Abstract: A remote-control unit (10) is adapted for sending a control signal with instructions as an acoustic signal for controlling a hearing assistive device (20). A calibration method comprises outputting tone frequencies applied by the control signal, receiving the output tone frequencies and compare tone frequency levels relatively to a reference, adjusting relative volumes of the tone frequencies applied by the control signal in dependence of the comparison, and storing the adjusted relative volumes of the tone frequencies for use when sending a control signal with instructions as acoustic signals.

Abstract: A remote-control unit (10) is adapted for sending a control signal with instructions as an acoustic signal for controlling a hearing assistive device (20). A calibration method comprises outputting tone frequencies applied by the control signal, receiving the output tone frequencies and compare tone frequency levels relatively to a reference, adjusting relative volumes of the tone frequencies applied by the control signal in dependence of the comparison, and storing the adjusted relative volumes of the tone frequencies for use when sending a control signal with instructions as acoustic signals.

Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).

Abstract: A remote-control unit (10) for controlling a hearing assistive device (20) by sending a control signal with instructions as an acoustic signal, has an input transducer (14), an output transducer (15), and a processor (11) adapted for setting the volume of the output from the output transducer (15). The processor (11) is adapted for activating the input transducer (14) for receiving environmental sound, analyzing the environmental sound, determining and setting the volume of the output from the output transducer (15) based on the environmental sound, and outputting the control signal at the set volume via the output transducer (15).

Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).

Abstract: A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.

Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).

Abstract: A remote-control unit (10) for controlling a hearing assistive device (20) by sending a control signal with instructions as an acoustic signal, has an input transducer (14), an output transducer (15), and a processor (11) adapted for setting the volume of the output from the output transducer (15). The processor (11) is adapted for activating the input transducer (14) for receiving environmental sound, analyzing the environmental sound, determining and setting the volume of the output from the output transducer (15) based on the environmental sound, and outputting the control signal at the set volume via the output transducer (15).

Abstract: The invention discloses novel methods for biosynthesis of forskolin and other oxidised 13R-MOs. Oxidised 13R-MO may be valuable 011 its own account or as precursors for production of forskolin. In particular, the invention provides methods of producing an oxidised 13R-manoyl oxide (13R-MO) comprising the steps of providing a host organism comprising a heterologous nucleic acid encoding an enzyme capable of catalysing hydroxylation of 13R-MO and or oxidised 13R-MO at the 9 position, wherein said oxidised 13R-MO carries a —H at the 9-position and incubating said host organism in the presence of I3R-MO under conditions allowing growth of said host organism. The invention also discloses materials for use in said methods, in particular the invention provides the enzyme CYP76AH16.

Abstract: A method for producing an octaketide derived aromatic compound of interest (e.g. carminic acid), wherein the method comprises (I): heterologous expression of a recombinantly introduced Type III polyketide synthase (PKS) gene encoding an octaketide synthase (OKS) to obtain non-reduced octaketide in vivo within the recombinant host cell and (II): converting in vivo the non-reduced octaketide of step (I) into a C14-C34 aromatic compound of interest (e.g. carminic acid).

Abstract: The invention described materials and methods for producing oxidized 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.

Abstract: The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.

Abstract: A method for producing individual or libraries of tri- to pentadecaketide-derived aromatic compounds of interest by heterologous expression of polyketide synthase and aromatase/cyclase in a recombinant host cell.

Abstract: The invention described materials and methods for producing oxidized 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.

Abstract: The invention relates to recombinant microorganisms and methods for producing acetylated diterpenes, including oxidized and/or acetylated oxidized diterpenes such as forskolin.

Abstract: The present invention discloses that by combining different di TPS enzymes of class I and class II different diterpenes may be produced including diterpenes not identified in nature. Surprisingly it is revealed that a di TPS enzyme of class I of one species may be combined with a di TPS enzyme of class II from a different species, resulting in a high diversity of diterpenes, which can be produced.

Abstract: The invention described materials and methods for producing oxidised 13R-MO, such as forskolin. In particular, the invention describes P450s involved in oxidation of 13R-MO including CYP76AH8, CYP76AH11, CYP76AH15, CYP76AH17, CYP71D381 and CYP76AH9. Host organisms expressing one or more of these P450s are useful in the production of oxidized 13R-MO.

Abstract: The present invention relates to a method for manufacturing enantiomerically pure (13R)-manoyl oxide, said method comprising the steps of contacting geranylgeranyl diphosphate (GGPP) with a class II diterpene synthase to obtain labd-13-en-8,15-diol diphosphate (LPP), and then contacting the LPP with a class I diterpene synthase to obtain (13R)-manoyl oxide. The invention further relates to (13R)-manoyl oxide obtained by the method of the invention.