Abstract: This disclosure provides methods for treating a subject having small cell lung cancer by determining expression levels of biomarkers highly correlated with a subtype of small cell lung cancer that are sensitive to treatment with pentamidine or a pharmaceutically acceptable salt thereof. The methods are drawn to determining a predictive gene expression profile of a subtype of small cell lung cancer and treating the subject with an effective amount of pentamidine or a pharmaceutically acceptable salt of pentamidine as a chemotherapy agent. The methods generally involve treatment of a subtype of small cell lung cancer predicted to be a responder to pentamidine or a pharmaceutically acceptable salt of pentamidine.

Abstract: An example method comprises receiving historical information of episodes, constructing event sets from the historical information, categorizing each event with general labels and synthetic labels, learning an event metric on the events by using the general and synthetic labels to perform dimensionality reduction to associate a vector with each event and to determine an angle between every two vectors, determining an event set metric using distances between each pair of event sets, deriving a sequence metric on the episodes, the sequence metric obtaining a preferred match between two episodes, deriving a subsequence metric on the episodes, the subsequence metric is a function of the event set metric on subsequences of each episode, grouping episodes into subgroups based on distances, for at least one subgroup, generating a consensus sequence by finding a preferred sequence of events, and the episodes of the subgroup, and generating a report indicating the consensus sequence.

Abstract: An example method comprises receiving historical information of episodes, constructing event sets from the historical information, categorizing each event with general labels and synthetic labels, learning an event metric on the events by using the general and synthetic labels to perform dimensionality reduction to associate a vector with each event and to determine an angle between every two vectors, determining an event set metric using distances between each pair of event sets, deriving a sequence metric on the episodes, the sequence metric obtaining a preferred match between two episodes, deriving a subsequence metric on the episodes, the subsequence metric is a function of the event set metric on subsequences of each episode, grouping episodes into subgroups based on distances, for at least one subgroup, generating a consensus sequence by finding a preferred sequence of events, and the episodes of the subgroup, and generating a report indicating the consensus sequence.

Abstract: An example method comprises receiving historical information of episodes, constructing event sets from the historical information, categorizing each event with general labels and synthetic labels, learning an event metric on the events by using the general and synthetic labels to perform dimensionality reduction to associate a vector with each event and to determine an angle between every two vectors, determining an event set metric using distances between each pair of event sets, deriving a sequence metric on the episodes, the sequence metric obtaining a preferred match between two episodes, deriving a subsequence metric on the episodes, the subsequence metric is a function of the event set metric on subsequences of each episode, grouping episodes into subgroups based on distances, for at least one subgroup, generating a consensus sequence by finding a preferred sequence of events, and the episodes of the subgroup, and generating a report indicating the consensus sequence.

Abstract: An example method comprises receiving historical information of episodes, constructing event sets from the historical information, categorizing each event with general labels and synthetic labels, learning an event metric on the events by using the general and synthetic labels to perform dimensionality reduction to associate a vector with each event and to determine an angle between every two vectors, determining an event set metric using distances between each pair of event sets, deriving a sequence metric on the episodes, the sequence metric obtaining a preferred match between two episodes, deriving a subsequence metric on the episodes, the subsequence metric is a function of the event set metric on subsequences of each episode, grouping episodes into subgroups based on distances, for at least one subgroup, generating a consensus sequence by finding a preferred sequence of events, and the episodes of the subgroup, and generating a report indicating the consensus sequence.