Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: A torsional moment acting on a component in a drive train of an aircraft may be determined using at least one sensor, where the determined torsional moment is used for adjusting at least one adjustable damping element located in or on the component and/or for regulating a torsional stiffness in the torque-conducting component. As a result, the torsional load in the component may be reduced.

Abstract: The present invention relates to bispecific antibodies against ROR1 and CD3, their manufacture and use.

Abstract: An electronic unit for a vehicle, comprising surface elements arranged next to one another with a visible surface side and a surface underside is disclosed. The surface elements are fixed in a housing. The housing has a top side facing the surface underside and an underside, wherein a carrier plate is provided. Each housing on its underside has at least one protruding fixing element for fixing the surface elements to the carrier plate. The carrier plate connects the surface elements together, wherein each fixing element has an index element arranged on the fixing element between the carrier plate and the underside and is releasably connected to the fixing element. The index elements are connected to the carrier plate by substance bonding so each surface element is releasably fixed to the carrier plate, and wherein by the index elements, the surface elements are arranged relative to and level with one another.

Abstract: The present invention relates to bispecific anti-CCL2 antibodies binding to two different epitopes on human CCL2, pharmaceutical compositions thereof, their manufacture, and use as medicaments for the treatment of cancers, inflammatory, autoimmune and ophthalmologic diseases.

Abstract: A riser sleeve (1) for using when pouring metals into a casting mould includes a riser body (2). The riser body (2) includes a riser cavity (3) for holding liquid metal and a riser opening (4) for joining the riser cavity (3) to a mould cavity of the casting mould during the casting process. The riser cavity (3) has a greater diameter than the diameter of the riser opening (4) in at least one portion, the riser body (2) is made of an insulating and/or exothermic riser material. The riser body (2) is formed as a single piece, the riser opening (4) defines an axis (5), and the riser cavity (3) is asymmetric to the axis (5).

Abstract: In a method of manufacturing a filter feeder intended for insertion into a casting mold used for casting metals, the filter feeder has a feeder body comprising an inner feeder volume, consisting of an exothermic and/or insulating material, with a lateral wall region and with a bottom region comprising a feeder opening for connecting the feeder volume to a casting cavity. A filter element is fixed in the feeder body of the filter feeder. The invention also concerns a device suitable for carrying out the process.

Abstract: A holding adapter for fixing control and signaling devices, including pushbuttons, on a front plate, includes: a housing having a first recess; and a mounting plate mounted in the housing and having a second recess. The second recess is arranged flush with the first recess so that a control or signaling device is guidable in an axial direction through the two recesses. The mounting plate is displaceable in the axial direction relative to the housing between a first end position and a second end position so as to provide a vertical compensation when the control or signaling device is fixed to the front plate, depending upon a thickness of the front plate.

Abstract: The present invention relates to a riser sleeve (1) for using when pouring metals into a casting mould, comprising a riser body (2), comprising a riser cavity (3) for holding liquid metal and a riser opening (4) for joining the riser cavity (3) to a mould cavity of the casting mould during the casting process, wherein the riser cavity (3) has a greater diameter than the diameter of the riser opening (4) in at least one portion, the riser body (2) is made of an insulating and/or exothermic riser material, the riser body (2) is formed as a single piece, the riser opening (4) defines an axis (5), and the riser cavity (3) is asymmetric to the axis (5).

Abstract: A method for producing a feeder (10) that is intended for use in a casting mold used for the casting of metals and comprises a feeder body (11), which encloses an inner cavity (25) as a feeder volume, consists of an exothermic and/or insulating material, has at least one lateral wall region (12) and a bottom region (13) with a feeder opening (14) arranged therein for connecting the inner cavity (25) of the feeder body (11) to the mold cavity of the casting mold during the casting operation and has a mesh-like fabric consisting of a refractory material covering over the feeder opening (14) therein, is characterized in that, in the course of the production of the feeder in a core shooter, a piece of fabric (21) of the mesh-like fabric is positioned in a pattern device (17) forming the shape of the feeder (10) in a core box (30) of the core shooter, in such a way that the peripheral region (22) of the piece of fabric (21) positioned in the bottom region (13) of the later feeder (10) is at least partially bent up

Abstract: In a method for producing a riser for inserting into a casting mold used for casting metals, the riser includes a riser body (31) surrounding an inner cavity (36) as a riser volume and is composed of an exothermic and/or insulating riser material (30). To produce a single-piece riser body (31) in a two-part core box (10), a cavity (14) reproducing the outer contour of the riser body (31) is formed and, in order to produce the inner cavity (36), a reversibly expandable king (15) is set in the cavity (14) in such a way that, in the shooting of the riser body (31), the wall region (32), the cup region (33), and the base region (34) of the riser body are formed by the riser material (30) introduced into the intermediate space (41) between the expanded king (15) and the inner wall (40) of the cavity (14).

Abstract: A holding adapter for fixing control and signaling devices, including pushbuttons, on a front plate, includes: a housing having a first recess; and a mounting plate mounted in the housing and having a second recess. The second recess is arranged flush with the first recess so that a control or signaling device is guidable in an axial direction through the two recesses. The mounting plate is displaceable in the axial direction relative to the housing between a first end position and a second end position so as to provide a vertical compensation when the control or signaling device is fixed to the front plate, depending upon a thickness of the front plate.

Abstract: A method for producing a feeder (10) that is intended for use in a casting mold used for the casting of metals and comprises a feeder body (11), which encloses an inner cavity (25) as a feeder volume, consists of an exothermic and/or insulating material, has at least one lateral wall region (12) and a bottom region (13) with a feeder opening (14) arranged therein for connecting the inner cavity (25) of the feeder body (11) to the mold cavity of the casting mold during the casting operation and has a mesh-like fabric consisting of a refractory material covering over the feeder opening (14) therein, is characterized in that, in the course of the production of the feeder in a core shooter, a piece of fabric (21) of the mesh-like fabric is positioned in a pattern device (17) forming the shape of the feeder (10) in a core box (30) of the core shooter, in such a way that the peripheral region (22) of the piece of fabric (21) positioned in the bottom region (13) of the later feeder (10) is at least partially bent up

Abstract: In a method for producing a riser for inserting into a casting mold used for casting metals, the riser includes a riser body (31) surrounding an inner cavity (36) as a riser volume and is composed of an exothermic and/or insulating riser material (30). To produce a single-piece riser body (31) in a two-part core box (10), a cavity (14) reproducing the outer contour of the riser body (31) is formed and, in order to produce the inner cavity (36), a reversibly expandable king (15) is set in the cavity (14) in such a way that, in the shooting of the riser body (31), the wall region (32), the cup region (33), and the base region (34) of the riser body are formed by the riser material (30) introduced into the intermediate space (41) between the expanded king (15) and the inner wall (40) of the cavity (14).

Abstract: A casting flow running system (11) for supplying liquid metal to a mold cavity formed in a casting mold includes a plurality of pipe sections (13) that are connected to one another; at least one ingate pipe (13) for connecting the casting flow runner system (11) with an ingate of a casting model forming the mold cavity; and a frame (15) made of a heat-resistant material disposed on the ingate pipe (13). The frame has a net-like webbing (18) made of a fireproof material tensioned therein and is attached to the ingate pipe (13) such that the netlike webbing (18) at least partially spans a cross section of the ingate pipe (13) and is positioned in a region proximate to a surface of a casting piece formed by filling the mold cavity.

Abstract: A feeder (10) for use in a casting mold includes a feeder body (11) made from an exothermic and/or insulating material. The feeder body has a bottom surface (15) with a feeder opening (16) for connection of the inner cavity (12) of the feeder body (1) with the mold cavity of the casting mold during a casting process. A ring-shaped frame (17) made of a heat-resistant material is secured to the feeder body (11). A netlike webbing (18) made from a fire-resistant material is tensioned within the ring-shaped frame (17). The frame (17) is arranged on the surface (15) of the feeder body (11), such that the netlike webbing (18) is positioned with the feeder (10) formed in the casting mold directly on a surface of a casting piece to be formed during casting.

Abstract: A breaker core for use in a casting process includes a disk-shaped breaker core (10) having breaker core body and a through-opening (11) for liquid metal. A ring-shaped frame (12) made from a heat-resistant material is secured to the breaker core (10) and has a netlike webbing (15) tensioned therein. The netlike webbing (15) is made from a fire-proof material and spans the through-opening (11) of the breaker core (10) on an underside of a feeder. The frame (17) is secured with an outer sidewall (17) to the body of the disk-shaped breaker core (10). A plane of the netlike webbing (15) tensioned in the frame (12) is secured with a stepped offset to an upper end of the sidewall (17) facing the feeder, so that the netlike webbing (15) is placed in an area of an underside of the breaker core (10) facing the casting model.

Abstract: A casting flow running system (11) for supplying liquid metal to a mold cavity formed in a casting mold includes a plurality of pipe sections (13) that are connected to one another; at least one ingate pipe (13) for connecting the casting flow runner system (11) with an ingate of a casting model forming the mold cavity; and a frame (15) made of a heat-resistant material disposed on the ingate pipe (13). The frame has a net-like webbing (18) made of a fireproof material tensioned therein and is attached to the ingate pipe (13) such that the netlike webbing (18) at least partially spans a cross section of the ingate pipe (13) and is positioned in a region proximate to a surface of a casting piece formed by filling the mold cavity.

Abstract: A feeder (10) for use in a casting mold includes a feeder body (11) made from an exothermic and/or insulating material. The feeder body has a bottom surface (15) with a feeder opening (16) for connection of the inner cavity (12) of the feeder body (1) with the mold cavity of the casting mold during a casting process. A ring-shaped frame (17) made of a heat-resistant material is secured to the feeder body (11). A netlike webbing (18) made from a fire-resistant material is tensioned within the ring-shaped frame (17). The frame (17) is arranged on the surface (15) of the feeder body (11), such that the netlike webbing (18) is positioned with the feeder (10) formed in the casting mold directly on a surface of a casting piece to be formed during casting.

Abstract: A breaker core for use in a casting process includes a disk-shaped breaker core (10) having breaker core body and a through-opening (11) for liquid metal. A ring-shaped frame (12) made from a heat-resistant material is secured to the breaker core (10) and has a netlike webbing (15) tensioned therein. The netlike webbing (15) is made from a fire-proof material and spans the through-opening (11) of the breaker core (10) on an underside of a feeder. The frame (17) is secured with an outer sidewall (17) to the body of the disk-shaped breaker core (10). A plane of the netlike webbing (15) tensioned in the frame (12) is secured with a stepped offset to an upper end of the sidewall (17) facing the feeder, so that the netlike webbing (15) is placed in an area of an underside of the breaker core (10) facing the casting model.