Abstract: The invention provides a porous biological assay substrate suitable for detecting at least one analyte in a biological sample fluid. The substrate comprises one or more capture probes able to each specifically bind one target analyte. The average concentration of the capture probes in pores with a size larger than the O50 of the substrate pore size distribution is at least equal to the average concentration of the capture probes in pores with a size smaller than the O50. The substrate thereby shows improved binding efficiency. The invention also relates to a method and device for producing the biological assay substrate, and to a method for examining analyte fluids using the substrate.

Abstract: A medicament delivery device, which comprises a driving mechanism and a housing (1) having a reservoir (2), which is at least partly filled with a substance and which is sealed at least on one side with a flexible wall (21). The driving mechanism is adapted to press a piston (23) against the flexible wall (21) thereby releasing the substance from the reservoir (2) through an opening (25) in the reservoir (2). This provides for a safe and reliable medicament delivery device.

Abstract: A fluid sensor for use within the gastro-intestinal tract of a human being is disclosed. The sensor includes a sensing coil which is immersible in the sample fluid of the gastro-intestinal tract; a signal generator in electrical with the sensing coil for applying an electrical current pulse to the sensing coil; a signal receiver in communication with the sensing coil for measuring an electrical reflection relative to said electrical current pulse; and a data processor for receiving the electrical reflection and for calculating data representative of at least one property, such as pH of the sample fluid based on the electrical reflection. The fluid sensor can also include a reference coil for calibrating the sensing coil. The sensor coil and reference coil can be encapsulated in a swallowable pill shell. The sensor coil can also function as an antenna for transmitting and receiving signals to/form a remote location.

Abstract: An ingestible electronic capsule (100) for introduction into the bodily lumen comprises a circuit board with at least one electronic component (4,5,7,8,9,11, 12, 13, 14). The circuit board is formed from a flex foil (10), thereby reducing the number of components and improving the robustness and reliability of the ingestible electronic capsule (100).

Abstract: A capsule and methodology for dispensing a medicament in the gastrointestinal tract of a mammal is disclosed, the gastrointestinal tract having tissue sites of interest. The capsule may include a medicament reservoir; medicament dispensing means such as a plurality of piezoelectric droplet jet nozzle dispensers; a power source; electronic control circuitry means and/or detecting means capable of communicating with a medicament dispensing means for regulating the amount and time interval for dispensing of the medicament into the gastrointestinal tract by the medicament dispensing means; and a non-digestible outer protective shell housing, e.g., the medicament reservoir, medicament dispensing means and electronic control circuitry means.

Abstract: A sensor comprising a plurality of electrodes having a miniature size and a lower power consumption and a coating exterior to the electrodes, wherein the coating interacts with a target condition thereby producing a change in an electrical property of the electrodes, wherein the change is transduced into an electrical signal by the electrodes. Further a system for medication delivery comprising such sensor and a pill.

Abstract: The invention provides an ink jet device for producing a biological assay substrate. The device releases a plurality of substances onto the substrate from print heads, provided with the substances. The device further comprises means to subject the printed substrates to an accelerated motion. The accelerated motion which acts about perpendicular to the surface of the substrates acts to control penetration of the substances into the substrate. The invention also relates to a method for producing a biological assay substrate, and to a biological assay substrate obtainable by such method.

Abstract: The invention provides an ink jet device for producing a biological assay substrate by releasing a plurality of substances onto the substrate, the device comprising at least a print head comprising a nozzle, the device comprising at least a transducer provided to eject a droplet out of the nozzle, wherein a detection means is assigned to the ink jet device such that the state of the print head can be monitored by means of the detection of the behaviour of to the transducer.

Abstract: The invention refers to an electrically actuated, needle-free injection device. The main field of application is drug delivery. The device is based on a piezoelectric actuator (11). The device enables controlled, continuous, tuneable drug delivery. The device enables painless injection, personalized and programmable dosage profiles. The device is designed, both to pierce the epidermis for trans-epidermal drug delivery and to deliver controlled amounts of fluid (transdermal, electronic pill and implantable drug delivery). This type of device enables personalized drug delivery and is an enabling component for closed-loop drug delivery systems.

Abstract: An imprint lithography apparatus is disclosed that has a first array of template holders, a second array of template holders, and a substrate table arranged to support a substrate to be imprinted, wherein the first array of template holders is arranged to hold an array of imprint templates that can be used to imprint a first array of patterns onto the substrate, and the second array of template holders is arranged hold an array of imprint templates that can be used to imprint a second array of patterns onto the substrate, the patterns imprinted by the second array being interspersed between the patterns imprinted by the first array.

Abstract: The invention relates to a printer device for producing biological test arrays by depositing an array of biofluids onto a substrate. The invention further relates to the use of such a device in the production of biological test arrays. The invention also relates to a method for producing a biological test array. The invention moreover relates to a biological test array. The method according to the invention is failure-proof, and results in biological test arrays of superior quality.

Abstract: An imprint lithography apparatus is disclosed that includes a support structure configured to hold an imprint template. The apparatus further includes an actuator located between the support structure and a side of the imprint template, when the imprint template is held by the support structure, configured to apply a force to the imprint template and a force sensor between the support structure and a side of the imprint template, when the imprint template is held by the support structure.

Abstract: An imprint lithography apparatus is disclosed that has a first array of template holders, a second array of template holders, and a substrate table arranged to support a substrate to be imprinted, wherein the first array of template holders is arranged to hold an array of imprint templates that can be used to imprint a first array of patterns onto the substrate, and the second array of template holders is arranged hold an array of imprint templates that can be used to imprint a second array of patterns onto the substrate, the patterns imprinted by the second array being interspersed between the patterns imprinted by the first array.

Abstract: A chuck apparatus for holding a substrate is the disclosed. The chuck apparatus includes a first surface portion on which the substrate is to be held and a second surface portion adjacent to the first surface portion and extending at least partially around an edge of the first surface portion and which, in use, is arranged to deflect gas over the first surface portion and thus the substrate that is to be held on the first surface portion.

Abstract: An imprint lithography method is disclosed, which includes imprinting a plurality of patterns in an imprintable medium provided on a substrate, wherein the order in which the patterns are imprinted in the imprintable medium is such that, for the majority of the patterns, two consecutively imprinted patterns are not imprinted adjacent to one another.

Abstract: The invention provides an ink jet device for releasing a plurality of substances onto a substrate, the device comprising at least one print head, which is positionable relative to the substrate, and which comprises at least one nozzle, provided to eject a droplet. The ink jet device is designed such that the plurality of substances can be deposited onto the substrate in a predefined pattern in a limited amount of moves of the at least one print head relative to the substrate.

Abstract: A method for controlling printing actions of a print head (1) comprising pumps (10) filled with ink (18), and actuators (16) for generating actuation pulses acting on the ink(18), comprises the step of determining a characteristic frequency of the pumps (10). As the characteristic frequency of the pumps (10) is directly related to the geometry of the pumps (10), the characteristic frequency can be used as an indicator of the state of the pumps (10) and the volume of the ink droplets emitted by the pumps (10). In case a slight change of the characteristic frequency is detected, the actuation pulse is adjusted in order to still meet the requirements regarding the volume of the ink droplets. In case a relatively large change of the characteristic frequency is detected, the printing action of the pump (10) concerned is stopped, and may be taken over by another pump (10).

Abstract: The invention provides an ink jet device for releasing controllably a plurality of substances onto a substrate, the device comprising at least a print head comprising a nozzle, the device comprising at least a transducer provided to eject a droplet out of the nozzle, wherein a detection means is assigned to the ink jet device such that the substances are discriminable from each other by means of the detection of the behaviour of the transducer.

Abstract: The invention provides an ink jet device (10) for producing a biological assay-substrate by releasing a plurality of substances onto the substrate, the device comprising printing means (20), detection means (30,32,45,45?), filling means and cleaning means (120), and wherein the ink jet device further comprises control means for an automated production such that the production of the biological assay substrate is error tolerant for a multitude of error sources.

Abstract: The invention provides an ink jet device for the controlled positioning of droplets of a substance onto a substrate, the device comprising at least a print head with a nozzle designed to eject the droplet, the device further comprising at least one acoustic sensor arranged for detecting the landing of the droplet on the substrate. A feedback loop stops the printing process the moment the landing of a droplet is not detected within a predetermined delay time.