Abstract: The invention generally relates to the field of individualized medicine. It is a kind of liquid biopsy for individualizing and monitoring treatment in patients with tumors and for diagnosis of tumors. The invention relates to a method for identifying and characterizing subpopulations (subgroups) of circulating tumor cells (CTCs) in a population of CTCs in a biological sample, preferably in a blood sample of the patient. The invention also relates to the quantification of the respective subgroups of CTCs in the population of CTCs in the biological sample. The invention further relates to the use of the method for diagnosis and monitoring of tumors, decisions relating to treatment, surveillance of treatment and prognosis, in particular for all kinds of solid tumors. The invention further relates to the use of the identified CTC subgroups as biomarkers for diagnosis, prognosis and therapeutic treatment.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device in a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device in a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device in a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: The invention relates to a process for producing a titanium dioxide pigment obtainable by the sulfate process with a narrow particle size distribution, the pigment itself, and the use of said pigments in coatings and printing inks.

Abstract: A method for coating the surface of inorganic solid particles in an aqueous suspension, particularly for coating titanium dioxide with SiO2 includes: a) disagglomeration of the solid particles contained in aqueous suspension, b) addition of a water-soluble precursor of the coating substance to the suspension, c) immediately following step b) homogenization of the suspension, where the temperature and pH value of the suspension do not change significantly in steps a) to c), d) feeding the slurry into a tank and precipitation of the coating substance onto the particle surface and, optionally, application of further coatings, and e) separation of the solid particles from the suspension. The method produces to a highly homogeneous and continuous skin on the particle surface, and to less separately precipitated coating substance.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device in a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: The invention relates to a process for producing a titanium dioxide pigment obtainable by the sulfate process with a narrow particle size distribution, the pigment itself, and the use of said pigments in coatings and printing inks.

Abstract: The invention relates to a method for coating the surface of inorganic solid particles in an aqueous suspension. The untreated particles, particularly TiO2 base material, are made into an aqueous suspension and subsequently disagglomerated. According to the invention, a disagglomerated suspension of untreated particles is fed (recirculated) from an intermediate vessel (vessel) in a cyclic process. The intermediate vessel contains a high-speed agitator preferably having a minimum peripheral speed of 15 m/s or a specific agitator capacity P/V of at least 30 W/m3. A pipeline mixer (e.g. inline disperser) based on the rotor/stator principle is furthermore installed in the circuit. The water-soluble precursor compounds of the coating substances, and equally any necessary pH-controlling substances, are metered into the pipeline mixer.

Abstract: A method for manufacturing a photocatalyst, based on titanium dioxide containing carbon or metal, in a pulsation reactor, where a raw material mixture, consisting of nanoparticulate titanium oxyhydrate and an aqueous solution or suspension, containing at least one organic, carbon-containing compound or metal ions, is fed into the pulsating hot-gas stream of the pulsation reactor and the titanium dioxide particles containing carbon or metal are formed. The hot-gas stream has a temperature of ?450° C. following addition of the material and contains an excess of oxygen. In contrast to the known manufacturing methods, the method according to the invention allows reproducibly good product qualities to be achieved.

Abstract: The invention generally relates to the field of individualized medicine. It is a kind of liquid biopsy for individualizing and monitoring treatment in patients with tumors and for diagnosis of tumors. The invention relates to a method for identifying and characterizing subpopulations (subgroups) of circulating tumor cells (CTCs) in a population of CTCs in a biological sample, preferably in a blood sample of the patient. The invention also relates to the quantification of the respective subgroups of CTCs in the population of CTCs in the biological sample. The invention further relates to the use of the method for diagnosis and monitoring of tumors, decisions relating to treatment, surveillance of treatment and prognosis, in particular for all kinds of solid tumors. The invention further relates to the use of the identified CTC subgroups as biomarkers for diagnosis, prognosis and therapeutic treatment.

Abstract: A method for manufacturing a photocatalyst, based on titanium dioxide containing carbon or metal, in a pulsation reactor, where a raw material mixture, consisting of nanoparticulate titanium oxyhydrate and an aqueous solution or suspension, containing at least one organic, carbon-containing compound or metal ions, is fed into the pulsating hot-gas stream of the pulsation reactor and the titanium dioxide particles containing carbon or metal are formed. The hot-gas stream has a temperature of ?450° C. following addition of the material and contains an excess of oxygen. In contrast to the known manufacturing methods, the method according to the invention allows reproducibly good product qualities to be achieved.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device. In a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: An inflator as well as a method of manufacturing an inflator, a module including an inflator and an airbag module. In an inflator, especially for a protective device in a vehicle, comprising plural components a sealant is applied in the area of abutting components, especially a sealant which adheres to both abutting components.

Abstract: The invention relates to a method for coating the surface of inorganic solid particles in an aqueous suspension. The untreated particles, particularly TiO2 base material, are made into an aqueous suspension and subsequently disagglomerated. According to the invention, a disagglomerated suspension of untreated particles is fed (recirculated) from an intermediate vessel (vessel) in a cyclic process. The intermediate vessel contains a high-speed agitator preferably having a minimum peripheral speed of 15 m/s or a specific agitator capacity P/V of at least 30 W/m3. A pipeline mixer (e.g. inline disperser) based on the rotor/stator principle is furthermore installed in the circuit. The water-soluble precursor compounds of the coating substances, and equally any necessary pH-controlling substances, are metered into the pipeline mixer.

Abstract: The invention relates to specific marker proteins (biomarkers) for Hepatocellular carcinoma (HCC). The invention relates to a method for the diagnostic study of biological samples of a human for Hepatocellular carcinoma, the sample being studied for one or more proteins as a marker for Hepatocellular carcinoma, a concentration of the proteins which is elevated or decreased in relation to the healthy state indicating the presence of Hepatocellular carcinoma, a diagnostic test kit and a method of screening compounds effective in HCC.

Abstract: Provided is a process for making non-phthalate plasticizers, by acylating an aromatic compound with a succinic anhydride to form a keto-acid, and then esterifying the keto-acid with C4-C13 OXO-alcohols to form a plasticizer compound. The aromatic rings of the aromatic compound may also be optionally hydrogenated.

Abstract: Provided are compounds of the formula: wherein m=0-3 and n=0-3, and R1 represents CxH2x wherein x=0 to 4 or cyclohexane; R2 represents H, a C1-C6 alkyl group at any of the ortho-, meta- or para-positions, a residue including heteroatoms chosen from O, N, and S, or mixtures thereof; and R3 and R4 represent hydrocarbon residues of OXO-C5-C9 alcohols which are different isomers of equal carbon number or different in carbon number. Also provided are processes for making the compounds and plasticized polymer compositions containing said compounds.

Abstract: Provided are compounds of the formula: wherein m=0-3 and n=0-3, and R1 represents CxH2x wherein x=0 to 4 or cyclohexane; R2 represents H, a C1-C6 alkyl group at any of the ortho-, meta- or para-positions, a residue including heteroatoms chosen from O, N, and S, or mixtures thereof; and R3 and R4 represent hydrocarbon residues of OXO-C5-C9 alcohols which are different isomers of equal carbon number or different in carbon number. Also provided are processes for making the compounds and plasticized polymer compositions containing said compounds.

Abstract: A process for making non-phthalate, 1,2-phenylene oxo-diester plasticizers for polymer compositions, by selectively hydrogenating naphthalene to form a partially hydrogenated naphthalene, oxygenating said partially hydrogenated naphthalene to form phenylene diacids, and esterifying said phenylene diacids with oxo-alcohols to form 1,2-phenylene oxo-diesters. Also a process for making phenylene oxo-diester plasticizers by selectively brominating xylenes to form bisbromomethylbenzene, catalytic carboalkoxylation of the bromo-compound to form phenylene diacetate, followed by transesterification to form the phenylene oxo-diester.