Abstract: A multi chamber syringe unit (1) comprises a body (2), a separating element (3) and a bypass arrangement (26). The body (2) has a distal end side (23), a proximal end side (22) opposite to the distal end side (23), an interior limited by a side wall (21) between the distal end side (23) and the proximal end side (22) and a longitudinal axis (27) centrally extending from the distal end side (23) to the proximal end side (22) through the body. The separating element (3) is arranged in the interior of the body (2) forming a distal chamber (24) between the distal end side (23) and the separating element (3) and a proximal chamber (25) between the proximal end side (22) and the separating element (3). The bypass arrangement (26; 260; 268; 269) is a section of the body (2) in which the interior has a constant noncircular cross section (261) orthogonal to the longitudinal axis (27).

Abstract: A multi chamber syringe unit includes a longitudinal body with side wall, distal end side, proximal end side opposite to distal end side, an interior limited by side wall between distal end side and proximal end side and distal opening arranged in distal end side for providing a liquid out of the body. The syringe further includes a separating element arranged in the interior of the body such that distal chamber and proximal chamber are formed in the interior of the body, wherein the separating element seals the distal chamber from the proximal chamber. The syringe has a bypass arrangement provided in the side wall of distal chamber of the body. A first pharmaceutical liquid is arranged in distal chamber of the body and second pharmaceutical liquid in proximal chamber of the body. The multi chamber syringe unit allows for adequately administering plural pharmaceutical liquids by injection.

Abstract: A method for providing a dried solid product containing an active pharmaceutical ingredient is disclosed and includes providing a primary packaging container, providing a drying cartridge different from the primary packaging container, the drying cartridge made of a material adapted to hold a liquid product to be dried, wherein the liquid product contains an active pharmaceutical ingredient and the drying cartridge is made of a material having a thermal conductivity higher than the thermal conductivity of glass. The method also includes filling the liquid product into the drying cartridge, drying the liquid product in the drying cartridge to form a dried solid product containing the active pharmaceutical ingredient, transferring the dried solid product into the primary packaging container.

Abstract: A method of preparing a double chamber container (1) comprises the steps of: filling a substance in the interior of the double chamber container (1), freeze-drying the substance inside the double chamber container(1), inserting a middle plunger (81) in the interior of the double chamber container (1) such that a distal chamber and a proximal chamber are formed, wherein the middle plunger (81) seals the distal chamber from the proximal chamber and wherein the freeze-dried substance is inside the distal chamber, filling a reconstitution medium in the proximal chamber of the double chamber container (1), and sealing a distal opening (14) of the double chamber container (1) and a proximal opening (13) of the double chamber container (1).

Abstract: A device (1) for closing a chamber of a container having an opening for accessing the chamber comprises a plunger, a plunger seat (11), a container carrier (13) and a spacer (12). The plunger seat (11) releasably holds the plunger in a predefined alignment. The container carrier (13) is arranged to be connected to the container in a predefined position and alignment in relation to the opening of the container. The spacer (12) is arranged to position and align the plunger seat (11) adjacent to and distant from the container carrier (13) such that the opening of the container is open when the container is connected to the container carrier (13).

Abstract: A peristaltic dosing device for providing dosages of a fluid at a volume of less than one milliliter comprises: a flexible tube, a counter pressure element, a plurality of actors and a drive. The flexible tube is essentially straightly arranged along the counter pressure element thereby forming a longitudinal axis. The actors arranged parallel to each other along the longitudinal axis. They are moveable by the drive in relation to the flexible tube. The flexible tube is compressible between the actors and the counter pressure element by moving the actors. Each of the actors is independently and linearly moveable by the drive along an actuation axis essentially perpendicular to the longitudinal axis of the flexible tube from a home position in which the flexible tube is least compressed to an end position in which the flexible tube is compressed and sealed between the respective actor and the counter pressure element.

Abstract: A method for determining whether reconstitution of a solution in a container is completed comprises the steps of: selecting a predetermined amount of a solid substance and a predetermined amount of a liquid solvent from which the reconstituted solution is to be prepared, preparing a solution by solving the predetermined amount of the solid substance in the predetermined amount of the liquid solvent, measuring the impedance (Z) or the resistance (R) of the solution, determining whether the change of the measured impedance (Z) or the resistance (R) within a measuring time interval of a predetermined duration is below a defined threshold, and determining that reconstitution of the solution is completed when the change of the measured impedance (Z) is below the defined threshold.

Abstract: The invention relates to an apparatus for testing the integrity of packaging containers, comprising a detector (9) for the detection of an ultrasound signal generated by gas flow through a leak in a pressurized packaging container (3), characterized in that the apparatus comprises a test chamber (2) suitable for accommodation of a pressurized packaging container (3) and the detector (9) being arranged such that it is to detect a gas-borne ultrasound signal generated by gas flow through a leak in a pressurized packaging container (3) inside the test chamber (2).

Abstract: Devices and methods are disclosed which automatically reconstitute a drug, such as e.g., a lyophilized drug. A vial (30) containing the drug is fluidly coupled to a cartridge (12) containing a reconstitution liquid with a fluid conduit (14f), wherein an entry point is defined where the fluid conduit enters the vial (30). The device (10) automatically adjusts orientation of the vial (30) such that the entry point of the vial is gravitationally higher than the drug in the vial (30), and automatically transfers the reconstitution liquid out of the cartridge (12) and into the vial (30) to create a reconstituted drug. The device (10) also automatically adjusts the orientation of the vial (30) such that the entry point of the vial is gravitationally lower than the reconstituted drug, and automatically transfers the reconstituted drug from the vial (30) and into the cartridge (12).

Abstract: A freeze-drying device for the monitoring and control of water vapor in a freeze-drying process, comprising an optical spectrometer, and methods of using same to monitor and control the amount of water vapor in said process under sterile conditions.

Abstract: The invention relates to an apparatus for monitoring the water vapor in a freeze-drying process of, for example, pharmaceutical products.