Abstract: A control unit for a heavy road vehicle combination, configured to obtain sensor readouts of a state of an active suspension element of a drawbar coupling together first and second vehicle units of the vehicle combination, wherein the state is indicative of a longitudinal force exerted by the first vehicle unit, and to control the vehicle combination based on the readouts, wherein, as part of the control, the control unit is further configured to detect an imminent jack-knifing situation based on the readouts, command a compression or elongation of the active suspension element to cause or extend a delay of a force exerted on the second vehicle unit by the drawbar, and prepare the vehicle combination to avoid or at least alleviate the jack-knifing situation during the delay. A corresponding drawbar arrangement, heavy towing vehicle and heavy vehicle combination are also provided.

Abstract: A method of determining actuator brake torque limits for a plurality of actuators, wherein each actuator is operable to apply a brake torque on a wheel of a vehicle, the method comprising determining, for each actuator, an actuator brake torque capability range based on an actuator specific torque capacity and a current operational state of the actuator; determining, for each wheel of the vehicle, a road condition brake torque capability range based on an estimated lateral wheel force acting on the wheel, an estimated friction between a tire surface of the wheel and a road surface, and a vertical wheel force acting on the wheel; and determining, for each actuator, an upper actuator brake torque limit and a lower actuator brake torque limit based on the actuator brake torque capability range and the road condition brake torque capability range.

Abstract: A hydraulic system comprising: a hydraulic fluid pressure source, a hydraulic fluid reservoir, a hydraulically driven actuator having a first chamber and a second chamber, and a valve assembly having a first pilot-operated directional control valve and a second pilot-operated directional control valve, each including: an inlet port fluidly connected for receiving high-pressure hydraulic fluid from the hydraulic fluid pressure source, an outlet port fluidly connected for draining hydraulic fluid to the hydraulic fluid reservoir, a first actuator port fluidly coupled with the first chamber of the hydraulically driven actuator, a second actuator port fluidly coupled with the second chamber of the hydraulically driven actuator; first to fourth fail-safe solenoid-controlled pilot valves; and a pilot pressure fluid supply system.

Abstract: A coupler head for a coupling arrangement is shown, which coupler head includes a coupler head housing (6) extending in a longitudinal direction from a first end (6a), attachable to a drawbar, to a second end (6b), which is arranged to carry a coupling interface between coupled rail vehicles, which coupler head housing houses mechanical coupling components (8,9) effective for automatic coupling to the corresponding components of a connecting coupling arrangement. The coupler head is characterized in that the coupler head housing has at least one notch (11, 11?) for a predetermined and primarily axial compression thereof with absorption of energy from a deforming compressive force that is applied to the coupler head in the longitudinal direction thereof. The coupler head has preferably at least one notch (11, 11?) for a predetermined folding of the coupler head housing.

Abstract: A coupler head for a coupling arrangement is shown, which coupler head includes a coupler head housing (6) extending in a longitudinal direction from a first end (6a), attachable to a drawbar, to a second end (6b), which is arranged to carry a coupling interface between coupled rail vehicles, which coupler head housing houses mechanical coupling components (8,9) effective for automatic coupling to the corresponding components of a connecting coupling arrangement. The coupler head is characterized in that the coupler head housing has at least one notch (11, 11?) for a predetermined and primarily axial compression thereof with absorption of energy from a deforming compressive force that is applied to the coupler head in the longitudinal direction thereof. The coupler head has preferably at least one notch (11, 11?) for a predetermined folding of the coupler head housing.

Abstract: The present invention relates to a combination of (a) a chemokine receptor 1 (CCR1) antagonist and (b) a muscarinic antagonist. The invention further relates to pharmaceutical compositions comprising said combination and to methods of treatment of airway diseases, such as chronic obstructive pulmonary disease (COPD) and asthma in mammals by administrating said combination. The invention further relates to a kit comprising the combination and use of said kit in treatment of airway diseases.

Abstract: The present invention provides a pharmaceutical product comprising, in combination of, (a) a (therapeutically effective) dose of a first active ingredient, which is a compound of formula (I) or a pharmaceutically acceptable salt thereof; and (b) a (therapeutically effective) dose of a second active ingredient, which is a glucocorticoid receptor agonist; and optionally, (c) a (therapeutically effective) dose of a third active ingredient, which is a ?2-agonist. The invention further relates to pharmaceutical compositions comprising said combination and to methods of treating treatment of airway diseases, especially chronic obstructive pulmonary disease (COPD) and asthma in mammals by administrating said combination. The invention further relates to a kit comprising the combination and use of said kit in treatment of airway diseases such as COPD and asthma.

Abstract: A sensor arrangement is arranged to detect at least one position of a displaceable component in a fluid device, which fluid device comprises a wall enclosing a cavity, in which cavity the component is displaced by pressurized fluid selectively applied to the component. The sensor arrangement includes a magnetic sensor mounted outside the wall and a first sensor element that is connected to the magnetic sensor and extends through the wall and a predetermined distance into the cavity. The magnetic sensor is arranged to detect the position of at least one predetermined second sensor element located on the displaceable component by sensing a change in magnetic flux induced in the first sensor element by the second sensor element.

Abstract: The present invention provides pharmaceutical compositions comprising a ?2-agonist, and a compound of formula: wherein m, R1, R2, R3, and R4 are as defined in the specification, and their use in therapy.

Abstract: A sensor arrangement is arranged to detect at least one position of a displaceable component in a fluid device, which fluid device comprises a wall enclosing a cavity, in which cavity the component is displaced by pressurized fluid selectively applied to the component. The sensor arrangement includes a magnetic sensor mounted outside the wall and a first sensor element that is connected to the magnetic sensor and extends through the wall and a predetermined distance into the cavity. The magnetic sensor is arranged to detect the position of at least one predetermined second sensor element located on the displaceable component by sensing a change in magnetic flux induced in the first sensor element by the second sensor element.

Abstract: The present invention provides pharmaceutical compositions comprising a glucocorticosteroid and a compound of formula: wherein m, R1, R2, R3, and R4 are as defined in the specification, and their use in therapy.

Abstract: A conjugate between a target-seeking moiety and a modified superantigen, characterized in that the superantigen is a wild-type superantigen (SA I) in which an amino acid residue in a superantigen region (region I) determining binding to TCR, preferably TCRV?, and T cell activation have been replaced by another amino acid residue while retaining the ability to activate a subset of T cells. In preferred embodiment the modified superantigen is a chimer between at least two wild-type superantigens (SA I, SA II etc) characterized in that one or more amino acid residues in a region determining binding to TCR and T cell activation have been interchanged between various wild-type superantigens. A therapeutic method making use of modified/chimeric superantigens as defined in the preceding paragraphs. An antibody preparation in which the cysteine residues that provide for interchain disulfide bonds have been mutated so as to forbid interchain disulfide bridges, preferably to serine residues, for use as pharmaceutical.

Abstract: A message that comprises encoded bits interleaved over N transmission bursts, wherein N is greater than 1, is received by receiving fewer than N of the transmission bursts, whereby there exist remaining ones of the N transmission bursts that have not been received. All of the received transmission bursts are decoded to generate decoded data. It is then determined whether the decoded data is error free. Reception of remaining transmission bursts of the message is inhibited if the decoded data is error free, otherwise one or more remaining ones of the N transmission bursts are received.

Abstract: A technique for estimating current consumption of an electronic device such that current consumed during reception of bursts is utilized in calculating the remaining battery power. By determining the time duration of each reception burst and the charge consumed during each burst, the total charge consumed by the reception bursts is calculated. The total charge calculated is used to determine the remaining battery power.

Abstract: A technique for estimating current consumption of an electronic device such that current consumed during reception of bursts is utilized in calculating the remaining battery power. By determining the time duration of each reception burst and the charge consumed during each burst, the total charge consumed by the reception bursts is calculated. The total charge calculated is used to determine the remaining battery power.

Abstract: A conjugate between a target-seeking moiety and a modified superantigen, characterized in that the superantigen is a wild-type superantigen (SA I) in which an amino acid residue in a superantigen region (region I) determining binding to TCR, preferably TCRV&bgr;, and T cell activation have been replaced by another amino acid residue while retaining the ability to activate a subset of T cells.

Abstract: A conjugate between a target-seeking moiety and a modified superantigen, characterized in that the superantigen is a wild-type superantigen (SA I) in which an amino acid residue in a superantigen region (region I) determining binding to TCR, referably TCRV&bgr;, and T cell activation has been replaced by another amino acid residue while retaining the ability to activate a subset of T cells. In a preferred embodiment the modified superantigen is a chimer between at least two wild-type superantigens (SA I, SA II etc) characterized in that one or more amino acid residues in a region determining binding to TCR and T cell activation have been interchanged between various wild-type superantigens. A therapeutic method making use of modified/chimeric superantigens as defined in the preceding paragraphs.

Abstract: The present invention relates to a guide instrument which is adapted for use at operations for fixation of bone fragments at bone fractures, preferably femoral neck fractures, whereby the bone fragments are intended to be fixed relative to each other by means of at least two bone screws, whereby the guide instrument (1) is adapted for guiding a first and a second drill steel which are adapted for drilling passages in the bone fragments for the bone screws. The guide instrument (1) is designed to permit guiding of the drill steels, driving through of threaded front portions of the bone screws and guiding of uptapped or unthreaded rear portions of said bone screws.