Patents by Inventor Joeri Johannes Petrus DE WIT

Joeri Johannes Petrus DE WIT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 3-hydroxy-imidazolidin-4-one compounds as inhibitors of indoleamine 2,3-dioxygenase
    Patent number: 11053230
    Abstract: The invention relates to a compound of Formula (I): Formula (I), or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: July 6, 2021
    Inventors: Adrianus Petrus Antonius De Man, Joost Cornelis Marinus Uitdehaag, Jan Gerard Sterrenburg, Joeri Johannes Petrus De Wit, Freek Van Cauter, Nicole Wilhelmina Cornelia Seegers, Antonius Maria Van Doornmalen, Rogier Christian Buijsman, Guido Jenny Rudolf Zaman
  • Inhibitors of tryptophan 2,3-dioxygenase
    Patent number: 10689343
    Abstract: The invention relates to a compound of Formula I: Formula I, or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of tryptophan 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of cancer and central nervous system disease or disorder, either as a single agent or in combination with other therapies.
    Type: Grant
    Filed: July 11, 2017
    Date of Patent: June 23, 2020
    Assignee: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    Inventors: Adrianus Petrus Antonius De Man, Joost Cornelis Marinus Uitdehaag, Jan Gerard Sterrenburg, Joeri Johannes Petrus De Wit, Nicole Wilhelmina Cornelia Seegers, Antonius Maria Van Doornmalen, Rogier Christian Buijsman, Guido Jenny Rudolf Zaman
  • 3-HYDROXY-IMIDAZOLIDIN-4-ONE COMPOUNDS AS INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE
    Publication number: 20200181128
    Abstract: The invention relates to a compound of Formula (I): Formula (I), or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.
    Type: Application
    Filed: August 30, 2018
    Publication date: June 11, 2020
    Applicant: Netherlands Translational Research Center B.V.
    Inventors: Adrianus Petrus Antonius De Man, Joost Cornelis Marinus Uitdehaag, Jan Gerard Sterrenburg, Joeri Johannes Petrus De Wit, Freek Van Cauter, Nicole Wilhelmina Cornelia Seegers, Antonius Maria Van Doornmalen, Rogier Christian Buijsman, Guido Jenny Rudolf Zaman
  • Inhibitors of indoleamine 2,3-dioxygenase
    Patent number: 10494360
    Abstract: A compound of Formula I: or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.
    Type: Grant
    Filed: March 8, 2017
    Date of Patent: December 3, 2019
    Assignee: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V
    Inventors: Adrianus Petrus Antonius De Man, Joost Cornelis Marinus Uitdehaag, Jan Gerard Sterrenburg, Joeri Johannes Petrus De Wit, Nicole Wilhelmina Cornelia Seegers, Antonius Maria Van Doornmalen, Rogier Christian Buijsman, Guido Jenny Rudolf Zaman
  • INTIBTORS OF TRYPTOPHAN 2,3-DIOXYGENASE
    Publication number: 20190315688
    Abstract: The invention relates to a compound of Formula I: Formula I, or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of tryptophan 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of cancer and central nervous system disease or disorder, either as a single agent or in combination with other therapies.
    Type: Application
    Filed: July 11, 2017
    Publication date: October 17, 2019
    Applicant: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    Inventors: Adrianus Petrus Antonius De Man, Joost Cornelis Marinus Uitdehaag, Jan Gerard Sterrenburg, Joeri Johannes Petrus De Wit, Nicole Wilhelmina Cornelia Seegers, Antonius Maria Van Doornmalen, Rogier Christian Buijsman, Guido Jenny Rudolf Zaman
  • INHIBITORS OF INDOLEAMINE 2,3-DIOXYGENASE
    Publication number: 20190055213
    Abstract: A compound of Formula I: or pharmaceutically acceptable enantiomers, or salts thereof. The present invention also relates to the use of compounds of Formula (I) as selective inhibitors of indoleamine 2,3-dioxygenase. The invention also relates to the use of the compounds of Formula (I) for the treatment or prevention of diseases cancer, infections, central nervous system disease or disorder, and immune-related disorders, either as a single agent or in combination with other therapies.
    Type: Application
    Filed: March 8, 2017
    Publication date: February 21, 2019
    Applicant: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    Inventors: Adrianus Petrus Antonius DE MAN, Joost Cornelis Marinus UITDEHAAG, Jan Gerard STERRENBURG, Joeri Johannes Petrus DE WIT, Nicole Wilhelmina Cornelia SEEGERS, Antonius Maria VAN DOORNMALEN, Rogier Christian BUIJSMAN, Guido Jenny Rudolf ZAMAN
  • (5,6-dihydro)pyrimido[4,5-E]indolizines
    Patent number: 9856258
    Abstract: A compound of Formula I: wherein, R1 and R2 independently are selected from the group consisting of optionally substituted (6-10C)aryl and (1-5C)heteroaryl groups. The compounds can be used in pharmaceutical compositions, in particular in the treatment of cancer.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: January 2, 2018
    Assignee: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    Inventors: Adrianus Petrus Antonius De Man, Rogier Christian Buijsman, Jan Gerard Sterrenburg, Joost Cornelis Marinus Uitdehaag, Joeri Johannes Petrus De Wit, Guido Jenny Rudolf Zaman
  • (5,6-DIHYDRO)PYRIMIDO[4,5-E]INDOLIZINES
    Publication number: 20170096432
    Abstract: A compound of Formula I: wherein, R1 and R2 independently are selected from the group consisting of optionally substituted (6-10C)aryl and (1-5C)heteroaryl groups. The compounds can be used in pharmaceutical compositions, in particular in the treatment of cancer.
    Type: Application
    Filed: March 30, 2015
    Publication date: April 6, 2017
    Applicant: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    Inventors: Adrianus Petrus Antonius DE MAN, Rogier Christian BUIJSMAN, Jan Gerard STERRENBURG, Joost Cornelis Marinus UITDEHAAG, Joeri Johannes Petrus DE WIT, Guido Jenny Rudolf ZAMAN
  • (5,6-dihydro)pyrimido[4,5-E]indolizines
    Patent number: RE48974
    Abstract: A compound of Formula I: wherein, R1 and R2 independently are selected from the group consisting of optionally substituted (6-10C)aryl and (1-5C)heteroaryl groups. The compounds can be used in pharmaceutical compositions, in particular in the treatment of cancer.
    Type: Grant
    Filed: December 27, 2019
    Date of Patent: March 15, 2022
    Assignee: NETHERLANDS TRANSLATIONAL RESEARCH CENTER B.V.
    Inventors: Adrianus Petrus Antonius De Man, Rogier Christian Buijsman, Jan Gerard Sterrenburg, Joost Cornelis Marinus Uitdehaag, Joeri Johannes Petrus De Wit, Guido Jenny Rudolf Zaman