Abstract: The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

Abstract: The present application relates to novel substituted piperidinylpyrazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired hemostatic disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of heavy menstrual bleeding, postpartum hemorrhage, hemorrhagic shock, hemorrhagic cystitis, gastrointestinal hemorrhage, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.

Abstract: In an exhaust gas turbocharger system for charging an engine including a compressor arrangement at a charging fluid side LL and a turbine arrangement at an exhaust gas side AG, a further compressor which is driven by a separate controllable drive and whose primary side is connected to the charging fluid side LL while its secondary side is connected to the exhaust gas side is provided for compressing charge air taken from the charging fluid side and supply it to the exhaust gas side for assisting driving the exhaust gas turbines so as to maintain them at relatively high speeds in transition periods including engine idling.

Abstract: In an exhaust gas turbocharger system for charging an engine including a compressor arrangement at a charging fluid side LL and a turbine arrangement at an exhaust gas side AG, a further compressor which is driven by a separate controllable drive and whose primary side is connected to the charging fluid side LL while its secondary side is connected to the exhaust gas side is provided for compressing charge air taken from the charging fluid side and supply it to the exhaust gas side for assisting driving the exhaust gas turbines so as to maintain them at relatively high speeds in transition periods including engine idling.