Abstract: Described are proteinaceous molecules comprising at least two, preferably three to six, binding domains that bind specifically to at least two different binding sites on aberrant cells. These multi-domain and multi-specific binding molecules are preferably used in selectively modulating biological processes. The provided binding molecules are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers and autoimmune diseases.

Abstract: An electrical connector is provided. The electrical connector includes a first mounting portion. The electrical connector further includes a first clamping portion coupled to the first mounting portion. The first clamping portion has a first coupling tab and a second coupling tab. The first and second coupling tabs define a first gap. The first and second coupling tabs are configured to form an electrical connection with the first busbar in the first gap.

Abstract: A door hinge includes a hinge body, a hinge pin, and a hinge base. The hinge body includes a first channel that defines a first axis, the hinge body further includes a slot formed therethrough at an angle to the first axis, and the hinge body further includes a retention apparatus arranged within the slot. The hinge pin is operatively disposed in the first channel and configured to travel along the first axis, the hinge pin includes at least three retention formations formed thereon, a first retention formation defines a first retention position, a second retention formation defines a second retention position, a third retention formation defines a third retention position, and the retention apparatus is configured to engage the hinge pin at one of the at least three retention formations. The hinge base includes a second channel configured to operatively receive at least a portion of the hinge pin.

Abstract: A frame for an enclosure includes a first set of corner support structures. Each corner support structure of the first set of corner support structures includes a main body, a first protrusion arranged to extend from the main body, a second protrusion arranged to extend from the main body and substantially orthogonal to the first protrusion, and a third protrusion arranged to extend from the main body and substantially orthogonal to both the first protrusion and the second protrusion. The frame further includes a second set of corner support structures having mirror image symmetry about a plane of symmetry of an opposing corner support structure of the first set of corner support structures.

Abstract: A door hinge includes a hinge body, a hinge pin, and a hinge base. The hinge body includes a first channel that defines a first axis, the hinge body further includes a slot formed therethrough at an angle to the first axis, and the hinge body further includes a retention apparatus arranged within the slot. The hinge pin is operatively disposed in the first channel and configured to travel along the first axis, the hinge pin includes at least three retention formations formed thereon, a first retention formation defines a first retention position, a second retention formation defines a second retention position, a third retention formation defines a third retention position, and the retention apparatus is configured to engage the hinge pin at one of the at least three retention formations. The hinge base includes a second channel configured to operatively receive at least a portion of the hinge pin.

Abstract: Described are immunoglobulins provided with a toxic moiety, comprising at least an immunoglobulin variable region that specifically binds to an MHC-peptide complex preferentially associated with aberrant cells. These immunoglobulins provided with a toxic moiety are preferably used in selectively modulating biological processes. The provided immunoglobulins provided with a toxic moiety are of particular use in pharmaceutical compositions for the treatment of diseases related to cellular aberrancies, such as cancers and autoimmune diseases.

Abstract: An electrical connector is provided. The electrical connector includes a first mounting portion. The electrical connector further includes a first clamping portion coupled to the first mounting portion. The first clamping portion has a first coupling tab and a second coupling tab. The first and second coupling tabs define a first gap. The first and second coupling tabs are configured to form an electrical connection with the first busbar in the first gap.

Abstract: Described is a computerized system for offering financing to applicants seeking financing for the purchase of real estate. The system comprises gathering information from the applicants regarding the applicants and the real estate; calculating, with computerized software, a separation insurance policy premium for the applicants based upon this and other information; determining the insurance policy price with the mortgage financing; offering the mortgage financing, coupled with the insurance premium, to the applicants; if the applicants accept, entering into a legally binding agreement memorializing the separation insurance policy; periodically and regularly charging the calculated periodic amount to the applicants; and administering the separation insurance in such a manner that, upon divorce or legal separation of the applicants, payments are made on behalf of the applicants for the real estate.

Abstract: Described is a system for offering financing to a couple seeking financing for the purchase of real estate, the improvement comprising gathering information from the couple regarding the couple and the piece of residential real estate; calculating, with computerized software, a divorce insurance policy premium for the couple based upon this and other information; determining the insurance policy premium's price with the mortgage financing; offering the mortgage financing, coupled with the insurance premium, to the couple; if the couple accepts, creating a legally binding document memorializing the mortgage insurance policy, wherein the legally binding document sets forth terms and conditions of the mortgage insurance policy; transmitting the completed, legally binding document to the couple; periodically and regularly charging the calculated periodic amount to the couple; and administering the mortgage insurance policy in such a manner that, upon divorce or legal separation of the couple, paying damages arisi

Abstract: An inhaler for delivering dry-powder medicament to a patient from an open blister pocket of a blister pack. The inhaler includes a housing for enclosing used and unused portions of the blister pack together with a medicament dispensing mechanism. The inhaler also includes a manifold through which air can be drawn in use of the inhaler, the manifold including an air inlet for receiving external air, at least one medicament aperture for communicating with an opened pocket of the blister pack to enable entrainment of the medicament by the air drawn through the manifold, and an air outlet for delivery of the entrained medicament to the patient. The medicament dispensing mechanism includes a guide surface for guiding the cover sheet of the unused portion of the blister pack. The manifold and the guide surface are defined by separate components of the inhaler.

Abstract: An inhaler for delivering dry-powder medicament to a patient from an open blister pocket of a blister pack. The blister pack is in the form of a flexible elongate strip including a base sheet having a plurality of recesses spaced along its length and a cover sheet peelably sealed to the base sheet to define a plurality of blister pockets each containing a measured dose of the medicament. The inhaler also includes a housing for enclosing used and unused portions of the blister pack together with the medicament dispensing mechanism. The housing defines internal transverse walls extending in the width direction of the blister pack for isolating the used portion of the cover sheet from the unused portion of the blister pack.

Abstract: Described are methods for testing at least one effect of a pharmaceutical substance in a subject, which include administering a pharmaceutical substance to the subject, measuring with at least one sensor contained within a mobile sensor system, at the subject or in close proximity to the subject, at least one parameter value indicative of a the subject's body function, transmitting at least one sensor system signal associated with the at least one parameter value to a receiver contained within a mobile base unit, the receiver being provided with a means for wireless transmission, and wirelessly transmitting a mobile base unit signal associated with the at least one sensor system signal from the receiver to a back-end system, wherein at least the back-end system correlates the at least one parameter value with and/or displays a representation of the at least one effect of the pharmaceutical substance.

Abstract: An inhaler for delivering dry-powder medicament to a patient from an open blister pocket of a blister pack. The blister pack has a plurality of blister pockets spaced apart in a length direction of the pack and each containing a measured dose of the medicament. The inhaler includes a housing for enclosing used and unused portions of the blister pack together with a medicament dispensing mechanism for opening the blister pockets of the blister pack. The inhaler also includes a manifold through which air can be drawn in use of the inhaler, the manifold including an air inlet for receiving external air, at least one medicament aperture for communicating with an opened pocket of the blister pack to enable entrainment of the medicament by the air drawn through the manifold, and an air outlet for delivery of the entrained medicament to the patient.

Abstract: An inhaler for delivering dry-powder medicament to a patient from an open blister pocket of a blister pack. The inhaler includes a housing for enclosing used and unused portions of the blister pack together with a medicament dispensing mechanism. The inhaler also includes a manifold through which air can be drawn in use of the inhaler, the manifold including an air inlet for receiving external air, at least one medicament aperture for communicating with an opened pocket of the blister pack to enable entrainment of the medicament by the air drawn through the manifold, and an air outlet for delivery of the entrained medicament to the patient. The medicament dispensing mechanism includes a guide surface for guiding the cover sheet of the unused portion of the blister pack. The manifold and the guide surface are defined by separate components of the inhaler.

Abstract: The invention provides means and methods for producing and/or selecting immunogenic compositions, comprising providing said composition with at least one epitope for a B-cell receptor and/or at least one epitope for a T-cell receptor, coupled to a protein that comprises at least one crossbeta structure, and testing at least one immunogenic property.

Abstract: The invention provides means and methods for producing and/or selecting immunogenic compositions, comprising providing said composition with at least one crossbeta structure and testing at least one immunogenic property.

Abstract: The invention provides means and methods for producing and/or selecting immunogenic compositions capable of activating a T-cell and/or a T-cell response, comprising providing said composition with at least one crossbeta structure and testing at least one immunogenic property.

Abstract: Provided is means and methods for producing and/or selecting immunogenic compositions capable of activating a T-cell and/or a T-cell response, comprising providing the composition with at least one cross-beta structure and testing at least one immunogenic property.

Abstract: Described are means and methods for producing and/or selecting immunogenic compositions, comprising providing the composition with at least one cross-beta structure and testing at least one immunogenic property.

Abstract: The invention includes a method of labeling a biological polymer involving including within the polymer a series of monomers that encode a source of origin or other useful information regarding the biological polymer. Preferably, the biological polymer is DNA, and the series of monomers spell the name of the entity creating the biological polymer using the single letter codes of amino acids corresponding to codons encoded by the DNA.