Patents by Inventor Johan Fransson

Johan Fransson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Nucleic acid molecules encoding anti-CD27 antibodies
    Patent number: 9683046
    Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
    Type: Grant
    Filed: July 2, 2015
    Date of Patent: June 20, 2017
    Assignee: Janssen Biotech, Inc.
    Inventors: John Chen, Johan Fransson, Natalie Fursov, Damon Hamel, Thomas Malia, Galina Obmolova, Tatiana Ort, Michael Rycyzyn, Michael Scully, Raymond Sweet, Alexey Teplyakov, John Wheeler, Juan Carlos Almagro
  • Agonistic Antibodies Specifically Binding CD40 and Methods of Use
    Publication number: 20170088624
    Abstract: The present invention relates to agonistic antibodies specifically binding human CD40, polynucleotides encoding the antibodies or antigen-binding fragments, and methods of making and using the foregoing.
    Type: Application
    Filed: September 30, 2016
    Publication date: March 30, 2017
    Inventors: Johan Fransson, Paul Kim, Michael Quigley, Andressa Smith, Alexey Teplyakov, Hong Zhou
  • Anti-CD154 antibodies and methods of using them
    Publication number: 20170037136
    Abstract: The present invention relates to antagonistic antibodies specifically binding CD154, polynucleotides encoding the antibodies or fragments, and methods of making and using the foregoing.
    Type: Application
    Filed: August 4, 2016
    Publication date: February 9, 2017
    Inventors: Johan Fransson, Galina Obmolova, Anish Suri, Fang Teng, Alexey Teplyakov, Hong Zhou, Jocelyn Leu
  • Human Anti-CD27 Antibodies, Methods and Uses
    Publication number: 20150299330
    Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
    Type: Application
    Filed: July 2, 2015
    Publication date: October 22, 2015
    Inventors: John Chen, Johan Fransson, Natalie Fursov, Damon Hamel, Thomas Malia, Galina Obmolova, Tatiana Ort, Michael Rycyzyn, Michael Scully, Raymond Sweet, Alexey Teplyakov, John Wheeler, Juan Carlos Almagro
  • Human oncostatin M antibodies
    Patent number: 9163083
    Abstract: Antibodies and compositions capable of neutralizing oncostatin M biological functions are useful in treating diseases and disorders associated with oncostatin M, such as osteoarthritis and idiopathic pulmonary fibrosis.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: October 20, 2015
    Inventors: Juan Carlos Almagro, William DuBell, Johan Fransson, Jose Pardinas, Gopalan Raghunathan
  • Human anti-CD27 antibodies, methods and uses
    Patent number: 9102737
    Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: August 11, 2015
    Assignee: Janssen Biotech, Inc.
    Inventors: John Chen, Johan Fransson, Natalie Fursov, Damon Hamel, Thomas Malia, Galina Obmolova, Tatiana Ort, Michael Rycyzyn, Michael Scully, Raymond Sweet, Alexey Teplyakov, John Wheeler, Juan Carlos Almagro
  • Display of disulfide linked dimeric proteins in filamentous phage
    Patent number: 8728985
    Abstract: Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion polypeptide with filamentous phage pIX coat protein. Heterodimeric or more complex interchain bonded structure, such as disulfide-linked, multimeric proteins, may be displayed using the method of the invention.
    Type: Grant
    Filed: November 15, 2010
    Date of Patent: May 20, 2014
    Assignee: Centocor Ortho Biotech Inc.
    Inventors: Chichi Huang, Tracy Spinka-Doms, Johan Fransson
  • Human Oncostatin M Antibodies and Methods of Use
    Publication number: 20140099315
    Abstract: Antibodies and compositions capable of neutralizing oncostatin M biological functions are useful in treating diseases and disorders associated with oncostatin M, such as osteoarthritis and idiopathic pulmonary fibrosis.
    Type: Application
    Filed: December 12, 2013
    Publication date: April 10, 2014
    Inventors: Juan Carlos Almagro, William DuBell, Johan Fransson, Jose Pardinas, Gopalan Raghunathan
  • Methods of affinity maturing antibodies
    Patent number: 8580714
    Abstract: The invention relates to methods of affinity maturing antibodies.
    Type: Grant
    Filed: October 14, 2010
    Date of Patent: November 12, 2013
    Assignee: Janssen Biotech, Inc.
    Inventors: Juan Carlos Almagro, Johan Fransson, Gopalan Raghunathan
  • HUMAN ANTI-CD27 ANTIBODIES, METHODS AND USES
    Publication number: 20130243795
    Abstract: Human antibodies immunospecific for human CD27 are capable of blocking CD27 binding to its ligand CD70 and neutralizing bioactivity of CD27 including, but not limited to, CD27 intracellular signaling, T-cell proliferation and activation, B-cell proliferation and differentiation, plasmablast formation and alleviation of antibody responses, stimulation of tumor cells by CD70, and the production of soluble mediators from T and B-cells. The antibodies are useful in diagnosing or treating CD27 activity associated diseases and conditions.
    Type: Application
    Filed: March 15, 2013
    Publication date: September 19, 2013
    Applicant: JANSSEN BIOTECH, INC.
    Inventors: John Chen, Johan Fransson, Natalie Fursov, Damon Hamel, Thomas Malia, Galina Obmolova, Tatiana Ort, Michael Rycyzyn, Michael Scully, Raymond Sweet, Alexey Teplyakov, John Wheeler, Juan Carlos Almagro
  • Engineered anti-IL-13 antibodies, compositions, methods and uses
    Patent number: 8399630
    Abstract: The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
    Type: Grant
    Filed: August 11, 2009
    Date of Patent: March 19, 2013
    Assignee: Centocor Ortho Biotech Inc.
    Inventors: Ronald V. Swanson, Ellen Chi, Gopalan Raghunathan, Shanrong Zhao, Johan Fransson, Wendy Cordier, Hong Mimi Zhou, Juan C. Almagro, Linus Hyun, Jill Giles-Komar, Karyn T. O'Neil, Jill M. Carton, Alexey V. Teplyakov, Yiqing Feng
  • Engineered anti-IL-13 antibodies, compositions, methods and uses
    Patent number: 8323646
    Abstract: The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
    Type: Grant
    Filed: August 12, 2009
    Date of Patent: December 4, 2012
    Assignee: Centocor Ortho Biotech Inc.
    Inventors: Ronald V. Swanson, Ellen Chi, Gopalan Raghunathan, Shanrong Zhao, Johan Fransson, Wendy Cordier, Hong Mimi Zhou, Juan C. Almagro, Linus Hyun, Jill Giles-Komar, Karyn T. O'Neil, Jill M. Carton, Alexey V. Teplyakov, Yiging Feng
  • DISPLAY OF DISULFIDE LINKED DIMERIC PROTEINS IN FILAMENTOUS PHAGE
    Publication number: 20120225085
    Abstract: Methods are provided for the display of a complex homodimer protein on the surface of a bacteriophage particle and combinatorial synthetic libraries of such proteins displayed as a fusion polypeptide with filamentous phage pIX coat protein. Heterodimeric or more complex interchain bonded structure, such as disulfide-linked, multimeric proteins, may be displayed using the method of the invention.
    Type: Application
    Filed: November 15, 2010
    Publication date: September 6, 2012
    Inventors: Chichi Huang, Tracy Spinka-Doms, Johan Fransson
  • Human Oncostatin M Antibodies and Methods of Use
    Publication number: 20120093833
    Abstract: Antibodies and compositions capable of neutralizing oncostatin M biological functions are useful in treating diseases and disorders associated with oncostatin M, such as osteoarthritis and idiopathic pulmonary fibrosis.
    Type: Application
    Filed: October 10, 2011
    Publication date: April 19, 2012
    Inventors: Juan Carlos Almagro, William DuBell, Johan Fransson, Jose Pardinas
  • ENGINEERED ANTI-IL-13 ANTIBODIES, COMPOSITIONS, METHODS AND USES
    Publication number: 20120045438
    Abstract: The present invention relates to engineered antibodies immuno specific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
    Type: Application
    Filed: August 11, 2009
    Publication date: February 23, 2012
    Inventors: Ronald V. Swanson, Ellen Chi, Gopalan Raghunathan, Shanrong Zhao, Johan Fransson, Wendy Cordier, Hong Mimi Zhou, Juan C. Almagro, Linus Hyun, Jill Giles-Komar, Karyn T. O'Neil, Jill M. Carton, Alexey V. Teplyakov, Yiqing Feng
  • Methods of Affinity Maturing Antibodies
    Publication number: 20110092372
    Abstract: The invention relates to methods of affinity maturing antibodies.
    Type: Application
    Filed: October 14, 2010
    Publication date: April 21, 2011
    Inventors: JUAN CARLOS ALMAGRO, JOHAN FRANSSON, GOPALAN RAGHUNATHAN
  • Methods of Humanizing and Affinity-Maturing Antibodies
    Publication number: 20100261620
    Abstract: Methods of humanizing and affinity-maturing antibodies are disclosed.
    Type: Application
    Filed: October 14, 2009
    Publication date: October 14, 2010
    Inventors: Juan Carlos Almagro, Ramachandra Reddy, Johan Fransson
  • ENGINEERED ANTI-IL-13 ANTIBODIES, COMPOSITIONS, METHODS AND USES
    Publication number: 20100111959
    Abstract: The present invention relates to engineered antibodies immunospecific for human interleukin-13 (IL-13) protein or fragment thereof, as well as methods of making and using thereof, including therapeutic indications.
    Type: Application
    Filed: August 12, 2009
    Publication date: May 6, 2010
    Inventors: Ronald V. Swanson, Ellen Chi, Gopalan Raghunathan, Shanrong Zhao, Johan Fransson, Wendy Cordier, Hong Mimi Zhou, Juan C. Almagro, Linus Hyun, Jill Giles-Komar, Karyn T. O'Neil, Jill M. Carton, Alexey V. Teplyakov
  • AGENT, COMPOSITION AND METHOD
    Publication number: 20090285750
    Abstract: The present application relates to agents, compositions and methods for use in medicine. In particular, the application relates to an agent comprising a binding moiety capable of selectively binding to Ku protein for use in medicine, in particular in the treatment and diagnosis of cancers.
    Type: Application
    Filed: April 11, 2007
    Publication date: November 19, 2009
    Inventors: Carl Borrebaeck, Johan Fransson