Patents by Inventor Joerg Holenz

Joerg Holenz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol
    Patent number: 11739049
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: August 29, 2023
    Assignee: Grünenthal GmbH
    Inventors: Wolfgang Hell, Oswald Zimmer, Helmut Heinrich Buschmann, Joerg Holenz, Stefan Gladow
  • Heterocyclic Amides as Kinase Inhibitors
    Publication number: 20230192676
    Abstract: Disclosed are compounds having the formula (I) wherein R1, R2, and R3 are as defined herein, and methods of making and using the same.
    Type: Application
    Filed: December 27, 2018
    Publication date: June 22, 2023
    Inventors: Ryan Michael Fox, Philip Anthony Harris, Joerg Holenz, Mark Andrew Seefeld, Ding Zhou
  • PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL
    Publication number: 20210130282
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Application
    Filed: January 6, 2021
    Publication date: May 6, 2021
    Applicant: GRÜNENTHAL GMBH
    Inventors: WOLFGANG HELL, OSWALD ZIMMER, HELMUT HEINRICH BUSCHMANN, JOERG HOLENZ, STEFAN GLADOW
  • PROCESS FOR THE PREPARATION OF (1R,2R)-3-(3-DIMETHYLAMINO-1-ETHYL-2-METHYL-PROPYL)-PHENOL
    Publication number: 20200299225
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Application
    Filed: June 9, 2020
    Publication date: September 24, 2020
    Applicant: GRUNENTHAL GMBH
    Inventors: WOLFGANG HELL, OSWALD ZIMMER, HELMUT HEINRICH BUSCHMANN, JOERG HOLENZ, STEFAN GLADOW
  • Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
    Patent number: 9850198
    Abstract: A process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds which has advantages over conventional processes with respect to higher conversions and yields, flexibility, a shorter overall route, environmentally acceptable conditions, influence of stereoselectivity such as diastereoselectivity in a targeted manner and at least partial suppression of the formation of undesired side-products and/or undesired stereoisomers, in particular undesired diastereomers.
    Type: Grant
    Filed: May 17, 2016
    Date of Patent: December 26, 2017
    Assignee: GRUENENTHAL GMBH
    Inventors: Helmut Heinrich Buschmann, Joerg Holenz
  • Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds
    Publication number: 20160257640
    Abstract: A process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds which has advantages over conventional processes with respect to higher conversions and yields, flexibility, a shorter overall route, environmentally acceptable conditions, influence of stereoselectivity such as diastereoselectivity in a targeted manner and at least partial suppression of the formation of undesired side-products and/or undesired stereoisomers, in particular undesired diastereomers.
    Type: Application
    Filed: May 17, 2016
    Publication date: September 8, 2016
    Inventors: Helmut Heinrich BUSCHMANN, Joerg HOLENZ
  • Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
    Patent number: 9388119
    Abstract: A process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds which has advantages over conventional processes with respect to higher conversions and yields, flexibility, a shorter overall route, environmentally acceptable conditions, influence of stereoselectivity such as diastereoselectivity in a targeted manner and at least partial suppression of the formation of undesired side-products and/or undesired stereoisomers, in particular undesired diastereomers.
    Type: Grant
    Filed: August 21, 2013
    Date of Patent: July 12, 2016
    Assignee: GRUENENTHAL GMBH
    Inventors: Helmut Heinrich Buschmann, Joerg Holenz
  • Process for the preparation of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methylpropy1)-phenol
    Patent number: 8877974
    Abstract: The present invention relates to a process for the preparation of (1R,2R)-3-dimethylamino-1-ethyl-2-methyl-propyl)-phenol.
    Type: Grant
    Filed: July 23, 2007
    Date of Patent: November 4, 2014
    Assignee: Grünenthal GmbH
    Inventors: Wolfgang Hell, Oswald Zimmer, Helmut Heinrich Buschmann, Joerg Holenz, Stefan Gladow
  • Process for preparing substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds
    Patent number: 8669399
    Abstract: A process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds which has advantages over conventional processes with respect to higher conversions and yields, flexibility, a shorter overall route, environmentally acceptable conditions, influence of stereoselectivity such as diastereoselectivity in a targeted manner and at least partial suppression of the formation of undesired side-products and/or undesired stereoisomers, in particular undesired diastereomers.
    Type: Grant
    Filed: June 14, 2011
    Date of Patent: March 11, 2014
    Assignee: Grünenthal GmbH
    Inventors: Helmut Heinrich Buschmann, Joerg Holenz
  • Process for Preparing Substituted 3-(1-amino-2-methylpentane-3-yl)phenyl Compounds
    Publication number: 20130338399
    Abstract: A process for the preparation of substituted 3-(1-amino-2-methylpentane-3-yl)phenyl compounds which has advantages over conventional processes with respect to higher conversions and yields, flexibility, a shorter overall route, environmentally acceptable conditions, influence of stereoselectivity such as diastereoselectivity in a targeted manner and at least partial suppression of the formation of undesired side-products and/or undesired stereoisomers, in particular undesired diastereomers.
    Type: Application
    Filed: August 21, 2013
    Publication date: December 19, 2013
    Applicant: Gruenenthal GmbH
    Inventors: Helmut Heinrich BUSCHMANN, Joerg Holenz
  • 1-Phenyl-2-Dimethylaminomethyl Cyclohexane Compounds And Therapies For Depressive Symptoms, Pain and Incontinence
    Publication number: 20130296414
    Abstract: Metabolites of [2-(3-methoxyphenyl)-cyclohexylmethyl]dimethylamine as free bases and/or in the form of physiologically acceptable salts, corresponding medicaments, the use of [2-(3-methoxyphenyl)-cyclohexylmethyl]-dimethylamine and the metabolites thereof for producing a medicament used for treating depression, and related methods of treating depression, pain and urinary incontinence.
    Type: Application
    Filed: July 3, 2013
    Publication date: November 7, 2013
    Inventors: Elmar FRIDERICHS, Wolfgang STRASSBURGER, Ulrich JAHNEL, Helmut BUSCHMANN, Joerg HOLENZ, Oswald ZIMMER, Derek SAUNDERS, Werner ENGLBERGER, Hagen-Heinrich HENNIES
  • Substituted 1-oxa-2,8-diaza-spiro [4,5] dec-2-ene derivatives and related treatment methods
    Patent number: 8557796
    Abstract: Substituted 1-oxa-2,8-diaza-spiro[4,5]dec-2-ene compounds and processes for their production, the use thereof for producing pharmaceutical compositions, pharmaceutical compositions containing these compounds and methods of treatment using these compounds.
    Type: Grant
    Filed: May 26, 2011
    Date of Patent: October 15, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Heinrich Helmut Buschmann, Guenter Werner Englberger, Tieno Germann, Hagen-Henrich Hennies, Corinna Maul, Bernd Sundermann, Joerg Holenz
  • Sigma receptor compounds
    Patent number: 8481567
    Abstract: The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: March 2, 2007
    Date of Patent: July 9, 2013
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Jordi Corbera-Arjona, David Vano-Domenech, Joerg Holenz
  • Sigma receptor inhibitors
    Patent number: 8470867
    Abstract: The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: June 25, 2013
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Christian Laggner, María Rosa Cuberes-Altisent, Joerg Holenz, Juana María Berrocal-Romero, Maria Montserrat Contijoch-Llobet
  • Imidazole compounds having pharmaceutical activity towards the sigma receptor
    Patent number: 8410159
    Abstract: The present invention relates to compounds of formula (I), methods for their preparation, medicaments comprising these compounds as well their use in the manufacture of a medicament for the treatment of humans and animals.
    Type: Grant
    Filed: July 29, 2011
    Date of Patent: April 2, 2013
    Assignee: Laboratories del Dr. Esteve, S.A.
    Inventors: Rosa Cuberes-Altisent, Joerg Holenz
  • Substituted pyrazole sigma receptor antagonists
    Patent number: 8394797
    Abstract: The invention relates to compounds having pharmacological activity towards the sigma receptor, and more particularly to pyrazole derivatives of formula I and to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use therapy and prophylaxis, in particular for the treatment of psychosis or pain.
    Type: Grant
    Filed: September 29, 2010
    Date of Patent: March 12, 2013
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: Jordi Corbera Arjona, Maria Rosa Cuberes-Altisent, Joerg Holenz, Daniel Martínez-Olmo, David Vaño-Domenech
  • Sigma receptor inhibitors
    Patent number: 8314096
    Abstract: The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: November 20, 2012
    Assignee: Laboratorios del Dr. Esteve, S.A.
    Inventors: Christian Laggner, Maria Rosa Cuberes-Altisent, Joerg Holenz, Juana Maria Berrocal-Romero, Maria Montserrat Contijoch-Llobet
  • Sigma receptor inhibitors
    Patent number: 8293740
    Abstract: The invention relates to compounds of formula (I) having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Grant
    Filed: February 9, 2010
    Date of Patent: October 23, 2012
    Assignee: Laboratories Del Dr. Esteve, S.A.
    Inventors: Christian Laggner, Maria Rosa Cuberes-Altisent, Joerg Holenz, Juana Maria Berrocal-Romero, Maria Montserrat Contijoch-Llobet
  • PYRAZOLE DERIVATIVES AS SIGMA RECEPTOR INHIBITORS
    Publication number: 20120232093
    Abstract: The invention relates to compounds of formula I having pharmacological activity towards the sigma receptor, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use for the treatment and or prophylaxis of a disease in which the sigma receptor is involved.
    Type: Application
    Filed: May 24, 2012
    Publication date: September 13, 2012
    Applicant: LABORATORIOS DEL DR. ESTEVE, S.A.
    Inventors: Rosa CUBERES-ALTISENT, Joerg HOLENZ
  • Tetrahydro-?-carbolin-sulfonamide derivatives as 5-Htligands
    Patent number: 8263609
    Abstract: The present invention relates to new tetrahydro-?-carbolin-sulfonamide derivatives of general formula (I), optionally in form of one of their stereoisomers, preferably enantiomers or diastereomers, their racemates or in form of a mixture of at least two of their stereoisomers, preferably enantiomers or diastereomers, in any mixing ratio, or corresponding physiologically acceptable salts or corresponding solvates. These compounds are suitable as pharmacologically active agents in a medicament for the prophylaxis and/or treatment of disorders or diseases related to 5-HT6 receptors. The invention also relates to two different methods for obtaining the mentioned compounds and to pharmaceutical compositions containing them.
    Type: Grant
    Filed: July 26, 2006
    Date of Patent: September 11, 2012
    Assignee: Laboratorios Del Dr. Esteve, S.A.
    Inventors: José Luis Díaz-Fernández, Ramón Mercé-Vidal, Joerg Holenz