Patents by Inventor Joerg Schiewe
Joerg Schiewe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8496944Abstract: The invention relates to an improved process for the production of powders of an inhalable medicament by crystallization from a supersaturated fluid containing said medicament, the method comprising passing along a tubular reactor (a) a segmented flow of that fluid comprised of discrete volumes; or (b) a fluid mixture being separated by discrete volumes of a separating fluid which is substantially immiscible with said fluid, characterized in that the crystallization is initiated by application of ultrasound.Type: GrantFiled: November 3, 2008Date of Patent: July 30, 2013Assignees: Boehringer Ingelheim Pharma Gmbh Co. KG, Ingelheim am Rhein, Germany and Ecole Polytechnique Federale de LausanneInventors: Nathalie Jongen, Jacques LemaƮtre, Paul Bowen, Marcel Donnet, Joerg Schiewe, Bernd Zierenberg, Cristina Lucica Soare
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Publication number: 20120034275Abstract: The present invention relates to powder formulations for inhalation containing enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3 and R4 may have the meanings given in the claims and in the specification, optionally in the form of the pharmaceutically acceptable acid addition salts thereof, as well as optionally in combination with a pharmaceutically acceptable excipient, processes for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.Type: ApplicationFiled: June 7, 2011Publication date: February 9, 2012Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Michael Josef Friedrich TRUNK, Joerg SCHIEWE
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Publication number: 20110203586Abstract: The invention relates to a powder inhaler for administering moisture-sensitive pharmaceutical formulations.Type: ApplicationFiled: February 20, 2008Publication date: August 25, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Marc Egen, Michael Krueger, Joerg Schiewe
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Patent number: 7984713Abstract: The invention relates to a powder inhaler (1) with mouthpiece (2) for dispersing pharmaceutical medicament formulations, which comprises an auxiliary energy source in the form of a pressure medium system (3), having a device for supplying (6) a powder formulation (7), while on activation of the pressure medium system a gaseous pressure medium (8) released by the pressure medium system (3) forms an aerosol (9) with the powder formulation (7) such that the powder particles are present in the gaseous pressure medium (8) in dispersed form. This is achieved by means of a powder inhaler (1) comprising a multi-channel nozzle, the channels of which are inclined to one another at an angle such that the aerosol jets flowing through them meet one another downstream behind the nozzle (10).Type: GrantFiled: March 4, 2005Date of Patent: July 26, 2011Assignee: Boehringer Ingelheim International GmbHInventors: Dieter Hochrainer, Stephen Terence Dunne, Georg Boeck, Joerg Schiewe
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Publication number: 20110061652Abstract: The invention relates to a blister for charging an inhaler with a pharmaceutical preparation, characterised in that the blister is at least partially manufactured from a dehydrating plastics material. The invention also relates to blisters according to the invention which are filled with a pharmaceutical preparation.Type: ApplicationFiled: November 18, 2010Publication date: March 17, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Michael KRUEGER, Burkhard METZGER, Michael TRUNK, Joerg SCHIEWE
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Patent number: 7708011Abstract: A dry powder inhaler (1) is to be made available, with which a particle size and particle size distribution preferred for inhalation are to be achieved and by means of which as high a line particle fraction as possible is to be realized. This is achieved by means of a dry powder inhaler (1 ) that is characterized in that provided in the inhaler (1) is a nozzle (10) through which the aerosol (9) flows before leaving the inhaler (1).Type: GrantFiled: September 24, 2003Date of Patent: May 4, 2010Assignee: Boehringer Ingelheim Pharma GmbH and Co. KGInventors: Dieter Hochrainer, Joerg Schiewe, Bernd Zierenberg, Stephen Dunne
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Publication number: 20100096408Abstract: The present invention relates to a propellant-gas-free apparatus for the dispensing of liquids, a container cartridge suitable for this for storing the liquid and the ensemble comprising both. The invention comprises a device for the exertion of pressure and for accommodating a container cartridge and a container cartridge in which the dispensing facility is integrated.Type: ApplicationFiled: December 22, 2009Publication date: April 22, 2010Applicant: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Joerg Schiewe, Gilbert Wuttke, Bernd Zierenberg, Stephen Dunne, Horst Wergen
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Patent number: 7699052Abstract: The present invention relates to a propellant-gas-free apparatus for the dispensing of liquids, a container cartridge suitable for this for storing the liquid and the ensemble comprising both. The invention comprises a device for the exertion of pressure and for accommodating a container cartridge and a container cartridge in which the dispensing facility is integrated.Type: GrantFiled: August 26, 2003Date of Patent: April 20, 2010Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Joerg Schiewe, Gilbert Wuttke, Bernd Zierenberg, Stephen Dunne, Horst Wergen
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Publication number: 20090235929Abstract: The invention relates to a powder inhaler for administering moisture-sensitive pharmaceutical formulations.Type: ApplicationFiled: March 19, 2008Publication date: September 24, 2009Inventors: Marc EGEN, Michael Krueger, Joerg Schiewe
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Publication number: 20090068275Abstract: The invention relates to an improved process for the production of powders of an inhalable medicament by crystallization from a supersaturated fluid containing said medicament, the method comprising passing along a tubular reactor (a) a segmented flow of that fluid comprised of discrete volumes; or (b) a fluid mixture being separated by discrete volumes of a separating fluid which is substantially immiscible with said fluid, characterized in that the crystallization is initiated by application of ultrasoundType: ApplicationFiled: November 3, 2008Publication date: March 12, 2009Applicants: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE, Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Nathalie JONGEN, Jacques LEMAITRE, Paul BOWEN, Marcel DONNET, Joerg SCHIEWE, Bernd ZIERENBERG
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Patent number: 7249599Abstract: A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exists from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch.Type: GrantFiled: June 30, 2005Date of Patent: July 31, 2007Assignee: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Joerg Schiewe, Bernd Zierenberg
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Patent number: 7066171Abstract: A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exits from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch.Type: GrantFiled: May 19, 2003Date of Patent: June 27, 2006Assignee: Boehringer Ingelheim Pharma KGInventors: Joerg Schiewe, Bernd Zierenberg
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Publication number: 20060134007Abstract: The invention relates to a blister for charging an inhaler with a pharmaceutical preparation, characterised in that the blister is at least partially manufactured from a dehydrating plastics material. The invention also relates to blisters according to the invention which are filled with a pharmaceutical preparation.Type: ApplicationFiled: October 19, 2005Publication date: June 22, 2006Applicant: Boehringer Ingelheim International GmbHInventors: Michael Krueger, Burkhard Metzger, Michael Trunk, Joerg Schiewe
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Publication number: 20050263151Abstract: The invention relates to a powder inhaler (1) with mouthpiece (2) for dispersing pharmaceutical medicament formulations, which comprises an auxiliary energy source in the form of a pressure medium system (3), having a device for supplying (6) a powder formulation (7), while on activation of the pressure medium system a gaseous pressure medium (8) released by the pressure medium system (3) forms an aerosol (9) with the powder formulation (7) such that the powder particles are present in the gaseous pressure medium (8) in dispersed form. This is achieved by means of a powder inhaler (1) comprising a multi-channel nozzle, the channels of which are inclined to one another at an angle such that the aerosol jets flowing through them meet one another downstream behind the nozzle (10).Type: ApplicationFiled: March 4, 2005Publication date: December 1, 2005Applicant: Boehringer Ingelheim International GmbHInventors: Dieter Hochrainer, Stephen Dunne, Georg Boeck, Joerg Schiewe
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Publication number: 20050255050Abstract: The present invention relates to powder formulations for inhalation containing enantiomerically pure compounds of general formula 1 wherein the groups R1, R2, R3 and R4 may have the meanings given in the claims and in the specification, optionally in the form of the pharmaceutically acceptable acid addition salts thereof, as well as optionally in combination with a pharmaceutically acceptable excipient, processes for preparing them and their use as pharmaceutical compositions, particularly as pharmaceutical compositions for the treatment of respiratory complaints.Type: ApplicationFiled: May 12, 2005Publication date: November 17, 2005Applicant: Boehringer Ingelheim International GmbHInventors: Michael Trunk, Joerg Schiewe
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Publication number: 20050244314Abstract: A method for crystallizing a substance, especially an inhalable medicament, comprising the following steps: (a) dissolving said substance in a solvent, to produce a solution of said substance, (b) producing a segmented stream which consists of alternating segments of said solution of the substance and of a transport medium, (c) introducing said segmented stream into the first end of a retention stretch, which retention stretch has a first end and a second end, so that said segmented stream passes from said first end to said second end of said retention stretch, and exists from the second end of the retention stretch, (d) cooling the retention stretch, to thereby bring about crystallization of the substance in the segments of solution, in the segmented stream, as said segmented stream passes through the retention stretch, and (e) separating the crystals of material from the segmented stream as it exits from the second end of the retention stretch. Also disclosed is an apparatus for carrying out the method.Type: ApplicationFiled: June 30, 2005Publication date: November 3, 2005Applicant: Boehringer Ingelheim Pharma KGInventors: Joerg Schiewe, Bernd Zierenberg
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Publication number: 20040197275Abstract: The invention relates to an improved process for the production of powders of an inhalable medicament by crystallization from a supersaturated fluid containing said medicament, the method comprising passing along a tubular reactorType: ApplicationFiled: October 14, 2003Publication date: October 7, 2004Applicants: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE, Boehringer Ingelheim Pharma GmbH & Co., KGInventors: Nathalie Jongen, Jacques Lemaitre, Paul Bowen, Marcel Donnet, Joerg Schiewe, Bernd Zierenberg, Cristina Lucica Soare
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Publication number: 20040187868Abstract: The invention pertains to a dry powder inhaler (1) with a mouthpiece (2) for dispersing pharmaceutical drug formulations, which has available an auxiliary energy source in the form of a pressure medium system (3), with a device for provisioning (6) of a powder formulation (7), whereby upon activation of the pressure medium system a gaseous pressure medium (8) released by the pressure medium system (3) forms with the powder formulation (7) an aerosol (9) in such a way that the powder particles are present in dispersed form within the gaseous pressure medium (8).Type: ApplicationFiled: September 24, 2003Publication date: September 30, 2004Applicant: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Dieter Hochrainer, Joerg Schiewe, Bernd Zierenberg, Stephen Dunne
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Publication number: 20040173211Abstract: The invention relates to powder inhalers in which at least part of the inner surface coming into contact with the powder aerosol is microstructured. Preferably, it is a powder inhaler operating on the Bernoulli principle (a Bernoulli inhaler).Type: ApplicationFiled: January 14, 2004Publication date: September 9, 2004Applicant: Boehringer Ingelheim International GmbHInventors: Heinrich Kladders, Joerg Schiewe
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Publication number: 20040094146Abstract: The present invention relates to a propellant-gas-free apparatus for the dispensing of liquids, a container cartridge suitable for this for storing the liquid and the ensemble comprising both. The invention comprises a device for the exertion of pressure and for accommodating a container cartridge and a container cartridge in which the dispensing facility is integrated.Type: ApplicationFiled: August 26, 2003Publication date: May 20, 2004Applicant: Boehringer Ingelheim Pharma GmbH & Co. KGInventors: Joerg Schiewe, Gilbert Wuttke, Bernd Zierenberg, Stephen Dunne, Horst Wergen