Patents by Inventor Joerk Zwicker

Joerk Zwicker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid construct for the cell cycle regulated expression of structural genes
    Patent number: 6380170
    Abstract: The invention refers to a nucleic acid construct comprising at least one activator sequence, at least one chimeric promoter module comprising a nucleotide sequence which binds a protein of the E2F family and a protein of the CDF-1 family, and at least one gene, wherein said chimeric promoter module promotes expression of the gene in the cell cycle later than the B-myb promoter but earlier than the cdc25C promoter. The invention also concerns the purification and identification of CDF-1 protein, and use of this protein to develop new control systems.
    Type: Grant
    Filed: February 18, 1998
    Date of Patent: April 30, 2002
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Rolf Müller, Ningshu Liu, Jörk Zwicker, Hans-Harald Sedlacek
  • Nucleic acid constructs for the cell cycle-regulated expression of genes and therapeutic methods utilizing such constructs
    Patent number: 5885833
    Abstract: Nucleic acid constructs comprising an activator sequence, a promoter module, and a structural gene are disclosed. The promoter module comprises a a CHR region and a nucleic acid sequence that binds a protein of the E2F family. These constructs are used in gene therapy, such as the treatment of disorders characterized by excess cell proliferation.
    Type: Grant
    Filed: February 13, 1997
    Date of Patent: March 23, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rolf Mueller, Joerk Zwicker, Hans-Harald Sedlacek