Abstract: The aim of the invention is to optimize the running smoothness of an internal combustion engine. To achieve this aim, the individual cylinders are synchronized with respect to their torque contribution. According to the method, fuel is injected into the combustion chamber of a cylinder in at least one injection step, the at least one injection contributing to the torque of the internal combustion engine. Fuel is injected into the combustion chamber of the cylinder in a torque neutral manner by way of a secondary injection during a working stroke of the cylinder and the amount of fuel of the secondary injection us calculated in such a manner that the exhaust gas substantially corresponds to a stoichiometric air/fuel mixture.

Abstract: Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably its use for the identification of transport inhibitors, e.g. drug candidates.

Abstract: Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably its use for the identification of transport inhibitors, e.g. drug candidates.