Abstract: An implementation of SSP using variable depth for the vectors extending normal to the surface voxels of the brain so as to avoid white matter uptake extraction is provided. The implementation also provides the possibility to compare SSP for an individual amyloid imaging agent image to a SSP normal database and allows for 3D visualization of SSP information.

Abstract: An implementation of SSP using variable depth for the vectors extending normal to the surface voxels of the brain so as to avoid white matter uptake extraction is provided. The implementation also provides the possibility to compare SSP for an individual amyloid imaging agent image to a SSP normal database and allows for 3D visualization of SSP information.

Abstract: A system (100) and method for clinical evaluation of neurodegenerative disease present in a subject is described. The system (100) comprises an image acquisition module (122) operable to acquire image data representative of a brain of a subject, and an image analyser (124). The image analyser (124) is operable to determine a quantitative value from the image data that is indicative of the level of neurodegenerative disease present in the brain of the subject. Various embodiments of the invention provide a tool that aids in improved early diagnosis and monitoring of neurodegenerative diseases, such as, for example, Alzheimer's disease (AD).