Patents by Inventor Joerg Ogorka
Joerg Ogorka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11642315Abstract: A method of preparing a pharmaceutical product comprises the steps of (a) providing a neat active pharmaceutical ingredient (API) complying with at least five of the following parameters determined by using a FT4 powder rheometer: (i) specific basic flow energy of at most 60 mJ/g; (ii) stability index of 0.75 to 1.25; (iii) specific energy of at most 10 mJ/g; (iv) major principle stress at 15 kPa of at most 40; (v) flow function at 15 kPa of at least 1.3; (vi) consolidated bulk density at 15 kPa of at least 0.26 g/mL; (vii) compressibility of at most 47%; and (viii) wall friction angle of at most 40°; (b) dispensing the neat API of step (a) into a bottom part of a pharmaceutical carrier using a vacuum assisted metering and filling device; and (c) encapsulating the bottom part, thereby producing a pharmaceutical product.Type: GrantFiled: September 28, 2018Date of Patent: May 9, 2023Assignee: Novartis AGInventors: Elodia Di Renzo, David Hook, Markus Krumme, Steffen Lang, Massimo Moratto, Joerg Ogorka, Jim Parks, Dale Ploeger, Norbert Rasenack, Hendrik Schneider, Stefan Steigmiller, Gordon Stout, Patrick Tritschler, Fabian Weber
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Publication number: 20220202728Abstract: A formulation for injection moulding of a pharmaceutical carrier comprising 27-85% (w/w) of polyvinyl alcohol, and 10-60% (w/w) of a disintegration aid selected from maize starch, wheat starch, and combinations thereof; and optionally one or more excipients.Type: ApplicationFiled: April 1, 2020Publication date: June 30, 2022Inventors: Florian BECK, Hans de Waard, Sarah Gold, Stefan Hirsch, David Hook, Nikhil Kavimandan, Markus Krumme, Steffen Lang, Detlef MOLL, Siddharthya Mujumdar, Anh-Thu Nguyen-Trung, Joerg Ogorka, Norbert Rasenack, Maxime Thomas-Schrapp, Raphael TOBLER, Patrick Tritschler
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Publication number: 20220175682Abstract: The present invention relates to methods of preparing pharmaceutical products, involving filling active pharmaceutical ingredient powders into pharmaceutical carriers with a vacuum assisted metering and filling device. The methods disclosed herein can be used in a continuous process, such as in a high-throughput process for producing a pharmaceutical product. The present invention further relates to a particular quality of the neat active pharmaceutical ingredient (API) HDM201, i.e. siremadlin, present as succinic acid co-crystal, which can be used in the methods of preparation of the present invention.Type: ApplicationFiled: April 2, 2020Publication date: June 9, 2022Inventors: Nicole BIERI, Elodia DI RENZO, David HOOK, Jennifer Claire HOOTON, Markus KRUMME, Steffen LANG, Franck MALLET, Massimo MORATTO, Joerg OGORKA, Jim PARKS, Dale W. PLOEGER, Norbert RASENACK, Hendrik SCHNEIDER, Lipa SHAH, Stefan STEIGMILLER, Gordon STOUT, Patrick TRITSCHLER, Fabian WEBER
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Publication number: 20200315973Abstract: A method of preparing a pharmaceutical product comprises the steps of (a) providing a neat active pharmaceutical ingredient (API) complying with at least five of the following parameters determined by using a FT4 powder rheometer: (i) specific basic flow energy of at most 60 mJ/g; (ii) stability index of 0.75 to 1.25; (iii) specific energy of at most 10 mJ/g; (iv) major principle stress at 15 kPa of at most 40; (v) flow function at 15 kPa of at least 1.3; (vi) consolidated bulk density at 15 kPa of at least 0.26 g/mL; (vii) compressibility of at most 47%; and (viii) wall friction angle of at most 40°; (b) dispensing the neat API of step (a) into a bottom part of a pharmaceutical carrier using a vacuum assisted metering and filling device; and (c) encapsulating the bottom part, thereby producing a pharmaceutical product.Type: ApplicationFiled: September 28, 2018Publication date: October 8, 2020Inventors: Elodia Di Renzo, David Hook, Markus Krumme, Steffen Lang, Massimo Moratto, Joerg Ogorka, Jim Parks, Dale Ploeger, Norbert Rasenack, Hendrik Schneider, Stefan Steigmiller, Gordon Stout, Patrick Tritschler, Fabian Weber
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Publication number: 20200306198Abstract: A formulation for injection molding of a pharmaceutical carrier comprises 43.5-97% (w/w) of one or more polyethylene oxide polymer having a weight average molecular weight of MW 94,000-188,000; and optionally one or more excipients.Type: ApplicationFiled: September 28, 2018Publication date: October 1, 2020Inventors: Florian Beck, Hans de Waard, Sarah Gold, Stefan Hirsch, David Hook, Nikhil Kavimandan, Markus Krumme, Steffen Lang, Detlef Moll, Siddharthya Mujumdar, Anh-Thu Nguyen-Trung, Joerg Ogorka, Norbert Rasenack, Raphael Tobler, Patrick Tritschler
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Publication number: 20200246272Abstract: A pharmaceutical carrier (20) comprises a lid part (22) and a bottom part (24), wherein at least one of the lid part (22) and the bottom part (24) has a first wall section (26, 30) with a thickness of 180-250 ?m, preferably 185-225 ?m, even more preferably 190-220 ?m, and most preferably about 215 ?m, and a second wall section (28, 32) with a thickness of 350-450 ?m, preferably 375-425 ?m, more preferably 390-410 ?m, and most preferably about 400 ?m. The first wall section (26) of the lid part (22) defines an entire top portion of the lid part (22). Alternatively or additionally thereto, the first wall section (30) of the bottom part (24) defines an entire bottom portion of the bottom part (24).Type: ApplicationFiled: September 28, 2018Publication date: August 6, 2020Inventors: Florian Beck, Hans de Waard, Sarah Gold, Stefan Hirsch, David Hook, Nikhil Kavimandan, Markus Krumme, Steffen Lang, Detlef Moll, Siddharthya Mujumdar, Anh-Thu Nguyen-Trung, Joerg Ogorka, Norbert Rasenack, Raphael Tobler, Patrick Tritschler
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Publication number: 20160101105Abstract: The present invention pertains to a high drug load tablet comprising as active ingredient Compound I of formula or a pharmaceutically acceptable salt thereof in an amount from about 30% to 80% in weight of the active moiety based on the total weight of the tablet.Type: ApplicationFiled: December 18, 2015Publication date: April 14, 2016Inventors: Christian-Peter LUFTENSTEINER, Jean-Claude BIANCHI, Joerg OGORKA, Oskar KALB
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Publication number: 20150209291Abstract: The present invention pertains to a high drug load tablet comprising as active ingredient Compound I of formula or a pharmaceutically acceptable salt thereof in an amount from about 30% to 80% in weight of the active moiety based on the total weight of the tablet.Type: ApplicationFiled: April 6, 2015Publication date: July 30, 2015Applicant: Novartis AGInventors: Christian-Peter LUFTENSTEINER, Jean-Claude BIANCHI, Joerg OGORKA, Oskar KALB
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Patent number: 9011911Abstract: The present invention pertains to a high drug load tablet comprising an active ingredient Compound I of formula or a pharmaceutically acceptable salt thereof in an amount from about 30% to 80% in weight of the active moiety based on the total weight of the tablet.Type: GrantFiled: January 23, 2014Date of Patent: April 21, 2015Assignee: Novartis AGInventors: Christian-Peter Luftensteiner, Jean-Claude Bianchi, Joerg Ogorka, Oskar Kalb
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Patent number: 8841303Abstract: The invention provides a dosage form, comprising a melt-processed mixture of (a) a pharmaceutically effective amount of imatinib or a salt thereof, (b) at least one polymeric binder, and (c) at least one pharmaceutically acceptable non-ionic surfactant. The invention provides imatinib dosage forms with high drug loading which can be prepared in a simple and efficient manner, imatinib dosage forms from which the active principle is released in an essentially pH-independent fashion, and extended release imatinib dosage forms.Type: GrantFiled: November 8, 2007Date of Patent: September 23, 2014Assignees: Abbvie Deutschland GmbH & Co. KG, Novartis AGInventors: Jörg Breitenbach, Norbert Steiger, Harald Hach, Ulrich Westedt, Martin Knobloch, Ralf Altenburger, Nicoletta Loggia, Jörg Ogorka
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Publication number: 20140135340Abstract: The present invention pertains to a high drug load tablet comprising an active ingredient Compound I of formula or a pharmaceutically acceptable salt thereof in an amount from about 30% to 80% in weight of the active moiety based on the total weight of the tablet.Type: ApplicationFiled: January 23, 2014Publication date: May 15, 2014Applicant: Novartis AGInventors: Christian-Peter Luftensteiner, Jean-Claude Bianchi, Joerg Ogorka, Oskar Kalb
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Publication number: 20120177737Abstract: The present invention pertains to a high drug load tablet comprising as active ingredient Compound I of formula or a pharmaceutically acceptable salt thereof in an amount from about 30% to 80% in weight of the active moiety based on the total weight of the tablet.Type: ApplicationFiled: March 19, 2012Publication date: July 12, 2012Inventors: Christian-Peter LUFTENSTEINER, Jean-Claude BIANCHI, Jörg OGORKA, Oskar KALB
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Publication number: 20110038897Abstract: This invention relates to methods to prevent worsening of and/or to improve cognitive functioning and behaviour problems in patients with dementia by means of ApoE genotyping to guide the use of AChEI drugs, including rivastigimine. Also included are kits for determining ApoE4 status and recommended treatment strategy.Type: ApplicationFiled: October 27, 2010Publication date: February 17, 2011Inventors: Rajen SHAH, Satish Chandra Khanna, Oskar Kalb, Jörg Ogorka
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Publication number: 20100240672Abstract: The invention provides a dosage form, comprising a melt-processed mixture of (a) a pharmaceutically effective amount of imatinib or a salt thereof, (b) at least one polymeric binder, and (c) at least one pharmaceutically acceptable non-ionic surfactant. The invention provides imatinib dosage forms with high drug loading which can be prepared in a simple and efficient manner, imatinib dosage forms from which the active principle is released in an essentially pH-independent fashion, and extended release imatinib dosage forms.Type: ApplicationFiled: November 8, 2004Publication date: September 23, 2010Applicants: ABBOTT GMBH & CO. KG, NOVARTIS AGInventors: Jorg Breitenbach, Norbert Steiger, Harald Hach, Ulrich Westedt, Martin Knobloch, Ralf Altenburger, Nicoletta Loggia, Jörg Ogorka
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Publication number: 20100233253Abstract: An extended release gastro-retentive drug delivery system of Valsartan. The drug delivery system contains a release portion containing the Valsartan, a gastro-retentive portion for retaining the drug delivery system in the stomach and an optional secondary portion for delivering a secondary pulse of Valsartan. In another embodiment, there is provided a swellable unfolding membrane comprising Valsartan for sustained administration of Valsartan to the upper GI tract of a patient.Type: ApplicationFiled: August 29, 2007Publication date: September 16, 2010Applicant: Novartis AGInventors: Nikhil Javant Kavimandan, Jay Parthiban Lakshman, Arnol Singh Matharu, Joerg Ogorka, Alan Edward Royce, Noel Raj Teelucksingh
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Publication number: 20100203133Abstract: The present invention pertains to a high drug load tablet comprising as active ingredient Compound I of formula or a pharmaceutically acceptable salt thereof in an amount from about 30% to 80% in weight of the active moiety based on the total weight of the tablet.Type: ApplicationFiled: April 21, 2010Publication date: August 12, 2010Applicant: NOVARTIS AGInventors: Christian-Peter LUFTENSTEINER, Jean-Claude Bianchi, Jörg Ogorka, Oskar Kalb
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Publication number: 20100166843Abstract: The present invention relates to pharmaceutical compositions comprising a topoisomerase I inhibitor including, but not limited to, a camptothecin derivative.Type: ApplicationFiled: January 30, 2008Publication date: July 1, 2010Applicant: SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A.Inventors: Giancarlo Francese, Jörg Ogorka, Jia-ai Zhang
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Patent number: 6565883Abstract: Pharmaceutical composition capable of releasing a therapeutically effective dose of active agent, e.g., rivastigamine, in a time-controlled manner.Type: GrantFiled: April 8, 2002Date of Patent: May 20, 2003Assignee: Novartis AGInventors: Jörg Ogorka, Oskar Kalb, Rajen Shah, Satish Chandra Khanna