Abstract: The present invention relates to DNA sequencing with reagent cycling on the wiregrid. The sequencing approach suggested with which allows to use a single fluid with no washing steps. Based on strong optical confinement and of excitation light and of cleavage light, the sequencing reaction can be read-out without washing the surface. Stepwise sequencing is achieved by using nucleotides with optically cleavable blocking moieties. After read-out the built in nucleotide is deblocked by cleavage light through the same substrate. This ensures that only bound nucleotides will be unblocked.

Abstract: A wavelength converting element (101, 102, 103, 110) comprising a polymeric carrier material comprising a first wavelength converting material adapted to convert light of a first wavelength to light of a second wavelength, wherein the oxygen diffusion coefficient (D) of the polymeric carrier material is 8×10?13 cm2/s or less at 25° C. A prolonged lifetime of the wavelength converting material is achieved by selecting a polymeric carrier material with an oxygen diffusion coefficient (D) at 8×10?13 cm2/s or less at 25° C.

Abstract: The invention provides a lighting device (1) comprising (a) a light source (10) configured to generate light source light (11), and (b) a light converter (100) configured to convert at least part of the light source light (11) into visible converter light (111), wherein the light converter (100) comprises a matrix (120) containing a luminescent material (140) based on derivatives of benzimidazoxanthenoisoquinolinone. The lighting device may further comprise a further luminescent material (130).

Abstract: The present invention relates to DNA sequencing with reagent cycling on the wiregrid. The sequencing approach suggested with which allows to use a single fluid with no washing steps. Based on strong optical confinement and of excitation light and of cleavage light, the sequencing reaction can be read-out without washing the surface. Stepwise sequencing is achieved by using nucleotides with optically cleavable blocking moietys. After read-out the built in nucleotide is deblocked by cleavage light through the same substrate. This ensures that only bound nucleotides will be unblocked.

Abstract: The invention provides a lighting device (1) comprising (a) a light source (10) configured to generate light source light (11), and (b) a light converter (100) configured to convert at least part of the light source light (11) into visible converter light (111), wherein the light converter (100) comprises a matrix (120) containing an organic luminescent material (140) of the perylene type. The lighting device may further comprise an inorganic luminescent material (130).

Abstract: A printing head (100) for a 3-D printing device is disclosed that comprises a nozzle (110) arranged to print a layer (140) of a printing material on a receiving surface (130) and a texturing member (120) arranged to texture the layer or the receiving surface during printing of said layer. The nozzle comprises an outlet including the texturing member (120) and the outlet is shaped to form protrusions (145) extending from a main surface of the layer (140) for interlocking with a subsequent layer. The texturing member ensures that contacting layers formed with the printing head exhibit improved adhesion due to the increased contact surface area between the layers. This yields stronger 3-D articles printed in this manner. A printing apparatus including the printing head, a printing method and an article printed in accordance with the printing method are also disclosed.

Abstract: The invention provides a process for the production of a (particulate) luminescent material comprising particles, especially substantially spherical particles, having a porous inorganic material core with pores, especially macro pores, which are at least partly filled with a polymeric material with a first material embedded therein, wherein the process comprises (i) impregnating the particles of a particulate porous inorganic material with pores with a first liquid (“ink”) comprising the first material and a curable or polymerizable precursor of the polymeric material, to provide pores that are at least partly filled with said first material and curable or polymerizable precursor; and (ii) curing or polymerizing the curable or polymerizable precursor within pores of the porous material, as well as a product obtainable thereby.

Abstract: The invention provides a lighting device comprising a light source configured to provide light source light having a blue light component and a light converter configured to convert at least part of the light source light into converter light, wherein the light converter comprises a polymeric matrix (22) with a luminescent material, wherein the luminescent material comprises a luminescent molecule (300) comprising a first group (310) able to absorb at least part of the blue light component, and a second group (320) able to emit luminescent molecule light having a red light component, wherein the first group (310) is configured to transfer at least part of the energy acquired by the absorption of said blue light component to the second group (320) for generation of said luminescent molecule light having a red light component.

Abstract: The invention provides a luminescent material comprising wavelength converter nanoparticles (120) with siloxane polymer capping ligands (130) associated to the wavelength converter nanoparticles (120), wherein the siloxane polymer capping ligands (130) comprise siloxane polymers which comprise at least one capping group comprising a terminal carboxylic acid group, wherein the capping group comprises in total at least six carbon atoms.

Abstract: Described are amphiphilic polymers that are provided with chelating moieties. The amphiphilic polymers are block copolymers comprising a hydrophilic block and a hydrophobic block, with the chelating moieties linked to the end-group of the hydrophilic block. The disclosed polymers are capable of self-assembly into structures such as micelles and polymersomes. With suitable metals present in the form of coordination complexes with the chelating moieties, the chelating amphiphilic polymers of the invention are suitable for use in various imaging techniques requiring metal labeling, such as MRI (T1/T2 weighted contrast agents or CEST contrast agents) SPECT, PET or Spectral CT.

Abstract: The invention provides a lighting device (1) comprising (a) a light source (10) configured to generate light source light (11), and (b) a light converter (100) configured to convert at least part of the light source light (11) into visible converter light (111), wherein the light converter (100) comprises a matrix (120) containing a luminescent material (140) based on derivatives of benzimidazoxanthenoisoquinolinone. The lighting device may further comprise a further luminescent material (130).

Abstract: Disclosed are carriers for drugs and/or MR imaging agents having a lipid bilayer shell comprising a phospholipid having two terminal alkyl chains, one being a short chain having a chain length of at most seven carbon atoms, the other being a long chain having a chain length of at least fifteen carbon atoms. The mixed long/short chain phospholipids serve to tune the release properties of the carrier. Preferred phospholipids are phosphatidylcholines.

Abstract: The invention provides a light-emitting arrangement (100) comprising a light source (105) adapted to emit light of a first wavelength, and a wavelength converting member (106) arranged to receive light of said first wavelength and adapted to convert at least part of the light of said first wavelength to light of a second wavelength, said wavelength converting member comprising i) a carrier polymeric material comprising a polyester backbone comprising an aromatic moiety, and ii) at least one wavelength converting material of a specified general formula. The perylene derived compounds have been found to have excellent stability when incorporated into said matrix material.

Abstract: A system for providing an oral care agent includes a first layer containing the oral care agent and a second layer. The first layer can be applied directly to teeth. The second layer can subsequently be applied onto the first layer to inhibit leakage of the oral care agent outwards into the mouth.

Abstract: Described is a pretargeting method, and related kits, for targeted medical imaging and/or therapeutics, wherein use is made of abiotic reactive chemical groups that exhibit bio-orthogonal reactivity towards each other. The invention involves the use of [4+2] inverse electron demand (retro) Diels-Alder chemistry in providing the coupling between a Pre-targeting Probe and an Effector Probe. To this end one of these probes comprises an electron-deficient tetrazine or other suitable diene, and the other an E-cyclooctene which has one or more axial substituents.

Abstract: The invention provides a lighting device (1) comprising (a) a light source (10) configured to generate light source light (11), and (b) a light converter (100) configured to convert at least part of the light source light (11) into visible converter light (111), wherein the light converter (100) comprises a matrix (120) containing a luminescent material (140) based on derivatives of benzimidazoxanthenoisoquinolinone. The lighting device may further comprise a further luminescent material (130).

Abstract: The invention provides a light-emitting arrangement (100) comprising a light source (105) adapted to emit light of a first wavelength, and a wavelength converting member (106) arranged to receive light of said first wavelength and adapted to convert at least part of the light of said first wavelength to light of a second wavelength, said wavelength converting member comprising i) a carrier polymeric material comprising a polyester backbone comprising an aromatic moiety, and ii) at least one wavelength converting material of a specified general formula. The perylene derived compounds have been found to have excellent stability when incorporated into said matrix material.

Abstract: The invention provides a light-emitting arrangement (100) comprising a light source (105) adapted to emit light of a first wavelength, and a wavelength converting member (106) arranged to receive light of said first wavelength and adapted to convert at least part of the light of said first wavelength to light of a second wavelength, said wavelength converting member comprising i) a carrier polymeric material comprising a polyester backbone comprising an aromatic moiety, and ii) at least one wavelength converting material of a specified general formula. The perylene derived compounds have been found to have excellent stability when incorporated into said matrix material.

Abstract: The invention provides a lighting device (1) comprising (a) a light source (10) configured to generate light source light (11), and (b) a light converter (100) configured to convert at least part of the light source light (11) into visible converter light (111), wherein the light converter (100) comprises a matrix (120) containing an organic luminescent material (140) of the benzoxanthene derivative type. The lighting device may further comprise a further luminescent material (130).

Abstract: The invention provides a lighting device (1) comprising (a) a light source (10) configured to generate light source light (11), and (b) a light converter (100) configured to convert at least part of the light source light (11) into visible converter light (111), wherein the light converter (100) comprises a matrix (120) containing an organic luminescent material (140) of the perylene type. The lighting device may further comprise an inorganic luminescent material (130).