Abstract: The present invention refers to the gene cluster and genes comprised by the gene cluster which are involved in the biosynthesis of griselimycin and methylgriselimycin and to the use of the gene cluster, genes comprised thereby and proteins encoded thereby for the production of antibiotic agents.

Abstract: The present invention refers to the gene cluster and genes comprised by the gene cluster which are involved in the biosynthesis of griselimycin and methylgriselimycin and to the use of the gene cluster, genes comprised thereby and proteins encoded thereby for the production of antibiotic agents.

Abstract: The present invention relates to a method of screening for a modulator of endothelial NO synthase (eNOS) expression, a method of diagnosing a cardiovascular disease in a subject, the use of HEBP-1 for the identification of a medicament for preventing and/or treating a disease involving eNOS dysfunction, particularly a cardiovascular disease, the use of HEBP-1 for the detection of a component of eNOS signal transduction, and the use of HEBP1 for the regulation of eNOS promoter activity.

Abstract: The present invention relates to a method of screening for a modulator of endothelial NO synthase (eNOS) expression, a method of diagnosing a cardiovascular disease in a subject, the use of HEBP-1 for the identification of a medicament for preventing and/or treating a disease involving eNOS dysfunction, particularly a cardiovascular disease, the use of HEBP-1 for the detection of a component of eNOS signal transduction, and the use of HEBP1 for the regulation of eNOS promoter activity.

Abstract: The invention relates to a method for identifying a compound which stimulates or attenuates the activity of the G protein-coupled receptor mas-like 1.

Abstract: Embodiments of the present invention relate to methods for identifying compounds which modify the activity of the G protein-coupled receptor GPR45 like/GPR63, compositions useful for this method, and compounds identified by it.

Abstract: The invention relates to a method for identifying a compound which stimulates or attenuates the activity of the G protein-coupled receptor mas-like 1.

Abstract: The present invention relates to newly identified human EDG8 receptors, polynucleotides encoding this receptor, polypeptides encoded by such polynucleotides, the preparation and the use of such polynucleotides and polypeptides.

Abstract: The invention relates to a method for identifying a compound which stimulates or attenuates the activity of the G protein-coupled receptor mas-like 1.

Abstract: Embodiments of the present invention relate to methods for identifying compounds which modify the activity of the G protein-coupled receptor GPR45 like/GPR63, compositions useful for this method, and compounds identified by it.

Abstract: The present invention relates to newly identified human EDG8 receptors, polynucleotides encoding this receptor, polypeptides encoded by such polynucleotides, the preparation and the use of such polynucleotides and polypeptides.

Abstract: Provided herein is a novel and useful G-protein coupled receptor that is involved in signal transduction with respect to inflammation and physiological immunological response. Also provided are methods of using the receptor to screen for molecules that may modulate the activity of the receptor. Such molecules may readily have applications in treating a plethora of inflammation and immunological related diseases and disorders.

Abstract: Methods for identifying a ligand of a G protein-coupled receptor (GPCR), such as ligands of orphan GPCRs, are provided. The methods include providing at least one cell containing a G-alpha protein that couples to at least one GPCR. The at least one cell is transformed with a recombinant DNA including a nucleic acid encoding a GPCR and the nucleic acid is expressed. At least one chemical compound is contacted with the transformed at least one cell and a calcium sensitive-fluorescent dye to form a first mixture. The at least one chemical compound is also contacted with at least one untransformed cell and the calcium sensitive-fluorescent dye to form a second mixture. Fluorescence from the first and second mixtures is measured and compared to determine whether the at least one chemical compound is a ligand of the GPCR. Nucleotide sequences, amino acid sequences, vectors, cells, and pharmaceuticals thereof are provided.

Abstract: The present invention relates to newly identified human EDG8 receptors, polynucleotides encoding this receptor, polypeptides encoded by such polynucleotides, the preparation and the use of such polynucleotides and polypeptides.