Abstract: The present invention relates to systems and methods for screening compounds and/or mutant ribosomal proteins in a eukaryotic cell that increase or decrease the translation of a target gene and thereby ameliorate or revert a defective and/or undesired translation of a target gene. Disclosed are compounds and proteins as identified with the methods and systems of the invention, pharmaceutical and cosmetic compositions thereof, their uses for the preparation of a medicament, methods of treatment of a disease or condition or cosmetic condition related to the defective translation of a gene, for example genetic diseases such as Epidermolysis bullosa, as well as diagnostic measures practical for the clinical evaluation of such diseases or conditions.

Abstract: The invention relates to a method for the thermal control of at least one temperature-dependent enzymatic reaction in the presence of magnetic particles, particularly nanoparticles, or magnetic beads in vitro by means of the heating of the magnetic beads or magnetic particles to at least one certain target temperature by means of alternating magnetic fields. The enzymatic reaction which can be controlled with the method according to the invention is preferably a PCR reaction or another reaction for the elongation or amplification of nucleic acids, including DNA, RNA or hybrids or derivatives thereof, which takes place directly on the functionalized magnetic beads. Further aspects of the invention relate to a reactor for carrying out the method and the use of the method or the reactor in analytics and diagnostics.

Abstract: The present invention relates to a pharmaceutical composition which includes naturally occurring, non-transgenic isolated bacteria from the group of Lactococcus and Acinetobacter or fragments thereof or mixtures thereof, to such a bacterium as a medicament for the prevention and/or treatment of allergic or chronic inflammatory disorders and to a process for producing this composition.

Abstract: The invention relates to a brake disc for a disc brake, in particular in motor vehicles. Said brake disc comprises a friction ring (12) and a pot-shaped supporting part (14), the friction ring consisting of several ring segments (18), which adjoin one another in a circumferential direction. To provide a construction that can be commercially produced in a cost-effective manner and that is not prone to warping, the ring segments are provided with semi-circular recesses (18a), which encompass retaining bolts (16) that extend radially. The retaining bolts are fixed in circumferential sections of the supporting part and support the ring segments by means of a positive fit in a centrifugal direction. The retaining bolts are preferably configured in a tubular manner.

Abstract: The invention relates to an electromagnetic switching device, in particular a contactor, comprising a switching device housing (2) and a plug-in module which can be inserted into the latter and which contains a coil form (12) for a coil. A tripping element (60) is mounted on a housing section (40) of the plug-in module (4). Said element is designed to mechanically actuate the contact unit (30) of an electric switch (24) for producing an economy connection. The switch (24) is mounted on a support structure (printed-circuit board (22)) that is located in the plug-in module (4), with a supporting contour (70) of said switch adjoining a bearing contour (72) of the housing section (40).

Abstract: The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosomal mediated RNA trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and mediate a trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA). In particular, the PTMs of the present invention can be genetically engineered to interact with a specific target pre-mRNA expressed in cells of the skin so as to result in correction of genetic defects responsible for a variety of different skin disorders to encode a reporter molecule or protein that may have therapeutic benefit. The compositions of the invention further include recombinant vectors systems capable of expressing the PTMs of the invention and cells expressing said PTMs.

Abstract: The invention relates to a brake disc for a disc brake, in particular in motor vehicles. Said brake disc comprises a friction ring (12) and a pot-shaped supporting part (14), the friction ring consisting of several ring segments (18), which adjoin one another in a circumferential direction. To provide a construction that can be commercially produced in a cost-effective manner and that is not prone to warping, the ring segments are provided with semi-circular recesses (18a), which encompass retaining bolts (16) that extend radially. The retaining bolts are fixed in circumferential sections of the supporting part and support the ring segments by means of a positive fit in a centrifugal direction. The retaining bolts are preferably configured in a tubular manner.

Abstract: An electromagnetic switching device, especially a contactor, includes a base, an arc chamber removable from the base, a contact bridge support and a spring-loaded locking element. The contact bridge support projects into the arc chamber and can be displaced in a direction of actuation. The contact bridge support can be locked by the locking element when the arc chamber is taken off. The locking element is configured as a lever that is swiveled about a swiveling axis which extends in perpendicular to the direction of actuation.

Abstract: The present invention provides methods and compositions for generating novel nucleic acid molecules through targeted spliceosomal mediated RNA trans-splicing. The compositions of the invention include pre-trans-splicing molecules (PTMs) designed to interact with a target precursor messenger RNA molecule (target pre-mRNA) and mediate a trans-splicing reaction resulting in the generation of a novel chimeric RNA molecule (chimeric RNA). In particular, the PTMs of the present invention are genetically engineered to interact with a specific target pre-mRNA expressed in cells of the skin so as to result in correction of genetic defects responsible for a variety of different skin disorders. The compositions of the invention further include recombinant vectors systems capable of expressing the PTMs of the invention and cells expressing said PTMs.

Abstract: A vacuum contactor includes a stationary contact and a moving contact, which can be moved in order to produce a current-carrying connection. In order to guide the moving contact during its movement in the enclosure, at least one guide element, which can be moved in a groove, is provided on the moving contact.

Abstract: An electromagnetic switching device includes a housing and a plug-in module which can be inserted into the housing at an insertion point in a direction of insertion. The plug-in module holds a magnetic yoke, attached to which is a coil unit. Two extensions, which point respectively to the front and to the rear in relation to the direction of insertion, are formed on the magnetic yoke. In order to retain the magnetic yoke, a retaining bracket extending transversally in relation to the direction of insertion, overlaps one of the fixing extensions and engages two retaining tongues from below, said tongues being formed as one-piece with the plug-in module.

Abstract: The invention relates to an electromagnetic switching device, especially a contactor, comprising a base (1), an arc chamber (2) removable from the base (1), a contact bridge support (4) and a spring-loaded locking element (5). The contact bridge support (4) projects into the arc chamber (2) and can be displaced in a direction of actuation (x). The contact bridge support can be locked by means of the locking element (5) when the arc chamber (2) is taken off. The locking element (5) is configured as a lever that is swiveled about a swiveling axis (10) which extends in perpendicular to the direction of actuation (x).

Abstract: The invention relates to an electromagnetic switching device comprising a housing (1) and a plug-in module (3) which can be inserted into the housing (1) at an insertion point (2) in a direction of insertion (x). The plug-in module (3) holds a magnetic yoke (4), attached to which is a coil unit (20). Two fixing extensions (7), which point respectively to the front and to the rear in relation to the direction of insertion (x), are formed on the magnetic yoke (4). In order to retain the magnetic yoke (4), a retaining bracket (13) extending transversally in relation to the direction of insertion (x), overlaps one of the fixing extensions (7) and engages two retaining tongues (15) from below, said tongues being formed as one-piece with the plug-in module (3).

Abstract: The invention relates to an electromagnetic switching device, in particular a contactor, comprising a switching device housing (2) and a plug-in module which can be inserted into the latter and which contains a coil form (12) for a coil. A tripping element (60) is mounted on a housing section (40) of the plug-in module (4). Said element is designed to mechanically actuate the contact unit (30) of an electric switch (24) for producing an economy connection. The switch (24) is mounted on a support structure (printed-circuit board (22)) that is located in the plug-in module (4), with a supporting contour (70) of said switch adjoining a bearing contour (72) of the housing section (40).

Abstract: A capacitor switching contactor is described which includes a standard contactor, an auxiliary switch, an input terminal block, an output terminal block, as well as resistance wires disposed between the terminal blocks, on the one hand, and the auxiliary switch, on the other hand. The resistance wires are connected to connecting terminals in chambers of the terminal blocks, and largely accommodated in the housing of the terminal blocks.

Abstract: For anchoring a prosthesis within a bone by means of a bone cement (32), prothesis shaft has a surface which is formed by the surfaces of a plurality of spheres (23 . . . 25) partially penetrating each other and having radii which decrease from the proximal towards the distal shaft end. The transitional zones between adjacent spheres (23 . . . 25) are concavely rounded. This shape is especially suited for use with a glass ionomer-type bone cement, because the shaft exerts substantially only compressive forces on the cement, whereas tensile and notch stresses, with respect to which this kind of cement exhibits little resistance, are largely avoided.

Abstract: An auxiliary switch hookup assembly in a motor contactor includes a slide member biased by a spring and forming a portion of the limiting wall for the reception of an auxiliary switch. The spring force exerted by the biasing spring can be greater than a total force exerted by restoring and contact compression springs of the motor contactor.

Abstract: A switchgear apparatus having three switching gaps with contacts arranged thereacross for connecting three-phase electrical power to a consumer. Apparatus is described whereby a selected one of the switching gaps closes earlier than the other switching gaps during a closing cycle of the switchgear, and opens later than the other switching gaps during an opening cycle of the switchgear. The contacts across the early closing and late opening gap experience only minimal contact burnoff, thereby permitting a substantially reduced volume of contact overlay material to be provided therefor. In addition, less expensive contact material may be utilized for this contact.

Abstract: A contact arrangement for electric switchgear is disclosed. The contact arrangement comprises a bifurcated offset contact bridge having two contact bridge parts, each of which is inserted into an opening in an actuating contact bridge carrier. Each contact bridge part rests on a first supporting surface of the opening. A spring retainer rests against the contact bridge and a compression spring is mounted between a second surface of the opening and the spring retainer. The spring retainer is guided in the contact bridge carrier against movement transverse to the direction of motion of the carrier. Each end of each contact bridge part is provided with a semicircular contact pad which, when the contact bridge parts are placed adjacent each other, form a bifurcated circular contact pad which engages with corresponding stationary contacts.