Patents by Inventor Joerg Kley

Joerg Kley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Patent number: 7160901
    Abstract: Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumor cells, and inhibitors of protein kinases.
    Type: Grant
    Filed: August 22, 2003
    Date of Patent: January 9, 2007
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • INDOLINE DERIVATIVES SUBSTITUTED IN THE 6 POSITION, THEIR PREPARATION AND THEIR USE AS MEDICAMENTS
    Publication number: 20070004757
    Abstract: The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R1 to R6 and X are as defined in Claim 1, to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.
    Type: Application
    Filed: September 7, 2006
    Publication date: January 4, 2007
    Inventors: Gerald Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley, Frank Hilberg, Jacobus Van Meel, Ulrik Tontsch-Grunt
  • Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
    Patent number: 7148249
    Abstract: The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: September 5, 2003
    Date of Patent: December 12, 2006
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Joerg Kley, Frank Hilberg, Armin Heckel, Gerald Juergen Roth, Thorsten Lehmann-Lintz, Ralf R. H. Lotz, Ulrike Tontsch-Grunt, Jacobus C. A. Van Meel
  • Compounds for the treatment of inflammatory diseases
    Publication number: 20060258861
    Abstract: Compounds of formula 1 and hetero derivatives thereof and the pharmacologically acceptable salts, enantiomers, racemates, hydrates, or solvates thereof, which are suitable for the treatment of respiratory or gastrointestinal complaints or diseases, inflammatory diseases of the joints, skin, or eyes, diseases of the peripheral or central nervous system or cancers, as well as pharmaceutical compositions which contain these compounds.
    Type: Application
    Filed: April 21, 2006
    Publication date: November 16, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Ralf Anderskewitz, Horst Dollinger, Rolf Goeggel, Birgit Jung, Joerg Kley, Juergen Mack, Peter Nickolaus, Rainer Walter
  • Indolinone derivatives substituted in the 6 position, the preparation thereof and their use as pharmaceutical compositions
    Publication number: 20060194813
    Abstract: The present invention relates to indolinone derivatives substituted in the 6 position of general formula wherein R1 to R6 and X are defined as in claim 1, the tautomers, enantiomers, diastereomers, mixtures thereof and the salts thereof, particularly the physiologically acceptable salts thereof, which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Application
    Filed: July 22, 2003
    Publication date: August 31, 2006
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Armin Heckel, Frank Hilberg, Thorsten Lehmann-Lintz, Guenter Linz, Joerg Kley, Jacobus Van Meel, Werner Rall, Gerald Roth, Peter Sieger, Ulrike Tontsch-Grunt
  • Medicaments for the Treatment or Prevention of Fibrotic Diseases
    Publication number: 20060154939
    Abstract: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.
    Type: Application
    Filed: December 20, 2005
    Publication date: July 13, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: John Park, Nveed Chaudhary, Thorsten Lehmann-Lintz, Armin Heckel, Gerald Roth, Joerg Kley, Trixi Brandl, Georg Dahmann, Matthias Grauert
  • Medicaments for the Treatment or Prevention of Fibrotic Diseases
    Publication number: 20060148883
    Abstract: The present invention relates to the use of indolinones of general formula substituted in the 6 position, wherein R1 to R6 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof, as a medicament for the prevention or treatment of specific fibrotic diseases.
    Type: Application
    Filed: December 20, 2005
    Publication date: July 6, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: John Park, Nveed Chaudhary, Gerald Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley
  • Indolinones and their use as antiproliferative agents
    Publication number: 20060135592
    Abstract: The invention relates to indolinone compounds of formula (I), wherein Y and R1 to R8 are defined as in claim 1, which are suitable for the treatment of diseases characterized by excessive or abnormal cell proliferation and the use thereof for preparing a pharmaceutical composition.
    Type: Application
    Filed: December 16, 2005
    Publication date: June 22, 2006
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Darryl McConnell, Ulrike Weyer-Czernilofsky, Maria Impagnatiello, Steffen Steurer, Ralph Brueckner, Bernd Krist, Bodo Betzemeier, Frank Hilberg, Armin Heckel, Gerald Roth, Joerg Kley, Thorsten Lehmann-Lintz
  • Aryl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Publication number: 20050234120
    Abstract: The present invention relates to aryl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Application
    Filed: March 10, 2005
    Publication date: October 20, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues
  • Alkyl-containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Publication number: 20050209302
    Abstract: The present invention relates to alkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined herein, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Application
    Filed: March 10, 2005
    Publication date: September 22, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues
  • Cycloalkyl - containing 5-acylindolinones, the preparation thereof and their use as medicaments
    Publication number: 20050203104
    Abstract: The present invention relates to cycloalkyl-containing 5-acylindolinones of general formula wherein R1 to R3 are defined as in claims 1 to 6, the tautomers, the enantiomers, the diastereomers, the mixtures thereof and the salts thereof, which have valuable pharmacological properties, particularly an inhibiting effect on protein kinases, particularly an inhibiting effect on the activity of glycogen synthase kinase (GSK-3).
    Type: Application
    Filed: March 10, 2005
    Publication date: September 15, 2005
    Applicant: Boehringer Ingelheim International GmbH
    Inventors: Armin Heckel, Gerald Roth, Joerg Kley, Stefan Hoerer, Ingo Uphues
  • Indolinones substituted by heterocycles, the preparation thereof and their use as medicaments
    Publication number: 20050054710
    Abstract: The present invention relates to heterocyclically substituted indolinones of general formula wherein R1 to R5 and X are defined as in claim 1, the tautomers, the diastereomers, the enantiomers, the mixtures thereof, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various tumour cells, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Application
    Filed: September 5, 2003
    Publication date: March 10, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Joerg Kley, Frank Hilberg, Armin Heckel, Gerald Roth, Thorsten Lehmann-Lintz, Ralf Lotz, Ulrike Tontsch-Grunt, Jacobus Van Meel
  • Indoline derivatives substituted in the 6 position, their preparation and their use as medicaments
    Publication number: 20050043389
    Abstract: The present invention relates to indolinone derivatives, substituted in the 6-position, of the formula in which R1 to R6 and X are as defined in claim 1, to their tautomers, enantiomers, diastereomers, to their mixtures and to their salts, in particular their physiologically acceptable salts, which have useful pharmacological properties, in particular in inhibiting action on various receptor tyrosine kinases and on the proliferation of endothelial cells and various tumour cells, to medicaments comprising these compounds, to their use and to processes for their preparation.
    Type: Application
    Filed: July 22, 2003
    Publication date: February 24, 2005
    Applicant: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Gerald Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley, Frank Hilberg, Jacobus Van Meel, Ulrike Tontsch-Grunt
  • Substituted indolinones
    Patent number: 6858641
    Abstract: The present invention relates to indolinones substituted in the 6-position of general formula wherein R1 to R5 and X are defined as in claim 1, the isomers and the salts thereof, particularly the physiologically acceptable salts thereof which have valuable pharmacological properties, in particular an inhibiting effect on various receptor tyrosine kinases and cyclin/CDK complexes and on the proliferation of endothelial cells and various, pharmaceutical compositions containing these compounds, their use and processes for preparing them.
    Type: Grant
    Filed: April 4, 2002
    Date of Patent: February 22, 2005
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Gerald Juergen Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley, Frank Hilberg, Jacobus Van Meel
  • New substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Publication number: 20040044053
    Abstract: Indolinones of general formula I 1
    Type: Application
    Filed: August 22, 2003
    Publication date: March 4, 2004
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • New substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Publication number: 20040044222
    Abstract: Indolinones of general formula I 1
    Type: Application
    Filed: August 22, 2003
    Publication date: March 4, 2004
    Applicant: Boehringer Ingelheim Pharma KG
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • Substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Patent number: 6638965
    Abstract: Indolinones of general formula I which are inhibitors of cell proliferation, particularly of tumour cells, and inhibitors of protein kinases. The following compounds are exemplary: (Z)-3-{1-[4-(N-(2-aminoethyl)-N-methylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-5-phenylsulphonylamino-2-indolinone, (Z)-3-{1-[4-(N-(2-dimethylaminoethyl)-N-phenylsulphonyl-amino)-phenylamino]-1-phenyl-methylidene}-5-phenylsulphonylamino-2-indolinone, and (Z)-3-{1-[4-(4-methylpiperazinomethyl)-phenylamino]-1-phenyl-methylidene}-5-phenylsulphonylamino-2-indolinone.
    Type: Grant
    Filed: November 1, 2001
    Date of Patent: October 28, 2003
    Assignee: Boehringer Ingelheim Pharma KG
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky
  • Substituted indolinones
    Publication number: 20030092756
    Abstract: The present invention relates to indolinones substituted in the 6-position of general formula 1
    Type: Application
    Filed: April 4, 2002
    Publication date: May 15, 2003
    Inventors: Gerald Juergen Roth, Armin Heckel, Thorsten Lehmann-Lintz, Joerg Kley, Frank Hilberg, Jacobus Van Meel
  • Substituted indolinones, preparation thereof and their use as pharmaceutical compositions
    Publication number: 20030069299
    Abstract: Indolinones of general formula I 1
    Type: Application
    Filed: November 1, 2001
    Publication date: April 10, 2003
    Inventors: Rainer Walter, Armin Heckel, Gerald Roth, Joerg Kley, Gisela Schnapp, Martin Lenter, Jacobus Van Meel, Walter Spevak, Ulrike Weyer-Czernilofsky