Patents by Inventor Johan Aarum

Johan Aarum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for screening anti-protein aggregation agents using single-stranded specific RNAses to initiate protein aggregation
    Patent number: 9863954
    Abstract: The present invention provides the use of RNA removal to initiate protein aggregation of a plurality of proteins in a cell or cell lysate. This may be used to create an in vitro model of a disease, such as a neurodegenerative disease. The present invention also provides a method for determining the efficacy of a potential anti-protein aggregation agent comprising the following steps: i) using RNA removal to initiate the aggregation of a protein in a cell or cell lysate, ii) treating the cell or cell lysate with the potential anti-protein aggregation agent before, after or during RNA removal; and iii) comparing protein aggregation in equivalent samples with and without step ii) treatment in which a decrease in protein aggregation associated with step ii) treatment indicates that the potential anti-protein aggregation agent is effective in preventing and/or reversing protein aggregation.
    Type: Grant
    Filed: January 23, 2014
    Date of Patent: January 9, 2018
    Assignee: Queen Mary University of London
    Inventors: Johan Aarum, Denise Schwarz
  • Method for Preventing or Treating a Protein Aggregation Disease
    Publication number: 20170202878
    Abstract: The present invention relates to a method for treating and/or preventing a disease associated with protein aggregation which comprises the step of preventing protein aggregation associated with RNA removal, by stabilising RNA; or reversing protein aggregation associated with RNA removal, by effectively replacing removed RNA.
    Type: Application
    Filed: July 17, 2015
    Publication date: July 20, 2017
    Inventors: Denise Schwarz, Johan Aarum
  • USE OF RNA REMOVAL TO INITIATE PROTEIN AGGREGATION
    Publication number: 20150369814
    Abstract: The present invention provides the use of RNA removal to initiate protein aggregation of a plurality of proteins in a cell or cell lysate. This may be used to create an in vitro model of a disease, such as a neurodegenerative disease. The present invention also provides a method for determining the efficacy of a potential anti-protein aggregation agent comprising the following steps: i) using RNA removal to initiate the aggregation of a protein in a cell or cell lysate, ii) treating the cell or cell lysate with the potential anti-protein aggregation agent before, after or during RNA removal; and iii) comparing protein aggregation in equivalent samples with and without step ii) treatment in which a decrease in protein aggregation associated with step ii) treatment indicates that the potential anti-protein aggregation agent is effective in preventing and/or reversing protein aggregation.
    Type: Application
    Filed: January 23, 2014
    Publication date: December 24, 2015
    Inventors: Johan Aarum, Denise Sheer