Abstract: The specification generally relates to compounds of Formula (I), and pharmaceutically acceptable salts thereof, where A, U, V, W, X, Y, Z, R1, R2, R3, R4 and R5 have the meanings defined herein. Such compounds are modulators of RXFP1 and may be useful as therapeutic agents. The specification also relates to the use of such compounds to treat or prevent diseases and conditions including heart failure, heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, heart failure with reduced ejection fraction, chronic kidney disease and acute kidney injury. The specification further relates to compositions comprising such compounds, intermediates useful in processes for preparing such compounds, and processes for preparing such compounds using such intermediates.

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: A bidirectional magnetic clutch for an additive manufacturing system, comprising a concentric arrangement of an inner drive member (2) and an outer drive member (3) enclosing the inner drive member (2), the inner and outer drive members (2,3) being rotatable relative to each other. The inner drive member (2) comprises at least two outward facing recesses (5, 6) and the outer drive member (3) comprises at least two inward facing recesses (8,9). Each outward facing recess (5,6) comprises a radially moveable roller member (10,11) of ferromagnetic material. The inner drive member (2) further comprises a magnetic biasing system (12) configured to magnetically bias the roller members (10,11) into the outward facing recesses (5,6). The bidirectional magnetic clutch further comprises a magnet actuator (13) at least partially circumferentially arranged around the outer drive member (3) and configured to maintain an engaged state or disengaged state of the bidirectional magnetic clutch.

Abstract: A bidirectional magnetic clutch for an additive manufacturing system, comprising a concentric arrangement of an inner drive member (2) and an outer drive member (3) enclosing the inner drive member (2), the inner and outer drive members (2,3) being rotatable relative to each other. The inner drive member (2) comprises at least two outward facing recesses (5, 6) and the outer drive member (3) comprises at least two inward facing recesses (8,9). Each outward facing recess (5,6) comprises a radially moveable roller member (10,11) of ferromagnetic material. The inner drive member (2) further comprises a magnetic biasing system (12) configured to magnetically bias the roller members (10,11) into the outward facing recesses (5,6). The bidirectional magnetic clutch further comprises a magnet actuator (13) at least partially circumferentially arranged around the outer drive member (3) and configured to maintain an engaged state or disengaged state of the bidirectional magnetic clutch.

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The invention is in the field of catalysis. More specifically, the invention relates to a process for preparing a protected metal catalyst on a support; a matrix particle comprising the protected metal catalyst; and, a process for hydrogenating a hydrocarbon resin feedstock using the protected metal catalyst.

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: An inductive nozzle heating assembly for an additive manufacturing system, comprises a rod shaped nozzle body of electrically conductive material provided with a passageway extending from an inlet end to an outlet end of the rod shaped nozzle body for dispensing an extrudable material. An induction coil unit is provided for magnetic engagement with the rod shaped nozzle body to allow heating thereof, wherein the induction coil unit encloses at least in part the rod shaped nozzle body. The induction coil unit and rod shaped nozzle body are spaced apart and separated by a minimum distance (Lg) larger than zero, and the rod shaped nozzle body comprises a heating piece having a predetermined Curie temperature.

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: An additive manufacturing system for building three-dimensional objects, comprising a box-shaped build chamber (2) having a plurality of sides (4), and an x-y gantry (10) having mounted thereon a nozzle head assembly (12) for movement thereof relative to the build chamber (2). The additive manufacturing system (1) further comprises a plurality of roller units (14, 16) evenly arranged along a circumference (18) of one side of the plurality of sides (4), wherein each roller unit (14, 16) comprises a cover sheet (20, 22) rolled at least in part into coil form and wherein each cover sheet (20, 22) extends from the roller unit (14, 16) to the nozzle head assembly (12) for closing the build chamber (2) there between. Each roller unit (14, 16) is configured to allow the cover sheet (20, 22) to coil and uncoil in correspondence to the movement of the nozzle head assembly (12).

Abstract: The invention is in the field of catalysis. More specifically, the invention relates to a process for preparing a protected metal catalyst on a support; a matrix particle comprising the protected metal catalyst; and, a process for hydrogenating a hydrocarbon resin feedstock using the protected metal catalyst.

Abstract: A nozzle for a three-dimensional printing apparatus, comprising a main nozzle body (2) having an inlet end (4), an outlet end (6) and a central conduit (8) arranged there between, wherein the main nozzle body (2) is made of an electrically non-conductive body material. The main nozzle body (2) is provided with an electrically conductive first layer (10) and/or an electrically non-conductive second layer (12) arranged around the main nozzle body (2).

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: The present application relates to novel compounds of formula (I) to their utility in treating and/or preventing clinical conditions including cardiovascular diseases (CVD), to methods for their therapeutic use, to pharmaceutical compositions containing them and to processes for preparing such compounds.

Abstract: A nozzle for a three-dimensional printing apparatus, comprising a main nozzle body (2) having an inlet end (4), an outlet end (6) and a central conduit (8) arranged there between, wherein the main nozzle body (2) is made of an electrically non-conductive body material. The main nozzle body (2) is provided with an electrically conductive first layer (10) and/or an electrically non-conductive second layer (12) arranged around the main nozzle body (2).

Abstract: The invention is in the field of catalysis. More specifically, the invention pertains to catalytic hydrogenation processes and catalysts used therein. According to the invention there is provided a process for the hydrogenation of hydrocarbon resins, in particular hydrocarbon resin feeds with a relatively high sulfur content using a cobalt promoted nickel on silica/alumina catalyst, the catalyst per se, and the process of preparing said catalyst.

Abstract: An inductive nozzle heating assembly for an additive manufacturing system, comprises a rod shaped nozzle body of electrically conductive material provided with a passageway extending from an inlet end to an outlet end of the rod shaped nozzle body for dispensing an extrudable material. An induction coil unit is provided for magnetic engagement with the rod shaped nozzle body to allow heating thereof, wherein the induction coil unit encloses at least in part the rod shaped nozzle body. The induction coil unit and rod shaped nozzle body are spaced apart and separated by a minimum distance (Lg) larger than zero, and the rod shaped nozzle body comprises a heating piece having a predetermined Curie temperature.