Patents by Inventor Joerg Rosenberg

Joerg Rosenberg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fast-acting analgesic
    Patent number: 6322816
    Abstract: A fast-acting analgesic comprises as analgesic substance ibuprofen in an adjuvant matrix with a porous structure and a density of greater than 1 and up to 2.5 g/cm3.
    Type: Grant
    Filed: February 1, 2000
    Date of Patent: November 27, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Jürgen Zeidler, Jörg Neumann, Bernd Leipold, Jörg Rosenberg, Gunther Berndl, Jörg Breitenbach, Christiane Vollgraf
  • Slow-release matrix pellets and the production thereof
    Patent number: 6290990
    Abstract: Slow-release matrix pellets with a spherical or lenticular shape and uniform maximum diameters in the range from 0.5 to 4 mm, composed of a) 0.1-87% by weight of at least one biologically active compound, b) 5-50% by weight of at least one water-insoluble polymer, c) 5-45% by weight of at least one lipophilic component as plasticizer for polymer b), d) 3-40% by weight of a natural or semisynthetic gel former, e) 0-50% by weight of one or more conventional formulation aids.
    Type: Grant
    Filed: October 17, 1996
    Date of Patent: September 18, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Sven Grabowski, Joerg Rosenberg, Axel Sanner
  • USE OF LIPIDS AS ADJUVENTS IN THE PRODUCTION OF SOLID MEDICINAL FORMS BY THE MELT EXTRUSION PROCESS
    Publication number: 20010007664
    Abstract: Lipids are used as aids in the production of solid drug forms by melt extrusion.
    Type: Application
    Filed: January 29, 1998
    Publication date: July 12, 2001
    Inventors: JOERG ROSENBERG, JORG BREITENBACH
  • Preparations of non-steroidal analgesics
    Patent number: 6251434
    Abstract: Preparations of non-steroidal analgesics with antipyretic and antiinflammatory effect are obtainable by extrusion and shaping of a melt, comprising, besides one or more active ingredients, a mixture of a) 40-99.5% by weight of a homopolymer of N-vinylpyrrolidone with a Fikentscher K value of 30, b) 0.25-59.75% by weight of a water-soluble copolymer of N-vinylpyrrolidone, and c) 0.25-10% by weight of one or more physiologically acceptable salts of sodium or potassium, where the stated amounts are based on the total of components a), b) and c).
    Type: Grant
    Filed: July 15, 1998
    Date of Patent: June 26, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Jörg Breitenbach, Joerg Rosenberg
  • Process for producing solid dosage forms by extrusion
    Patent number: 6221368
    Abstract: A process for producing solid dose forms by mixing at least one polymeric binder, with or without at least one active ingredient and with or without conventional additives, and shaping the mixture, where at least one of the components is employed in liquid form.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: April 24, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Jörg Breitenbach, Andreas Kleinke, Stephan Kothrade, Joerg Rosenberg
  • Solid medicaments obtained by extrusion of an isomalt-containing polymer-active substance melt
    Patent number: 6187342
    Abstract: The invention relates to solid drug forms obtainable by extrusion with subsequent shaping of a solvent-free melt, comprising, besides one or more active ingredients, A) 10-90% by weight of a melt-processable, water-soluble polymer, B) 5-85% by weight of isomalt, and C) 0-5% by weight of lecithin, where the total of all the ingredients is to be equal to 100% by weight.
    Type: Grant
    Filed: February 24, 1998
    Date of Patent: February 13, 2001
    Assignee: BASF Aktiengesellschaft
    Inventors: Jürgen Zeidler, Joerg Rosenberg, Jörg Neumann, Jörg Breitenbach
  • Production of lenticular tablets by melt calendering
    Patent number: 6132659
    Abstract: The present invention relates to a process for the production of lenticular tablets by melt calendering in which molding rolls with depressions in the shape of segments of an ellipsoid are used. The process according to the invention affords tablets which are easily deflashed and in which the tablet residue to be abraded when there is a displacement between the upper and lower half of the tablet is small.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: October 17, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Joerg Rosenberg, Werner Maier, Jorg Breitenbach
  • Method of producing multi-layer medicaments in solid form for oral or rectal administration
    Patent number: 6120802
    Abstract: The present invention relates to a process for producing multilayer, solid drug forms for oral or rectal administration, which comprises coextrusion of at least two compositions which in each case comprise a thermoplastic, pharmacologically acceptable polymeric binder which is soluble or swellable in a physiological environment, and at least one of which contains a pharmaceutical active ingredient, and shaping the coextruded multilayer material to the required drug form.
    Type: Grant
    Filed: April 15, 1998
    Date of Patent: September 19, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Jorg Breitenbach, Axel Paul Hartl, Jurgen Hofmann, Joerg Rosenberg, Michael Schiessl, Hans Dieter Zettler
  • Transparent rapid release compositions of non-steroidal analgesics
    Patent number: 6063821
    Abstract: Transparent rapid release active substance compositions obtainable by extrusion of melts, containing non-steroidal analgesics, homopolymers of N-vinylpyrrolidone, saccharides or sugar alcohols and sodium or potassium salts.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: May 16, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Jorg Breitenbach, Axel Sanner, Joerg Rosenberg
  • Production of solid drug forms
    Patent number: 6051253
    Abstract: Solid drug forms are produced by mixing and melting at least one pharmacologically acceptable polymeric binder and at least one pharmaceutical active ingredient, with or without conventional pharmaceutical additives, in the absence of a solvent to give a plastic mixture and shaping the mixture to the required drug form by extrusion, where the shaping takes place in two steps, with the extrudate being broken into shaped articles in a first step, and these shaped articles being rounded off in a second step in the plastic state.
    Type: Grant
    Filed: July 1, 1997
    Date of Patent: April 18, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans Dieter Zettler, Michael Schiessl, Jorg Breitenbach, Joerg Rosenberg
  • Process and apparatus for the production of divisible tablets
    Patent number: 6009690
    Abstract: A process for the production of divisible tablets by melt calendering in which two molding rolls are combined together, at least one of which has depressions with at least one bar which extends up to the surface line of the molding roll and forms a score.
    Type: Grant
    Filed: June 18, 1997
    Date of Patent: January 4, 2000
    Assignee: BASF Aktiengesellschaft
    Inventors: Joerg Rosenberg, Werner Maier, Helmut Fricke, Jorg Breitenbach
  • Process for producing solid drug forms having at least two phases
    Patent number: 6001391
    Abstract: A process for producing solid combination tablets which have at least two phases comprises molding a melt of a polymeric binder with or without at least one active ingredient, there being at least one solid product, which may contain an active ingredient incorporated into the still plastic composition during the molding step.
    Type: Grant
    Filed: March 10, 1998
    Date of Patent: December 14, 1999
    Assignee: Basf Aktiengesellschaft
    Inventors: Jurgen Zeidler, Joerg Rosenberg, Jorg Breitenbach, Andreas Kleinke, Werner Maier
  • Preparation of salts of pharmaceutical active substances which have acidic groups
    Patent number: 5969181
    Abstract: A process for preparing salts of pharmaceutical active substances which have acidic groups by reacting the carboxylic acids with a base in the melt, wherein the acids are reacted with at least the stoichiometric amount of a base in an extruder.
    Type: Grant
    Filed: June 10, 1997
    Date of Patent: October 19, 1999
    Inventors: Jorg Breitenbach, Joerg Rosenberg, Jorg Neumann, Jurgen Zeidler, Dirk Simon, Ralph Diener
  • Storage-stable drug form
    Patent number: 5945127
    Abstract: Solid drug forms obtainable by extrusion of a melt comprising, besides one or more active substances, a mixture of homo- and/or copolymers of N-vinylpyrrolidone and degraded starches.
    Type: Grant
    Filed: September 16, 1997
    Date of Patent: August 31, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Jorg Breitenbach, Jens Rieger, Joerg Rosenberg, Axel Sanner
  • Solid active extrusion compound preparations containing low-substituted hydroxypropylcellulose
    Patent number: 5939099
    Abstract: Solid preparations are obtainable by melt extrusion ofA) at least one active compound,B) a mixture ofB1) from 10 to 90% by weight of a water-soluble, thermoplastic polymer, andB2) from 10 to 90% by weight of a low-substituted hydroxypropylcellulose, andC) from 0 to 50% by weight, based on the total amount of the preparation, of customary pharmaceutical auxiliaries.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: August 17, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Sven Grabowski, Jorg Breitenbach, Joerg Rosenberg, Axel Sanner
  • Production of covered tablets
    Patent number: 5897910
    Abstract: The present invention is a process for the production of covered tablets by melt calendering in which the melt containing active ingredient is introduced between two sheets of the covering material into the molding rolls.
    Type: Grant
    Filed: June 20, 1997
    Date of Patent: April 27, 1999
    Assignee: BASF Aktiengesellschaft
    Inventors: Joerg Rosenberg, Werner Maier, Sven Grabowski, Jorg Breitenbach
  • Preparation of colloidal aqueous solutions of active substances of low solubility and a lipid therefor
    Patent number: 5849941
    Abstract: A process for producing solutions of active substances of low solubility, which comprises (1) dissolving the active substance with a phospholipid and a water-soluble lipid in an organic solvent, (2) evaporating the resulting solution to dryness, (3) taking up the residue in a strongly acidic buffer and stirring at elevated temperature until a colloidal solution is produced, (4) cooling the colloidal solution and adjusting to a pH of 6-7 and sterilizing. Particularly suitable for the process are lipids of the formula ##STR1## wherein m, a, b, x and y have the meanings indicated in the description.
    Type: Grant
    Filed: July 30, 1997
    Date of Patent: December 15, 1998
    Assignee: Knoll AG
    Inventors: Joerg Rosenberg, Cynthia Romerdahl, Hans-Heinrich Gruenhagen
  • The production of active substance compositions in the form of a solid solution of the active substance in a polymer matrix, and active substance compositions produced by this process
    Patent number: 5741519
    Abstract: A process for producing active substance compositions in the form of a solid solution of the active substance in a polymer matrix, which comprises melt extrusion of the active substance in nonionic form together with a polymer and a salt.
    Type: Grant
    Filed: November 21, 1996
    Date of Patent: April 21, 1998
    Assignee: BASF Aktiengesellschaft
    Inventors: Joerg Rosenberg, Jorg Breitenbach
  • Preparation of colloidal aqueous solutions of active substances of low solubility and a lipid therefor
    Patent number: 5720973
    Abstract: A process for producing solutions of active substances of low solubility, which comprises (1) dissolving the active substance with a phospholipid and a water-soluble lipid in an organic solvent, (2) evaporating the resulting solution to dryness, (3) taking up the residue in a strongly acidic buffer and stirring at elevated temperature until a colloidal solution is produced, (4) cooling the colloidal solution and adjusting to a pH of 6-7 and sterilizing. Particularly suitable for the process are lipids of the formula ##STR1## wherein m, a, b, x and y have the meanings indicated in the description.
    Type: Grant
    Filed: July 19, 1995
    Date of Patent: February 24, 1998
    Assignee: Knoll Aktiengesellschaft
    Inventors: Joerg Rosenberg, Cynthia Romerdahl, Hans-Heinrich Gruenhagen
  • Compositions in the form of solid solutions
    Patent number: 5684040
    Abstract: Compositions in the form of solid solutions containinga) 1-90% by weight of a coumarin derivative A from the group of alkoxycoumarins with a heterocyclic substituent or of hydroxycoumarins esterified with a sulfonic acid as active substance andb) 10-99% by weight of at least one water-soluble polymer B as carrier substance.
    Type: Grant
    Filed: November 7, 1995
    Date of Patent: November 4, 1997
    Assignee: BASF Aktiengesellschaft
    Inventors: Sven Grabowski, Winfried Mueller, Joerg Rosenberg, Rudolf Binder, Axel Sanner