Abstract: Disclosed is a method of providing control data for an additive manufacturing device. The method includes accessing computer-based model data of at least a portion of the object to be manufactured, generating at least one data model of a region of a building material layer to be selectively solidified for manufacturing the at least one object portion. The data model specifies solidification of the building material, and the end point of the at least one solidification path a set of energy introduction parameter values is specified which generates a reference value for the radiation power per unit area in the radiation impact area of the beam bundle on the building material which is lower than the reference value for the radiation power per unit area at other locations of the solidification path, and providing control data corresponding to the generated at least one data model for generating a control data set for the additive manufacturing device.

Abstract: Disclosed is a method of providing control data for an additive manufacturing device. The method includes accessing computer-based model data of at least a portion of the object to be manufactured, generating at least one data model of a region of a building material layer to be selectively solidified for manufacturing the at least one object portion. The data model specifies solidification of the building material, and the end point of the at least one solidification path a set of energy introduction parameter values is specified which generates a reference value for the radiation power per unit area in the radiation impact area of the beam bundle on the building material which is lower than the reference value for the radiation power per unit area at other locations of the solidification path, and providing control data corresponding to the generated at least one data model for generating a control data set for the additive manufacturing device.

Abstract: A device is disclosed for producing a three-dimensional object by layerwise construction. The device contains a flow device for generating a gas flow above an applied layer of the building material by means of a nozzle element for introducing the gas into the device. The nozzle element includes a body with a gas inlet side and a gas outlet side, and channels which penetrate the body from the gas inlet side to the gas outlet side, provided with inlet openings on the gas inlet side and gas outlet openings on the gas outlet side, and which are separated by walls. The length of the channels is selected such that a laminar flow is formed at the gas outlet side.

Abstract: A device (1), for producing a three-dimensional object (2) by solidifying, layer-by-layer, building material (13) at locations in the respective layer corresponding to the cross-section of the object (2) to be produced, contains a flow device (31, 32, 34, 35) for generating a gas flow above an applied layer of the building material (13) by means of a nozzle element (40) for introducing the gas into the device. The nozzle element (40) comprises a body (41) with a gas inlet side and a gas outlet side (46), and a plurality of channels (42) which penetrate the body from the gas inlet side (44) to the gas outlet side (46), are provided with inlet openings on the gas inlet side (44) and with gas outlet openings (47) on the gas outlet side (46), and which are separated by walls (43). The length of the channels (42) is selected such that therein a laminar flow is formed at the gas outlet side (46).

Abstract: The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine.

Abstract: The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine.

Abstract: The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine.

Abstract: The present patent application relates to an alternative process for the preparation of amino derivatives. In particular, the present application relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide, which is useful as an anticonvulsive drug. In a particular aspect, the present invention relates to a process of manufacture of optically enriched (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (I) comprising resolution of 2-acetamido-N-benzyl-3-methoxypropion-amide (II).

Abstract: The present invention provides a process for the preparation of lacosamide in substantially optically pure form, which in one aspect comprises the following steps: (i) resolution of O-methyl-D,L-serine to provide O-methyl-D-serine in substantially optically pure form; (ii) acetylation of O-methyl-D-serine thereby obtained to provide the N-acetyl 10 derivative thereof in substantially optically pure form; (iii) activating the carboxy group of the compound thereby obtained; and (iv) reacting the compound thereby obtained with benzylamine.

Abstract: The present patent application relates to an alternative process for the preparation of amino derivatives. In particular, the present application relates to an improved process for the manufacture of Lacosamide (LCM), (R)-2-acetamido-N-benzyl-3-methoxypropion-amide, which is useful as an anticonvulsive drug. In a particular aspect, the present invention relates to a process of manufacture of optically enriched (R)-2-acetamido-N-benzyl-3-methoxypropion-amide (I) comprising resolution of 2-acetamido-N-benzyl-3-methoxypropion-amide (II).

Abstract: A method for regulating immunological interaction comprising inhibiting the binding between cells bearing CD55 protein and activated leucocytes bearing CD97 protein.