Patents by Inventor Johann Bauersachs
Johann Bauersachs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240189339Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: November 21, 2023Publication date: June 13, 2024Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20230028937Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: June 22, 2022Publication date: January 26, 2023Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20210113603Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: September 1, 2020Publication date: April 22, 2021Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20200069720Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: August 16, 2019Publication date: March 5, 2020Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 10434117Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: GrantFiled: June 22, 2018Date of Patent: October 8, 2019Assignee: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20180360866Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: June 22, 2018Publication date: December 20, 2018Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 10028974Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: GrantFiled: April 19, 2017Date of Patent: July 24, 2018Assignee: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20170304347Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: April 19, 2017Publication date: October 26, 2017Applicant: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 9663788Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: GrantFiled: November 20, 2015Date of Patent: May 30, 2017Assignee: Julius-Maximilans-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20160177302Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: November 20, 2015Publication date: June 23, 2016Inventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 9220722Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: GrantFiled: October 23, 2013Date of Patent: December 29, 2015Assignee: JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURGInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 8906870Abstract: The invention relates to microRNAs (miRNAs) for the diagnosis, prophylaxis and/or treatment of heart diseases. It relates in particular to SEQ ID No: 1 to SEQ ID No: 29 for the diagnosis, prophylaxis and/or treatment of heart diseases. In addition, the invention relates to the use of these sequences to produce a medicament for heart diseases and for the diagnosis thereof. Also encompassed are a method for the diagnosis of a heart disease, a kit and an expression vector comprising these sequences, a cell which contains the expression vector, and also a method for modulating a heart disease and a method for screening a pharmaceutically active compound for the treatment and/or prophylaxis of a heart disease.Type: GrantFiled: October 9, 2007Date of Patent: December 9, 2014Assignee: Julius-Maximilians-Universitaet WuerzbergInventors: Thomas Thum, Johann Bauersachs
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Publication number: 20140121264Abstract: In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: October 23, 2013Publication date: May 1, 2014Applicant: JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURGInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 8592389Abstract: In some embodiments, the present invention concerns antisense oligonucleotides against targets of miR-21. In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: GrantFiled: June 28, 2012Date of Patent: November 26, 2013Assignee: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20130018084Abstract: In some embodiments, the present invention concerns antisense oligonucleotides against targets of miR-21. In some embodiments, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions inhibit the activity of miR-21 for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: June 28, 2012Publication date: January 17, 2013Applicant: JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURGInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Patent number: 8236777Abstract: The present invention relates to a promoter region of a microRNA, the use of a microRNA, in particular miR-21, and related elements for the diagnosis and for the manufacture of a medicament for the treatment and/or prevention of fibrosis and/or fibrosis related diseases. Additionally, the invention concerns antisense oligonucleotides against targets of miR-21. A cell deficient for miR-21, the promoter region and targets of miR-21 and a knock-out organism thereof are also encompassed. Finally, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis.Type: GrantFiled: February 26, 2009Date of Patent: August 7, 2012Assignee: Julius-Maximilians-Universitat WurzburgInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20110071211Abstract: The present invention relates to a promoter region of a microRNA, the use of a microRNA, in particular miR-21, and related elements for the diagnosis and for the manufacture of a medicament for the treatment and/or prevention of fibrosis and/or fibrosis related diseases. Additionally, the invention concerns antisense oligonucleotides against targets of miR-21. A cell deficient for miR-21, the promoter region and targets of miR-21 and a knock-out organism thereof are also encompassed. Finally, the invention is directed to a method for diagnosing fibrosis and/or fibrosis related diseases and to a method for screening a pharmaceutically active compound for the treatment of fibrosis and/or fibrosis related diseases. The present invention further relates to compositions for use in the treatment, amelioration, and/or prevention of fibrosis. In certain embodiments, the compositions modulate the activity of a miRNA for the treatment, amelioration, and/or prevention of fibrosis.Type: ApplicationFiled: February 26, 2009Publication date: March 24, 2011Applicant: JULIUS MAXIMILIANS-UNIVERSITÄT WÜRZBURGInventors: Thomas Thum, Johann Bauersachs, Stefan Engelhardt, Carina Gross
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Publication number: 20100010073Abstract: The invention relates to microRNAs (miRNAs) for the diagnosis, prophylaxis and/or treatment of heart diseases. It relates in particular to SEQ ID No: 1 to SEQ ID No: 29 for the diagnosis, prophylaxis and/or treatment of heart diseases. In addition, the invention relates to the use of these sequences to produce a medicament for heart diseases and for the diagnosis thereof. Also encompassed are a method for the diagnosis of a heart disease, a kit and an expression vector comprising these sequences, a cell which contains the expression vector, and also a method for modulating a heart disease and a method for screening a pharmaceutically active compound for the treatment and/or prophylaxis of a heart disease.Type: ApplicationFiled: October 9, 2007Publication date: January 14, 2010Applicant: JULIUS-MAXIMILIANS-UNIVERSITÄT WÜRZBURGInventors: Thomas Thum, Johann Bauersachs