Abstract: The invention relates to an epilating device (10) for epilating hairs growing from skin, comprising a housing; an epilating system having a plurality of hair-clamping elements arranged adjacent to each other rotatably on a curved supporting shaft which extends in a plane of curvature; a drive system arranged (58) to rotate the hair-clamping elements; a skin-contacting member (16) arranged to contact the skin during use and to be pivotable relative to the housing about a first pivot axis; a compression member arranged adjacent to the epilating system to exert a compression force on the epilating system directed along a compression line, said compression member being pivotable relative to the housing about a second pivot axis to adjust a position of the compression line relative to the housing; and a linkage mechanism linking the skin-contacting member and the compression member such that a pivotal motion of the skin-contacting member about the first pivot axis over a first pivot angle results in a pivotal moti

Abstract: The invention relates to an epilating device (10) for epilating hairs growing from skin, comprising a housing; an epilating system having a plurality of hair-clamping elements arranged adjacent to each other rotatably on a curved supporting shaft which extends in a plane of curvature; a drive system arranged (58) to rotate the hair-clamping elements; a skin-contacting member (16) arranged to contact the skin during use and to be pivotable relative to the housing about a first pivot axis; a compression member arranged adjacent to the epilating system to exert a compression force on the epilating system directed along a compression line, said compression member being pivotable relative to the housing about a second pivot axis to adjust a position of the compression line relative to the housing; and a linkage mechanism linking the skin-contacting member and the compression member such that a pivotal motion of the skin-contacting member about the first pivot axis over a first pivot angle results in a pivotal moti

Abstract: A diagnostic portfolio comprising or consisting of isolated nucleic acid molecules, their complement and/or fragments thereof, said nucleic acid molecules, complements, equivalents and/or fragments thereof being represented by sequences comprising or consisting of sequences having at least 80% of sequence identity with SEQ ID NO:1-92, or 49-140 or derived thereof (i.e. groups a), b), c), d), e), f), g), h), i) or j) or subgroups thereof) and their uses.

Abstract: A device for making a predetermined quantity of a hot beverage includes a boiler chamber for heating water and a tubular heating element inside the boiler chamber near the bottom of the boiler chamber. A main portion of the tubular heating element extends along a helical line around a horizontal axis. The bottom of the boiler chamber includes a wall substantially having the shape of a part of cylindrical surface around the horizontal axis.

Abstract: The present invention relates to derivatives of compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such derivatives which comprise a peptide moiety or a functional equivalent of said peptide moiety and are represented by X(Ax)mA3A1A2A1Y. In addition, the invention relates to methods for preparing such compounds, to the use of such compounds in therapeutic or diagnostic methods and in pharmaceutical compositions, to binding molecules binding to said compounds and to a method for determining whether a compound is capable of binding to P-selectin.

Abstract: The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence XAxA3A1A2A1Y, or a functional equivalent of said peptide. In addition, the invention relates to methods for preparing such compounds, to the use of such compounds in therapeutic or diagnostic methods and in pharmaceutical compositions, to nucleic acids encoding for proteinaceous materials comprising the amino acid sequences of said compounds, to gene delivery vehicles comprising such nucleic acids, to binding molecules binding to said compounds, and to a method for determining whether a compound is capable of binding to P-selectin.

Abstract: The present invention relates to derivatives of compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such derivatives which comprise a peptide moiety or a functional equivalent of said peptide moiety and are represented by X(Ax)mA3A1A2A1Y. In addition, the invention relates to methods for preparing such compounds, to the use of such compounds in therapeutic or diagnostic methods and in pharmaceutical compositions, to binding molecules binding to said compounds and to a method for determining whether a compound is capable of binding to P-selectin.

Abstract: A device for making a predetermined quantity of a hot beverage comprising a boiler chamber (5) for heating water and a tubular heating element (6) inside the boiler chamber (5) near the bottom (16) of the boiler chamber (5). A main portion (7) of the tubular heating (6) element extends along a substantial helical line around a substantial horizontal axis. The bottom of the boiler chamber (5) comprises a wall (16) substantially having the shape of a part of cylindrical surface around said horizontal axis.

Abstract: Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenols as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P-selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.

Abstract: Polyhydroxy phenols, which are non-peptidic mimetics of galloyl peptides, and a process for the preparation of gallic acid derivatives using a gallic-acid providing moiety are provided as well as polyhydroxy phenol-containing pharmaceutical and nutraceutical compositions. The use of polyhydroxy phenols as a medicament and especially for the manufacture of a medicament for the prevention, treatment or diagnosis of a disease or a condition, wherein P-selectin is involved, is provided. The same compounds can also be used as targeting tools to P-selectin expressing cells or tissues in a composition, further comprising an active compound in a vehicle.

Abstract: The present invention relates to derivatives of compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such derivatives which comprise a peptide moiety or a functional equivalent of said peptide moiety and are represented by X(Ax)mA3A1A2A1Y. In addition, the invention relates to methods for preparing such compounds, to the use of such compounds in therapeutic or diagnostic methods and in pharmaceutical compositions, to binding molecules binding to said compounds and to a method for determining whether a compound is capable of binding to P-selectin.

Abstract: The present invention relates to compounds which bind selectively to the adhesion molecule human P-selectin, and particularly to such compounds comprising a peptide with an amino acid sequence XAxA3A1A2A1Y, or a functional equivalent of said peptide. In addition, the invention relates to methods for preparing such compounds, to the use of such compounds in therapeutic or diagnostic methods and in pharmaceutical compositions, to nucleic acids encoding for proteinaceous materials comprising the amino acid sequences of said compounds, to gene delivery vehicles comprising such nucleic acids, to binding molecules binding to said compounds, and to a method for determining whether a compound is capable of binding to P-selectin.

Abstract: This invention relates to methods for inhibiting the initiation or progression of a pathologic disorder associated with atherosclerotic plaque formation comprising administering to a subject an amount of IL-9 sufficient to inhibit plaque formation and/or plaque progression and/or to promote plaque regression. The methods of this invention also relate to inhibiting the proliferation of smooth muscle cells in one or more arteries and to inhibiting the deposition and accumulation of fat and proteins in one or more arteries.