Abstract: Aspects of the disclosure relate to mobile-optimized software tools that may be deployed and used to measure spatial working memory across diverse clinical trial populations. For example, some aspects describe computational optimization and participatory design of a novel spatial working memory task for clinical trials relating to autism spectrum disorders (ASD) or other neurological conditions (e.g., Alzheimer's disease). Software tools as described herein may be used for measuring treatment effects on spatial working memory and/or provide treatments to improve a patient's spatial working memory. Digital biomarkers may be generated for each patient based on the patient's spatial working memory.

Abstract: The present disclosure relates to the field of schizophrenia or an autism spectrum disorder (“ASD”) diagnostics and disease management. Specifically, the present disclosure teaches a method of assessing schizophrenia or ASD in a subject in which a subject's usage data for a mobile device is collected over a first predefined time window. A usage behavior parameter is determined from the usage data, and the determined usage behavior parameter is compared to a reference. From the comparison it may be determined whether the schizophrenia or ASD in the subject is improving, persisting or worsening. A system including a mobile device having sensors recording usage data and a remote device operatively linked to the mobile device is also disclosed.