Abstract: An intravascular data analysis system to assess a blood vessel includes: an interface system configured to receive intravascular pressure data including a plurality of distal pressure (Pd) values measured by an intravascular data collection probe and a plurality of proximal pressure (Pa) values; a display system; one or more memory storage devices includes instructions; and a processor in communication with the interface system, the display system, and the one or more memory storage devices. The processor is configured to execute the instructions to: determine a plurality of Pd/Pa ratios based on the plurality of distal pressure (Pd) values and the plurality of proximal pressure (Pa) values, filter the plurality of Pd/Pa ratios using a filter having a time constant TC in a range of 1% to 50% of a heart cycle length, and control the display system to generate a plot based on the plurality of Pd/Pa ratios.

Abstract: A method of determining one or more diagnostic metrics to assess a blood vessel using intravascular data includes: sampling a sensor of an intravascular data collection probe disposed in the blood vessel during a pullback of the intravascular data collection probe through the blood vessel to obtain sampled distal pressure (Pd) values; receiving, at an intravascular data processing system, the sampled distal pressure (Pd) values and proximal pressure (Pa) values; determining sets of Pd/Pa ratios, each set including Pd/Pa ratios that are determined through an entirety of one heart cycle; determining minimum Pd/Pa ratios, each of which is a minimum within one of the sets of Pd/Pa ratios over the entirety of the corresponding heart cycle; and controlling a display system to generate a plot of a moving average of the minimum Pd/Pa ratios over time during the pullback.

Abstract: A method of determining one or more diagnostic metrics to assess a blood vessel using intravascular data includes: sampling a sensor of an intravascular data collection probe disposed in the blood vessel during a pullback of the intravascular data collection probe through the blood vessel to obtain sampled distal pressure (Pd) values; receiving, at an intravascular data processing system, the sampled distal pressure (Pd) values and proximal pressure (Pa) values; determining sets of Pd/Pa ratios, each set including Pd/Pa ratios that are determined through an entirety of one heart cycle; determining minimum Pd/Pa ratios, each of which is a minimum within one of the sets of Pd/Pa ratios over the entirety of the corresponding heart cycle; and controlling a display system to generate a plot of a moving average of the minimum Pd/Pa ratios over time during the pullback.

Abstract: In part, the disclosure relates to computer-based methods, and systems suitable for evaluating a cardiac system using a diagnostic metric such as a pressure value-based ratio. Selection of a subset or portion of a cardiac cycle is avoided in one embodiment to increase reliability and usability of a diagnostic ratio and parameters described herein. In one embodiment, a minimum or a relative extrema of a series of diagnostic metrics plotted on a per cycle basis are used to inform diagnosis of a stenosis or other intravascular event or phenomena.

Abstract: In part, the disclosure relates to computer-based methods, and systems suitable for evaluating a subject to determine the appropriate diagnostic tools for assessing coronary arteries. This can include assessing various blood pressure values during a resting state (without inducing hyperemia). These systems and methods can assess a patient and identify coronary dominance on per patient basis. In turn, this assessment can be used to recommend whether a resting index is appropriate or if another index such as FFR or others such be obtained diagnostic metric such as a pressure value-based ratio.

Abstract: In part, the invention relates to an image data collection system. The system can include an interferometer having a reference arm that includes a first optical fiber of length of L1 and a sample arm that includes a second optical fiber of length of L2 and a first rotary coupler configured to interface with an optical tomography imaging probe, wherein the rotary coupler is in optical communication with the sample arm. In one embodiment, L2 is greater than about 5 meters. The first optical fiber and the second optical fiber can both be disposed in a common protective sheath. In one embodiment, the system further includes an optical element configured to adjust the optical path length of the reference arm, wherein the optical element is in optical communication with the reference arm and wherein the optical element is transmissive or reflective.

Abstract: In part, the invention relates to an image data collection system. The system can include an interferometer having a reference arm that includes a first optical fiber of length of L1 and a sample arm that includes a second optical fiber of length of L2 and a first rotary coupler configured to interface with an optical tomography imaging probe, wherein the rotary coupler is in optical communication with the sample arm. In one embodiment, L2 is greater than about 5 meters. The first optical fiber and the second optical fiber can both be disposed in a common protective sheath. In one embodiment, the system further includes an optical element configured to adjust the optical path length of the reference arm, wherein the optical element is in optical communication with the reference arm and wherein the optical element is transmissive or reflective.

Abstract: In part, the invention relates to an image data collection system. The system can include an interferometer having a reference arm that includes a first optical fiber of length of L1 and a sample arm that includes a second optical fiber of length of L2 and a first rotary coupler configured to interface with an optical tomography imaging probe, wherein the rotary coupler is in optical communication with the sample arm. In one embodiment, L2 is greater than about 5 meters. The first optical fiber and the second optical fiber can both be disposed in a common protective sheath. In one embodiment, the system further includes an optical element configured to adjust the optical path length of the reference arm, wherein the optical element is in optical communication with the reference arm and wherein the optical element is transmissive or reflective.

Abstract: In part, the disclosure relates to computer-based methods, and systems suitable for evaluating a cardiac system using a diagnostic metric such as a pressure value-based ratio. Selection of a subset or portion of a cardiac cycle is avoided in one embodiment to increase reliability and usability of a diagnostic ratio and parameters described herein. In one embodiment, a minimum or a relative extrema of a series of diagnostic metrics plotted on a per cycle basis are used to inform diagnosis of a stenosis or other intravascular event or phenomena.

Abstract: In part, the invention relates to an image data collection system. The system can include an interferometer having a reference arm that includes a first optical fiber of length of L1 and a sample arm that includes a second optical fiber of length of L2 and a first rotary coupler configured to interface with an optical tomography imaging probe, wherein the rotary coupler is in optical communication with the sample arm. In one embodiment, L2 is greater than about 5 meters. The first optical fiber and the second optical fiber can both be disposed in a common protective sheath. In one embodiment, the system further includes an optical element configured to adjust the optical path length of the reference arm, wherein the optical element is in optical communication with the reference arm and wherein the optical element is transmissive or reflective.

Abstract: Pressure measurement device (2) including a pressure sensor (6) adapted to perform pressure measurements in the left ventricle of a heart (8). The sensor is connected to a measurement unit (10) to receive pressure measurement values obtained from the sensor, and to a processing means (12) for determining a set of pressure values, said processing means then determines a set of first order time derivative values determined from the set of pressure values.

Abstract: Pressure measurement device (2) including a pressure sensor (6) adapted to perform pressure measurements in the left ventricle of a heart (8). The sensor is connected to a measurement unit (10) to receive pressure measurement values obtained from the sensor, and to a processing means (12) for determining a set of pressure values, said processing means then determines a set of first order time derivative values determined from the set of pressure values.

Abstract: Pressure measurement system, comprising a pressure detection device comprising a pressure sensor guidewire 5 provided with a pressure sensor connected to an electrical carrier for transmitting pressure data from the sensor to a processing means 1. The guidewire is adapted to be inserted into a vessel of a subject, and an image data capturing device for capturing image data representative of the vessel. The processing means 1 comprising a computer program product which comprises computer executable instructions for manipulating image data and pressure data to generate an output in which the pressure data is mapped onto a corresponding position on an image where that pressure data was detected to provide an integrated graphical image output on a monitoring means 2.

Abstract: A method to assist an operator of an interactive measurement system for determining flow related parameters based upon physiological signals obtained by a measurement unit that comprises a catheter adapted to be inserted into a vessel inside a body of a human or an animal, a wire adapted to be inserted into the catheter and provided with a temperature sensor at its distal end, and a computer means adapted to receive and store detected temperature signals received from said sensor and said wire.

Abstract: This invention relates to a method and system for monitoring, determining by measurement and calculation and graphically displaying physiological variables related to blood pressure. At least two physiological variables, arterial pressure (Pa) and distal coronary pressure (Pd), are detected by and derived from a guidewire-mounted pressure sensor. The Myocordial Fractional Flow Reserve (FFRmyo) is determined by calculating a ratio Pd/Pa from the measured physiological variables (Pa, Pd) and a graph is formed and displayed of the data resulting from the calculation. The invention also provides an interactive graphical user interface system for controlling the calculation of and for displaying, in at least one screen on a display in a monitoring unit, intermediate and final results of the method.

Abstract: A method to assist an operator of an interactive measurement system for determining flow related parameters based upon physiological signals obtained by a measurement unit that comprises a catheter adapted to be inserted into a vessel inside a body of a human or an animal, a wire adapted to be inserted into the catheter and provided with a temperature sensor at its distal end, and a computer means adapted to receive and store detected temperature signals received from said sensor and said wire.

Abstract: This invention relates to a method and system for monitoring, determining by measurement and calculation and graphically displaying physiological variables related to blood pressure, wherein at least two physiological variables, arterial pressure (Pa) and distal coronary pressure (Pd), is detected by and derived from a guidewire-mounted pressure sensor. The Myocordial Fractional Flow Reserve (FFRmyo) is determined by calculating a ratio Pd/Pa from said measured physiological variables (Pa, Pd) and a graph is formed and displayed of the data resulting from said calculation. The invention also provides an Interactive graphical User Interface system for controlling the performance of and for displaying, in at least one screen on a display in a monitoring unit, intermediate and final results of said invented method.