid to the remaining suspension; and separating a TiO2-rich fraction (2) by flotation from the remaining suspension.

Abstract: A chuck is described, in particular for a hammer drill or chisel hammer, having a chuck body having an insertion opening for holding a tool shank, and a locking element for axially locking the tool shank in the insertion opening, the locking element being movable between a locked position and an unlocked position, and having an arresting pin, mounted in the locking element and radially displaceable between an arresting position and a release position, which axially arrests the locking element in its arresting position and axially releases it in its release position.

Abstract: A gas generator has a propellant charge and an early ignition device held loosely in the propellant charge. The early ignition device consists of an early ignition charge and an enclosure surrounding the early ignition charge. The enclosure is at least one foil wrapped around the early ignition charge. The outer edges of the foil, lying one over another, are connected with each other to close the enclosure.