Patents by Inventor Joerg Ruschel

Joerg Ruschel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
    Patent number: 11814361
    Abstract: BA-1049 (R) and its active metabolite are disclosed. Also disclosed are pharmaceutical formulations containing BA-1049 (R) or its active metabolite.
    Type: Grant
    Filed: July 21, 2021
    Date of Patent: November 14, 2023
    Assignee: BioAxone BioSciences, Inc.
    Inventors: Kenneth M. Rosen, Matthew D. Abbinanti, Joerg Ruschel, Lisa McKerracher, Lisa Bond Moritz
  • TREATMENT OF CNS INJURY WITH RNAi THERAPEUTICS
    Publication number: 20220127617
    Abstract: Self-delivering PTEN RNA and methods of reducing PTEN expression are provided herein. Also provided are methods of treating spinal cord injury (SCI) and other neurotrauma with PTEN sdRNA.
    Type: Application
    Filed: July 20, 2021
    Publication date: April 28, 2022
    Inventors: Joerg RUSCHEL, Lisa MCKERRACHER, Emily NIEDERST, Kenneth M. ROSEN
  • RHO KINASE INHIBITOR BA-1049 (R) AND ACTIVE METABOLITES THEREOF
    Publication number: 20220089567
    Abstract: BA-1049 (R) and its active metabolite are disclosed. Also disclosed are pharmaceutical formulations containing BA-1049 (R) or its active metabolite.
    Type: Application
    Filed: July 21, 2021
    Publication date: March 24, 2022
    Applicant: BioAxone BioSciences, Inc.
    Inventors: Kenneth M. ROSEN, Matthew D. ABBINANTI, Joerg RUSCHEL, Lisa MCKERRACHER, Lisa BOND MORITZ
  • Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
    Patent number: 11198680
    Abstract: BA-1049 (R) and its active metabolite are disclosed. Also disclosed are pharmaceutical formulations containing BA-1049 (R) or its active metabolite.
    Type: Grant
    Filed: January 6, 2020
    Date of Patent: December 14, 2021
    Assignee: BioAxone BioSciences, Inc.
    Inventors: Kenneth M. Rosen, Matthew D. Abbinanti, Joerg Ruschel, Lisa McKerracher, Lisa Bond Moritz
  • Treatment of CNS injury with RNAi therapeutics
    Patent number: 11098308
    Abstract: Self-delivering PTEN RNA and methods of reducing PTEN expression are provided herein. Also provided are methods of treating spinal cord injury (SCI) and other neurotrauma with PTEN sdRNA.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: August 24, 2021
    Assignee: BioAxone BioSciences, Inc.
    Inventors: Joerg Ruschel, Lisa McKerracher, Emily Niederst, Kenneth M. Rosen
  • RHO KINASE INHIBITOR BA-1049 (R) AND ACTIVE METABOLITES THEREOF
    Publication number: 20200199105
    Abstract: BA-1049 (R) and its active metabolite are disclosed. Also disclosed are pharmaceutical formulations containing BA-1049 (R) or its active metabolite.
    Type: Application
    Filed: January 6, 2020
    Publication date: June 25, 2020
    Inventors: Kenneth M. ROSEN, Matthew D. ABBINANTI, Joerg RUSCHEL, Lisa MCKERRACHER, Lisa BOND MORITZ
  • TREATMENT OF CNS INJURY WITH RNAi THERAPEUTICS
    Publication number: 20200032268
    Abstract: Self-delivering PTEN RNA and methods of reducing PTEN expression are provided herein. Also provided are methods of treating spinal cord injury (SCI) and other neurotrauma with PTEN sdRNA.
    Type: Application
    Filed: July 27, 2017
    Publication date: January 30, 2020
    Inventors: Joerg RUSCHEL, Lisa MCKERRACHER, Emily NIEDERST, Kenneth M. ROSEN
  • Kinase inhibitors for treatment of disease
    Patent number: 10537567
    Abstract: Disclosed are therapeutic compositions including BA-1076 and/or BA-2057, methods of their use in the treatment of ophthalmological disorders. The therapeutic compositions may further include an IOP-lowering prostaglandin. The methods may further include administration of an IOP-lowering prostaglandin.
    Type: Grant
    Filed: July 11, 2018
    Date of Patent: January 21, 2020
    Assignee: BioAxone BioSciences, Inc.
    Inventors: Joerg Ruschel, Matthew D. Abbinanti, Kenneth M. Rosen, Lisa McKerracher
  • Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
    Patent number: 10526313
    Abstract: BA-1049 (R) and its active metabolite are disclosed. Also disclosed are pharmaceutical formulations containing BA-1049 (R) or its active metabolite.
    Type: Grant
    Filed: May 24, 2018
    Date of Patent: January 7, 2020
    Assignee: BioAxone BioSciences, Inc.
    Inventors: Kenneth M. Rosen, Matthew D. Abbinanti, Joerg Ruschel, Lisa Mckerracher, Lisa Bond Moritz
  • KINASE INHIBITORS FOR TREATMENT OF DISEASE
    Publication number: 20190015404
    Abstract: Disclosed are therapeutic compositions including BA-1076 and/or BA-2057, methods of their use in the treatment of ophthalmological disorders. The therapeutic compositions may further include an IOP-lowering prostaglandin. The methods may further include administration of an IOP-lowering prostaglandin.
    Type: Application
    Filed: July 11, 2018
    Publication date: January 17, 2019
    Inventors: Joerg RUSCHEL, Matthew D. ABBINANTI, Kenneth M. ROSEN, Lisa MCKERRACHER
  • Rho kinase inhibitor BA-1049 (R) and active metabolites thereof
    Patent number: 10106525
    Abstract: The disclosure provides rho kinase inhibitor BA-1049(R), an hydroxy metabolite of BA-1049(R), and adipate salts and deuterated forms thereof, useful for treating CNS disorders and injuries.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: October 23, 2018
    Assignee: BioAxone BioSciences, Inc.
    Inventors: Kenneth M. Rosen, Matthew D. Abbinanti, Joerg Ruschel, Lisa Mckerracher, Lisa Bond Moritz
  • RHO KINASE INHIBITOR BA-1049 (R) AND ACTIVE METABOLITES THEREOF
    Publication number: 20180297982
    Abstract: BA-1049 (R) and its active metabolite are disclosed. Also disclosed are pharmaceutical formulations containing BA-1049 (R) or its active metabolite.
    Type: Application
    Filed: May 24, 2018
    Publication date: October 18, 2018
    Inventors: Kenneth M. Rosen, Matthew D. Abbinanti, Joerg Ruschel, Lisa Mckerracher, Lisa Bond Moritz
  • RHO KINASE INHIBITOR BA-1049 (R) AND ACTIVE METABOLITES THEREOF
    Publication number: 20170313680
    Abstract: The disclosure provides rho kinase inhibitor BA-1049(R), an hydroxy metabolite of BA-1049(R), and adipate salts and deuterated forms thereof, useful for treating CNS disorders and injuries.
    Type: Application
    Filed: May 9, 2017
    Publication date: November 2, 2017
    Inventors: Kenneth M. Rosen, Matthew D. Abbinanti, Joerg Ruschel, Lisa McKerracher, Lisa Bond Mortiz