Abstract: Provided herein are antibodies and antibody compositions. Also provided are method for obtaining such antibodies and methods for using such antibodies and compositions for treating bacterial and viral infections and for research and screening purposes. The antibodies and compositions can affect the immune system and inhibiting pathogenic infections including streptococcal infections.

Abstract: The invention relates to a method for the determination of an MRM or SRM assay for a protein of interest, a peptide of interest, or a group of proteins/peptides of interest or a whole proteome. It essentially includes the following steps: (1) a list of proteins of interest is selected and for each member at least one or a list of candidate proteotypic peptides is derived (2) this at least one peptide is synthesized/generated essentially without subsequent purification; (3) this at least one unpurified peptide is analyzed by selected reaction monitoring (SRM) preferably coupled to liquid chromatography (LC-SRM) or analogous techniques; (4) validation and/or optimisation of the corresponding assay of the at least one peptide with determination of the SRM coordinates for a peptide/protein of interest and/or of a regulator of interest is achieved.

Abstract: Method for processing digital image data for a two-dimensional array of sample substance spots and marker substance spots in an electrophoresis gel by using landmark substances having predefined properties, comprising the steps of:generating an ideal image represented by co-ordinate data corresponding to ideal positions of the marker substance spots in said array dependent on electrophoresis conditions; generating a marker image represented by co-ordinate data corresponding to detected positions of said marker substances spots in the array; determining a mathematical relation between the ideal image and the marker image, such that the co-ordinate data of said images are mapped onto each other; generating a sample image represented by a sample image data set corresponding to detected signal values in the gel; and normalising the sample image by transforming it dependent on said mathematical relation.

Abstract: Marker compounds suitable for gel electrophoresis are disclosed. The compounds are natural, non-natural compounds or a mixture thereof, but not a protein. The compounds comprise at least one monomer unit, at least one functional group unit and optionally at least one core unit. Also contemplated is a method for positioning the marker compounds or a set of the compounds according to the invention and a method for the detection and/or quantification of s sample molecule in a two-dimensional gel.