Patents by Inventor Joerg Keldenich

Joerg Keldenich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210386864
    Abstract: The present invention relates to novel pharmaceutical compounds comprising of an ?v?3 integrin antagonist, a linking unit comprising of L-Val-L-Pro-L-Asp cleavable by elastase, a polyethyleneglycol (PEG) spacer and a cytotoxic element, to processes for preparation thereof, to the use thereof for treating, preventing or managing diseases and conditions including hyperproliferative disorders such as cancer in humans and other mammals.
    Type: Application
    Filed: October 30, 2019
    Publication date: December 16, 2021
    Inventors: Hans-Georg LERCHEN, Beatrix STELTE-LUDWIG, Charlotte Christine KOPITZ, Jörg KELDENICH
  • Patent number: 10053428
    Abstract: The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: August 21, 2018
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Michael Hahn, Markus Follmann, Eva-Maria Becker, Johannes-Peter Stasch, Joerg Keldenich, Martina Delbeck, Hanna Tinel, Frank Wunder, Joachim Mittendorf, Ildiko Terebesi, Dieter Lang, René Martin, Walter Hübsch
  • Patent number: 10047096
    Abstract: The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
    Type: Grant
    Filed: November 23, 2015
    Date of Patent: August 14, 2018
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Andreas Schall, Jürgen Klar, Mario Lobell, Hartmut Schirok, Joachim Telser, Steffen Müller, Dirk Brohm, Hans Briem, Hannah Jörißen, Joerg Keldenich, Michael Böttger, Georges Von Degenfeld, Thomas Schlange, Ulf Bömer, Niels Lindner, Hanna Eilken, Dmitrij Hristodorov, Pierre Wasnaire, Kersten Matthias Gericke, Lars Bärfacker
  • Publication number: 20170260139
    Abstract: The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
    Type: Application
    Filed: May 19, 2017
    Publication date: September 14, 2017
    Applicant: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: MICHAEL HAHN, MARKUS FOLLMANN, EVA-MARIA BECKER, JOHANNES-PETER STASCH, JOERG KELDENICH, MARTINA DELBECK, HANNA TINEL, FRANK WUNDER, JOACHIM MITTENDORF, ILDIKO TEREBESI, DIETER LANG, RENÉ MARTIN, WALTER HÜBSCH
  • Publication number: 20170253602
    Abstract: The present application relates to novel (3-hydroxyphenyl)amino-substituted pyrido[2,3-b][1,5]benzodiazepin-5-one derivatives, to processes for preparation thereof, to the use thereof alone or in combination for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially of angiogenic disorders and hyperproliferative disorders in which neovascularization plays a role, for example ophthalmological disorders and cancers and tumours. Such treatments can be effected as monotherapy or else in combination with other medicaments or further therapeutic measures.
    Type: Application
    Filed: November 23, 2015
    Publication date: September 7, 2017
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Andreas SCHALL, Jürgen KLAR, Mario LOBELL, Hartmut SCHIROK, Joachim TELSER, Steffen MÜLLER, Dirk BROHM, Hans BRIEM, Hannah JÖRIßEN, Joerg KELDENICH (deceased), Michael BÖTTGER, Georges DEGENFELD VON, Thomas SCHLANGE, Ulf BÖMER, Niels LINDNER, Hanna EILKEN, Dmitrij HRISTODOROV, Pierre WASNAIRE, Kersten Matthias GERICKE, Lars BÄRFACKER
  • Patent number: 9687476
    Abstract: The present application relates to novel bisaryl-linked 5-aryl-1,2,4-triazolone derivatives, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
    Type: Grant
    Filed: November 2, 2015
    Date of Patent: June 27, 2017
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Chantal Fürstner, Jörg Keldenich, Martina Delbeck, Peter Kolkhof, Axel Kretschmer, Ingo Pluschkell, Elisabeth Pook, Carsten Schmeck, Hubert Trübel
  • Patent number: 9688636
    Abstract: The present application relates to novel 5-amino-5,6,7,8-tetrahydroquinoline-2-carboxylic acids, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular and cardiopulmonary disorders.
    Type: Grant
    Filed: January 29, 2015
    Date of Patent: June 27, 2017
    Assignee: BAYER PHARMA AKTIENGESELLSCHAFT
    Inventors: Michael Hahn, Markus Follmann, Walter Hübsch, Eva-Maria Becker, Johannes-Peter Stasch, Joerg Keldenich, Martina Delbeck, Hanna Tinel, Frank Wunder, Joachim Mittendorf, Ildiko Terebesi, Dieter Lang, René Martin
  • Patent number: 9624199
    Abstract: The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
    Type: Grant
    Filed: December 16, 2014
    Date of Patent: April 18, 2017
    Assignee: Bayer Pharma Aktiengesellschaft
    Inventors: Eva Maria Becker-Pelster, Philipp Buchgraber, Anja Buchmüller, Karen Engel, Andreas Göller, Herbert Himmel, Raimund Kast, Joerg Keldenich, Carsten Schmeck, Hanna Tinel, Frank Wunder
  • Publication number: 20160318866
    Abstract: The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardiac vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
    Type: Application
    Filed: December 16, 2014
    Publication date: November 3, 2016
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Eva Maria BECKER-PELSTER, Philipp BUCHGRABER, Anja BUCHMÜLLER, Karen ENGEL, Mark Jean GNOTH, Herbert HIMMEL, Raimund KAST, Joerg KELDENICH, Jürgen KLAR, Andreas KNORR, Dieter LANG, Niels LINDNER, Carsten SCHMECK, Rudolf SCHOHE-LOOP, Hanna TINEL, Hubert TRÜBEL, Frank WUNDER
  • Publication number: 20160304492
    Abstract: The invention relates to novel substituted bipiperidinyl derivatives, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of diabetic microangiopathies, diabetic ulcers on the extremities, in particular for promoting wound healing of diabetic foot ulcers, diabetic heart failure, diabetic coronary microvascular heart disorders, peripheral and cardial vascular disorders, thromboembolic disorders and ischaemias, peripheral circulatory disturbances, Raynaud's phenomenon, CREST syndrome, microcirculatory disturbances, intermittent claudication, and peripheral and autonomous neuropathies.
    Type: Application
    Filed: December 16, 2014
    Publication date: October 20, 2016
    Applicant: Bayer Pharma Aktiengesellschaft
    Inventors: Eva Maria BECKER-PELSTER, Philipp BUCHGRABER, Anja BUCHMÜLLER, Karen ENGEL, Andreas GÖLLER, Herbert HIMMEL, Raimund KAST, Joerg KELDENICH, Carsten SCHMECK, Hanna TINEL, Frank WUNDER
  • Publication number: 20160229858
    Abstract: The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
    Type: Application
    Filed: September 25, 2015
    Publication date: August 11, 2016
    Inventors: Kai THEDE, Ingo FLAMME, Felix OEHME, Jens-Kerim ERGÜDEN, Friederike STOLL, Joachim SCHUHMACHER, Hanno WILD, Peter KOLKHOF, Hartmut BECK, Jörg KELDENICH, Metin AKBABA, Mario JESKE
  • Publication number: 20160130230
    Abstract: The present application relates to novel substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Application
    Filed: November 16, 2015
    Publication date: May 12, 2016
    Applicant: Bayer Intellectual Property GmbH
    Inventors: Alexandros VAKALOPOULOS, Daniel MEIBOM, Peter NELL, Frank SÜßMEIER, Barbara ALBRECHT-KÜPPER, Katja ZIMMERMANN, Joerg KELDENICH, Dirk SCHNEIDER, Ursula KRENZ
  • Publication number: 20160051518
    Abstract: The present application relates to novel bisaryl-linked 5-aryl-1,2,4-triazolone derivatives, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
    Type: Application
    Filed: November 2, 2015
    Publication date: February 25, 2016
    Applicant: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Chantal FÜRSTNER, Jörg KELDENICH, Martina DELBECK, Peter KOLKHOF, Axel KRETSCHMER, Ingo PLUSCHKELL, Elisabeth POOK, Carsten SCHMECK, Hubert TRÜBEL
  • Patent number: 9205077
    Abstract: The present application relates to novel 2-alkoxy-substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prevention of cardiovascular disorders.
    Type: Grant
    Filed: June 13, 2014
    Date of Patent: December 8, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Walter Hübsch, Daniel Meibom, Alexandros Vakalopoulos, Barbara Albrecht-Küpper, Peter Nell, Katja Zimmermann, Frank Süβmeier, Joerg Keldenich
  • Publication number: 20150328145
    Abstract: The present invention relates to topical ophthalmological pharmaceutical compositions containing regorafenib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof but without hydrophobic silica and its process of preparation and its use for treating ophthalmological disorders.
    Type: Application
    Filed: December 21, 2013
    Publication date: November 19, 2015
    Applicant: BAYER HEALTHCARE LLC
    Inventors: Michael BOTTGER, Georges VON DEGENFELD, Julia FREUNDLIEB, Claudia HIRTH-DIETRICH, Joerg KELDENICH, Jurgen KLAR, Uwe MUENSTER, Andreas OHM, Annett RICHTER, Bernd RIEDL
  • Patent number: 9187428
    Abstract: The present application relates to novel substituted dicyanopyridines, to processes for their preparation, to their use for the treatment and/or prophylaxis of diseases and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, preferably for the treatment and/or prophylaxis of cardiovascular disorders.
    Type: Grant
    Filed: June 27, 2011
    Date of Patent: November 17, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Alexandros Vakalopoulos, Daniel Meibom, Peter Nell, Frank Sussmeier, Barbara Albrecht-Kupper, Katja Zimmermann, Joerg Keldenich, Dirk Schneider, Ursula Krenz
  • Patent number: 9187466
    Abstract: The present invention relates to bisaryl-linked 5-aryl-1,2,4-triazolone derivatives according to the following formula: wherein Ar1, Ar2, R1, R2, L1, L2, Q and n are defined herein. The invention further related to the process of making the bisaryl-linked 5-aryl-1,2,4-triazolone derivatives.
    Type: Grant
    Filed: February 25, 2011
    Date of Patent: November 17, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Chantal Furstner, Joerg Keldenich, Martina Delbeck, Peter Kolkhof, Axel Kretschmer, Ingo Pluschkell, Elisabeth Pook, Carsten Schmeck, Hubert Trubel
  • Patent number: 9180120
    Abstract: The present application relates to novel substituted N-phenethyltriazoloneacetamides, to processes for preparing them, to their use alone or in combinations for the treatment and/or prevention of diseases and also to their use for the production of medicaments for the treatment and/or prevention of diseases, more particularly for the treatment and/or prevention of cardiovascular disorders.
    Type: Grant
    Filed: August 31, 2011
    Date of Patent: November 10, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Chantal Fürstner, Joerg Keldenich, Martina Delbeck, Peter Kolkhof, Axel Kretschmer, Elisabeth Pook, Carsten Schmeck, Hubert Trübel
  • Patent number: 9168249
    Abstract: The present application relates to novel substituted dihydropyrazolone derivatives, processes for their preparation, their use for treatment and/or prophylaxis of diseases and their use for the preparation of medicaments for treatment and/or prophylaxis of diseases, in particular cardiovascular and hematological diseases and kidney diseases, and for promoting wound healing.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: October 27, 2015
    Assignee: Bayer Intellectual Property GmbH
    Inventors: Kai Thede, Ingo Flamme, Felix Oehme, Jens-Kerim Ergüden, Friederike Stoll, Joachim Schuhmacher, Hanno Wild, Peter Kolkhof, Hartmut Beck, Jörg Keldenich, Metin Akbaba, Mario Jeske
  • Publication number: 20150174096
    Abstract: The present invention relates to topical ophthalmological pharmaceutical compositions containing sunitinib, a hydrate, solvate or pharmaceutically acceptable salt thereof or a polymorph thereof and its process of preparation and its use for treating ophthalmological disorders.
    Type: Application
    Filed: June 10, 2013
    Publication date: June 25, 2015
    Applicant: Bayer Healthcare LLC
    Inventors: Michael Bottger, Georges Von Degenfeld, Julia Freundlieb, Claudia Hirth-Dietrich, Joerg Keldenich, Jurgen Klar, Uwe Muenster, Andreas Ohm, Annett Richter, Bernd Riedl, Joachim Telser