Abstract: The present invention relates to a method of obtaining 68Ga from a 68Ge/68Ga radioisotope generator and a method of preparing 68Ga-radiolabelled complexes using the obtained 68Ga. The method comprises elution of the generator with an aqueous chloride ion solution. The invention further relates to an apparatus for carrying out the 68Ga metal complex formation.

Abstract: A micro vial assembly for performing microwave-assisted chemical reactions on small reaction mixture volumes is disclosed, wherein a reaction vessel (10) is sealed through a diaphragm (30) that is capped over an open end of the reaction vessel. The reaction vessel mouths in an end plane of a sleeve (20) surrounding the reaction vessel, the diaphragm being clamped for sealing the open end of the vessel by means of a cap (40) which is secured to the sleeve. The sleeve provides a radial extension of the reaction vessel in order to bridge the radial distance between a wall of the reaction vessel and other components in a system for performing microwave-assisted chemical reactions.

Abstract: A method of producing [18F]F2 from [18F] fluoride through a plasma induced scrambling procedure is provided. The present invention also provides an apparatus for preparing [18F]F2 from [18F] fluoride in a plasma induced scrambling procedure. Kit claims for preparing [18F]F2 from [18F] fluoride in a plasma induced scrambling procedure as well as method of use and use of claims for preparing [18F]F2 from [18F] fluoride through a plasma induced scrambling procedure are also provided.

Abstract: The present invention relates to a method of obtaining 68Ga from a 68Ge/68Ga radioisotope generator and a method of preparing 68Ga-radiolabelled complexes using the obtained 68Ga. The method comprises elution of the generator with an aqueous chloride ion solution. The invention further relates to an apparatus for carrying out the 68Ga metal complex formation.

Abstract: The invention relates to a synthetic strategy of using perfluoro crown ethers and other macrocycles to bind to [18F]-labelled fluorination reactions. The optional use of implementing perfluoro kryptofix 2.2.2 in this process is also disclosed. The present invention also claims perfluoro kryptofix structures that are suitable for use in 18F-labelling of fluorous based structures.

Abstract: A method of producing [18F]F2 from [18F] fluoride through a plasma induced scrambling procedure is provided. The present invention also provides an apparatus for preparing [18F]F2 from [18F] fluoride in a plasma induced scrambling procedure. Kit claims for preparing [18F]F2 from [18F] fluoride in a plasma induced scrambling procedure as well as method of use and use of claims for preparing [18F]F2 from [18F] fluoride through a plasma induced scrambling procedure are also provided.

Abstract: A method and an apparatus for preparing [11C]methyl iodide from [11C]methane and iodine in a single pass through a non-thermal plasma reactor has been developed. The plasma was created by applying high voltage (400 V/31 kHz) to electrodes in a stream of helium gas at reduced pressure. The [11C]methane used in the experiments was produced from [11C]carbon dioxide via reduction with hydrogen over nickel. [11C]Methyl iodide was obtained with a specific radioactivity of 412±32 GBq/?mol within 6 min from approximately 24 GBq of [11C]carbon dioxide. The decay corrected radiochemical yield was 13±3% based on [11C]carbon dioxide at start of synthesis. [11C]Flumazenil was synthesized via a N-alkylation with the prepared [11C]methyl iodide. Kit and apparatus for preparing [11C]methyl iodide by a non thermal plasma method are also provided.

Abstract: A micro vial assembly for performing microwave-assisted chemical reactions on small reaction mixture volumes is disclosed, wherein a reaction vessel (10) is sealed through a diaphragm (30) that is capped over an open end of the reaction vessel. The reaction vessel mouths in an end plane of a sleeve (20) surrounding the reaction vessel, the diaphragm being clamped for sealing the open end of the vessel by means of a cap (40) which is secured to the sleeve. The sleeve provides a radial extension of the reaction vessel in order to bridge the radial distance between a wall of the reaction vessel and other components in a system for performing microwave-assisted chemical reactions.

Abstract: The present invention discloses a method and an apparatus for high yield production of .sup.11 C-methyl iodide by selectively monohalogenating .sup.11 C-methane, whereby the method is comprising a first step of introducing .sup.11 CH.sub.4 into an apparatus containing a circulation system comprising a number of connected circulation members (1-7), and the circulation system is further comprising a number of valves (V114 V5) and at least one pump (8) for controlling the circulation. The method further comprises a second step of recirculation of .sup.11 CH.sub.4 and introduction of iodine vapor into the circulating gas stream passed through a heated reaction chamber (3) within the apparatus having the circulation system during a predefined time period during continuous removal of formed .sup.11 CH.sub.3 I by means of a second trap (7), and a third step of releasing after the predefined time period the produced .sup.

Abstract: A method is provided for preparing [.sup.18 F]2-fluoro-2-deoxyglucose with an anion exchange resin by effecting an exchange reaction between an aqueous solution of [.sup.18 F]fluoride containing an alkali metal carbonate or bicarbonate, such as sodium bicarbonate, and an anion, such as bicarbonate or carbonate, on the anion exchange resin followed by the displacement reaction with 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-.beta.-D-mannopyranose to form the resulting 2-fluoro-2-deoxyglucose tetraacetate. Improved yields of the [.sup.18 F]2-fluoro-2-deoxyglucose are obtained when the alkali bicarbonate or carbonate is used in the target water.