Patents by Inventor Johan H. Geerke
Johan H. Geerke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8936810Abstract: Rapid and accurate determination of the formulation orientation of multi-layer capsule-shaped tablets with respect to different internal formulation layers proximate to the opposite narrow and rounded ends of the tablets is required. By including an appropriate color scheme in multi-layer osmotic tablets, detection of the formulation orientation is achieved by detecting the color at a spot location on a side of the tablet corresponding to one or another formulation layer or to one or another interface of two formulation layers depending on the formulation orientation of the tablet.Type: GrantFiled: October 18, 2012Date of Patent: January 20, 2015Assignee: ALZA CorporationInventors: Steven F. Stone, Johan H. Geerke
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Patent number: 8323691Abstract: Rapid and accurate determination of the formulation orientation of multi-layer capsule-shaped tablets with respect to different internal formulation layers proximate to the opposite narrow and rounded ends of the tablets is required. By including an appropriate color scheme in multi-layer osmotic tablets, detection of the formulation orientation is achieved by detecting the color at a spot location on a side of the tablet corresponding to one or another formulation layer or to one or another interface of two formulation layers depending on the formulation orientation of the tablet.Type: GrantFiled: March 11, 2009Date of Patent: December 4, 2012Assignee: Alza CorporationInventors: Johan H. Geerke, Steven F. Stone
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Publication number: 20090186085Abstract: Rapid and accurate determination of the formulation orientation of multi-layer capsule-shaped tablets with respect to different internal formulation layers proximate to the opposite narrow and rounded ends of the tablets is required. By including an appropriate color scheme in multi-layer osmotic tablets, detection of the formulation orientation is achieved by detecting the color at a spot location on a side of the tablet corresponding to one or another formulation layer or to one or another interface of two formulation layers depending on the formulation orientation of the tablet.Type: ApplicationFiled: March 11, 2009Publication date: July 23, 2009Inventors: Johan H. Geerke, Steven F. Stone
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Patent number: 7521067Abstract: Rapid and accurate determination of the formulation orientation of multi-layer capsule-shaped tablets with respect to different internal formulation layers proximate to the opposite narrow and rounded ends of the tablets is required. By including an appropriate color scheme in multi-layer osmotic tablets, detection of the formulation orientation is achieved by detecting the color at a spot location on a side of the tablet corresponding to one or another formulation layer or to one or another interface of two formulation layers depending on the formulation orientation of the tablet.Type: GrantFiled: June 2, 1999Date of Patent: April 21, 2009Assignee: Alza CorporationInventors: Johan H Geerke, Steven F. Stone
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Patent number: 7011850Abstract: A dosage form for delivery of a therapeutic agent to a subject is described. The dosage form contains: (a) an outer wall defining an interior compartment; (b) within the interior compartment, a therapeutic agent; (c) at least one exit orifice formed by laser ablation of the outer wall for release of the agent therethrough, and (d) a barrier layer disposed between the outer wall and the interior compartment in at least a region corresponding to the exit orifice. The barrier layer comprises a material that allows the barrier layer to remain intact during laser-formation of the at least one exit orifice in the outer wall. Also disclosed is a method for controlling the depth of laser ablation of a dosage form during laser formation of an exit orifice in an outer wall of the dosage form.Type: GrantFiled: December 13, 2000Date of Patent: March 14, 2006Assignee: Alza CorporationInventor: Johan H. Geerke
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Patent number: 6452133Abstract: Methods and apparatus for laser treating batches of pharmaceutical dispensers are provided. Sequential batches of untreated dispensers are carried on alternate batch carriers that are advanced into associated alternate stationary laser treatment stations. The multiple stationary laser treatment stations are located within a region of adjacency in which a single laser source can be operated to treat alternate batches of dispensers positioned within the associated alternate laser treatment stations. A laser controller directs the laser beam to alternatingly operate in each laser treatment station and, within each laser treatment station, to treat each dispenser in a batch of dispensers positioned therein. An advance coordinator advances the batch carriers in coordination with the activity of the laser controller in a repeating alternating cycle.Type: GrantFiled: July 14, 2000Date of Patent: September 17, 2002Assignee: Alza CorporationInventors: Johan H. Geerke, Keith Perry Minton
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Publication number: 20020071866Abstract: A dosage form for delivery of a therapeutic agent to a subject is described. The dosage form contains: (a) an outer wall defining an interior compartment; (b) within the interior compartment, a therapeutic agent; (c) at least one exit orifice formed by laser ablation of the outer wall for release of the agent therethrough, and (d) a barrier layer disposed between the outer wall and the interior compartment in at least a region corresponding to the exit orifice. The barrier layer comprises a material that allows the barrier layer to remain intact during laser-formation of the at least one exit orifice in the outer wall. Also disclosed is a method for controlling the depth of laser ablation of a dosage form during laser formation of an exit orifice in an outer wall of the dosage form.Type: ApplicationFiled: December 13, 2000Publication date: June 13, 2002Inventor: Johan H. Geerke
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Patent number: 6276512Abstract: An inverter for reversing the orientation of a pharmaceutical dosage form at a discontinuity in a path of travel is described. The inverter receives dosage forms from an input path and delivers rectified dosage forms to an output path. In addition, a dosage form rectifier comprising an inverter is described. The dosage form rectifier receives randomly oriented dosage forms and delivers uniformly oriented dosage forms without recycling any of the dosage forms. In a repeating cycle for each dosage form supplied to the rectifier, the orientation of the dosage form is determined and dosage forms having a desired orientation are maintained in the desired orientation and delivered from the dosage form rectifier while dosage forms having an inverted orientation have their orientation rectified at the inverter before being delivered from the dosage form rectifier.Type: GrantFiled: May 20, 1999Date of Patent: August 21, 2001Assignee: Alza CorporationInventors: Johan H. Geerke, Antonio A. Crisologo
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Patent number: 5698119Abstract: An apparatus for forming delivery ports in beneficial agent dispensers with a laser beam. The apparatus includes a conveyor conveying the dispensers. The dispensers have a compartment formed by a wall and contain a beneficial agent to be delivered. A laser source produces laser energy to form a channel at least partially surrounding a removable central plug. The channel and the removable plug define the delivery port in the beneficial agent dispenser.Type: GrantFiled: June 25, 1996Date of Patent: December 16, 1997Assignee: ALZA CorporationInventor: Johan H. Geerke
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Patent number: 5658474Abstract: A method of laser drilling a delivery port (37) in a beneficial agent dispenser (30) is disclosed. A dispenser (30) has a compartment (32) formed by a wall (31) for containing a beneficial agent (33) to be delivered. A laser beam is employed for burning at least partially through the wall (31). The laser beam and the dispenser (30) are positioned relative to one another such that the laser beam is aimed at a predetermined port site (35) on the dispenser (30). The laser beam is turned off (unenergized) during the positioning period. The laser beam is then energized and moved relative to the dispenser (30) for scribing a delivery port (37) proximate the port site (35). The scribing motion moves the laser beam from the port site (35) along a course (37). Preferably the course (37) is closed. The scribing motion causes the burning of the wall (31) by the laser beam to scribe the delivery port (37). The positioning motion and the scribing motion are controlled by a scanning system (16).Type: GrantFiled: December 16, 1994Date of Patent: August 19, 1997Assignee: Alza CorporationInventor: Johan H. Geerke
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Patent number: 5399828Abstract: Tablet treating system 10 treats a series of pharmaceutical tablets 50T with pulses of laser energy 24P within at least one predetermined treatment site 50S on each tablet. A tablet conveyer 12 continuously moves individual tablets along a tablet path 10P. A Laser 14 provides the pulses of laser energy along a stationary laser path which crosses the tablet path defining a stationary intersection zone 14Z common to both paths. The tablet path has periodic treatment windows 20W during which the treatment sites 50S on the moving tablets pass through the stationary intersection zone. The operation of the laser has periodic laser ready windows 24W during which the laser may be fired. A controller 16 is responsive to the movement of the tablet conveyer and to the operation of the laser for activating the laser and treating the tablets. The controller activates the laser when a tablet is passing through the intersection zone and the tablet treatment window coincides with the laser ready window.Type: GrantFiled: November 16, 1993Date of Patent: March 21, 1995Assignee: Alza CorporationInventors: Thomas A. Riddle, Johan H. Geerke, Keith P. Minton
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Patent number: 5294770Abstract: Tablet treating system 10 treats a series of pharmaceutical tablets 50T with pulses of laser energy 24P within at least one predetermined treatment site 50S on each tablet. A tablet conveyer 12 continuously moves individual tablets along a tablet path 10P. A Laser 14 provides the pulses of laser energy along a stationary laser path which crosses the tablet path defining a stationary intersection zone 14Z common to both paths. The tablet path has periodic treatment windows 20W during which the treatment sites 50S on the moving tablets pass through the stationary intersection zone. The operation of the laser has periodic laser ready windows 24W during which the laser may be fired. A controller 16 is responsive to the movement of the tablet conveyer and to the operation of the laser for activating the laser and treating the tablets. The controller activates the laser when a tablet is passing through the intersection zone and the tablet treatment window coincides with the laser ready window.Type: GrantFiled: January 14, 1992Date of Patent: March 15, 1994Assignee: Alza CorporationInventors: Thomas A. Riddle, Johan H. Geerke, Keith P. Minton
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Patent number: 4320758Abstract: An improved version of an osmotically driven mini-osmotic pump that is used to administer drug solutions. The basic components of the improved pump are: an inner flexible bag that holds the drug solution; a plug having a recessed inner end that seals the bag opening; a solution filling/discharge port through the plug; a cup-shaped, thermo-formed sleeve that fits partly about the bag and is made from a dispersion of an osmotically effective solute in a water soluble, theroplastic polymer vehicle; a shape-retaining, semipermeable membrane that encapulates the bag-sleeve subassembly; and a flow moderator that is received through the filling/discharge port in the plug.Type: GrantFiled: December 8, 1980Date of Patent: March 23, 1982Assignee: Alza CorporationInventors: James B. Eckenhoff, Johan H. Geerke, Felix A. Landrau