Patents by Inventor Johann Kubicek

Johann Kubicek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200239871
    Abstract: The present invention relates to a method for selectively depleting animal nucleic acids from non-animal nucleic acids in a sample, which comprises animal cells and at least one further type of cells, selected from microbial cells and plant cells or a combination thereof, to a lysis solution A to be used in and to a kit to carry out said method as well as to the use of a particular silica membrane as both, a filtration matrix for separating essentially intact microbial and/or plant cells from lysed animal cells and an adsorption matrix for nucleic acids, in particular in a method according to the present invention.
    Type: Application
    Filed: April 14, 2020
    Publication date: July 30, 2020
    Inventors: Johann KUBICEK, Thorsten SINGER, Antje-Katrin SANDER, Eva HÄNSSLER, Dominic O'NEIL
  • Patent number: 10655122
    Abstract: The present invention relates to a method for selectively depleting animal nucleic acids from non-animal nucleic acids in a sample, which comprises animal cells and at least one further type of cells, selected from microbial cells and plant cells or a combination thereof, to a lysis solution A to be used in and to a kit to carry out said method as well as to the use of a particular silica membrane as both, a filtration matrix for separating essentially intact microbial and/or plant cells from lysed animal cells and an adsorption matrix for nucleic acids, in particular in a method according to the present invention.
    Type: Grant
    Filed: April 20, 2015
    Date of Patent: May 19, 2020
    Assignee: QIAGEN GMBH
    Inventors: Johann Kubicek, Thorsten Singer, Antje-Katrin Sander, Eva Hänssler, Dominic O'Neil
  • Patent number: 10227378
    Abstract: The present invention pertains to a method for loading a crystallization device and for manufacturing a crystallization device comprising multiple receptacles with a pre-defined amount of at least one matrix-forming compound capable of forming a crystallization matrix for a membrane protein, said method comprising the following steps: a) Modifying the state of aggregation of said at least one matrix-forming compound to a fluidic state which allows dispensing said at least one matrix-forming compound, and b) dispensing a defined amount of said at least one matrix-forming compound into at least one receptacle of the crystallization device, wherein said dispensed matrix-forming compound solidifies within said receptacle. Thereby prefilled crystallization devices are obtained which can be used as consumables in particular in automated crystallization processes. Also provided are protein crystallization methods using respectively prepared crystallization devices.
    Type: Grant
    Filed: May 2, 2016
    Date of Patent: March 12, 2019
    Assignees: CUBE BIOTECH GmbH, QIAGEN GmbH
    Inventors: Johann Kubicek, Frank Schaefer, Joerg Labahn, Georg Bueldt
  • Publication number: 20180142231
    Abstract: The present invention relates to a method for selectively depleting animal nucleic acids from non-animal nucleic acids in a sample, which comprises animal cells and at least one further type of cells, selected from microbial cells and plant cells or a combination thereof, to a lysis solution A to be used in and to a kit to carry out said method as well as to the use of a particular silica membrane as both, a filtration matrix for separating essentially intact microbial and/or plant cells from lysed animal cells and an adsorption matrix for nucleic acids, in particular in a method according to the present invention.
    Type: Application
    Filed: April 20, 2015
    Publication date: May 24, 2018
    Applicant: QIAGEN GmbH
    Inventors: Johann Kubicek, Thorsten Singer, Antje-Katrin Sander
  • Publication number: 20160318974
    Abstract: The present invention pertains to a method for loading a crystallization device and for manufacturing a crystallization device comprising multiple receptacles with a pre-defined amount of at least one matrix-forming compound capable of forming a crystallization matrix for a membrane protein, said method comprising the following steps: a) Modifying the state of aggregation of said at least one matrix-forming compound to a fluidic state which allows dispensing said at least one matrix-forming compound, and b) dispensing a defined amount of said at least one matrix-forming compound into at least one receptacle of the crystallization device, wherein said dispensed matrix-forming compound solidifies within said receptacle. Thereby prefilled crystallization devices are obtained which can be used as consumables in particular in automated crystallization processes. Also provided are protein crystallization methods using respectively prepared crystallization devices.
    Type: Application
    Filed: May 2, 2016
    Publication date: November 3, 2016
    Inventors: Johann KUBICEK, Frank SCHAEFER, Joerg LABAHN, Georg BUELDT
  • Patent number: 9352248
    Abstract: The present invention pertains to a method for loading a crystallization device and for manufacturing a crystallization device comprising multiple receptacles with a pre-defined amount of at least one matrix-forming compound capable of forming a crystallization matrix for a membrane protein, said method comprising the following steps: a) Modifying the state of aggregation of said at least one matrix-forming compound to a fluidic state which allows dispensing said at least one matrix-forming compound, and b) dispensing a defined amount of said at least one matrix-forming compound into at least one receptacle of the crystallization device, wherein said dispensed matrix-forming compound solidifies within said receptacle. Thereby, pre-filled crystallization devices are obtained which can be used as consumables in particular in automated crystallization processes. Also provided are protein crystallization methods using respectively prepared crystallization devices.
    Type: Grant
    Filed: September 28, 2009
    Date of Patent: May 31, 2016
    Assignees: QIAGEN GmbH, CUBE BIOTECH GmbH
    Inventors: Johann Kubicek, Frank Schaefer, Joerg Labahn, Georg Bueldt
  • Patent number: 8668878
    Abstract: The present invention relates to a reaction vessel for crystallization of a sample from a solution and a covering foil and an arrangement for mounting the covering foil.
    Type: Grant
    Filed: September 8, 2009
    Date of Patent: March 11, 2014
    Assignee: Qiagen GmbH
    Inventors: Johann Kubicek, Bert Jungheim, Rainer Dahlke
  • Publication number: 20120219472
    Abstract: The present invention relates to a reaction vessel for crystallization of a sample from a solution and a covering foil and an arrangement for mounting the covering foil.
    Type: Application
    Filed: September 8, 2009
    Publication date: August 30, 2012
    Inventors: Johann KUBICEK, Bert JUNGHEIM, Rainer DAHLKE
  • Publication number: 20110269941
    Abstract: The present invention pertains to a method for loading a crystallization device and for manufacturing a crystallization device comprising multiple receptacles with a pre-defined amount of at least one matrix-forming compound capable of forming a crystallization matrix for a membrane protein, said method comprising the following steps: a) Modifying the state of aggregation of said at least one matrix-forming compound to a fluidic state which allows dispensing said at least one matrix-forming compound, and b) dispensing a defined amount of said at least one matrix-forming compound into at least one receptacle of the crystallization device, wherein said dispensed matrix-forming compound solidifies within said receptacle. Thereby, pre-filled crystallization devices are obtained which can be used as consumables in particular in automated crystallization processes. Also provided are protein crystallization methods using respectively prepared crystallization devices.
    Type: Application
    Filed: September 28, 2009
    Publication date: November 3, 2011
    Inventors: Johann Kubicek, Frank Schaefer, Joerg Labahn, Georg Bueldt
  • Publication number: 20110229381
    Abstract: The present invention relates to a reaction vessel for crystallization of a sample from a solution and a covering foil and an arrangement for mounting the covering foil (FIG. 1).
    Type: Application
    Filed: September 8, 2009
    Publication date: September 22, 2011
    Inventors: Johann Kubicek, Bert Jungheim, Rainer Dahlke