Patents by Inventor Johann Then

Johann Then has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Preparation containing a combination of 5-methylisoxazole-4-carboxylic acid-(4-trifluoromethyl)-anilide and N-(4-trifluoromethylphenyl)2-cyano-3-hydroxycrotonic acid amide
    Patent number: 7071222
    Abstract: A solid composition comprising 5-methyl-4?-trifluoromethyl-4-isoxazole carboxanilide and N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonic acid amide, suitable for treatment of immunological and cancerous diseases.
    Type: Grant
    Filed: March 7, 1997
    Date of Patent: July 4, 2006
    Assignee: Sanofi-Aventis Deuschland GmbH
    Inventors: Robert Bartlett, Johann Then
  • PREPARATION CONTAINING A COMBINATION OF 5-METHYLISOXAZOLE-4- CARBOXYLIC ACID-(4-TRIFLUOROMETHYL)-ANILIDE AND N- (4-TRIFLUOROMETHYLPHENYL)2-CYANO-3-HYDROXYCROTONIC ACID AMIDE
    Publication number: 20020006945
    Abstract: Combination preparation, comprising 5-methyl-4′-trifluoromethyl-4-isoxazolecarboxanilide and N-(4-trifluoromethylphenyl)-2-cyano-3-hydroxycrotonamide
    Type: Application
    Filed: October 23, 1998
    Publication date: January 17, 2002
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: ROBERT BARTLETT, JOHANN THEN
  • Process for preparing L-tertiary-leucine and L-phosphinothricine by transamination
    Patent number: 5962281
    Abstract: L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: October 5, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Johann Then, Klaus Bartsch, Hans-Matthias Deger, Susanne Grabley, Rudiger Marquardt
  • Process for preparing L-tertiary-leucine and L-phosphinothricine by transamination
    Patent number: 5919669
    Abstract: L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: July 6, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Johann Then, Klaus Bartsch, Hans-Matthias Deger, Susanne Grabley, Rudiger Marquardt
  • Process for preparing L-tertiary-Leucine and L-phosphinothricine by transamination
    Patent number: 5753470
    Abstract: L-tertiary-Leucine and L-phosphinothricine are obtainable by transamination of the corresponding keto acids as a precursor in the presence of amino acids as amino group donors. The reaction is preferably carried out with microorganisms or their transaminases.
    Type: Grant
    Filed: March 27, 1995
    Date of Patent: May 19, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Johann Then, Klaus Bartsch, Hans-Matthias Deger, Susanne Grabley, Rudiger Marquardt
  • Process for the preparation of L-phosphinothricin using transaminases of different specificities in a linked process
    Patent number: 5587319
    Abstract: L-2-Amino-4-methylphosphinobutyric acid can be prepared by a racemate resolution in the presence of D-aminoacid and L-aminoacid transaminases by reaction with .alpha.-keto acids and amino-group donors. In particular, transaminases from Bacillus licheniformis and from Escherichia coli are used.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: December 24, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Johann Then, Werner Aretz, Klaus Sauber
  • Cloning and use of the transaminase gene ilvE
    Patent number: 5120654
    Abstract: The ilvE gene from the strain E. coli ATCC 11303 is suitable for achieving overproduction of the coded aliphatic transaminase and thus for preparing the branched-chain amino acids leucine, isoleucine and valine from the corresponding keto precursors.
    Type: Grant
    Filed: August 13, 1990
    Date of Patent: June 9, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rudiger Marquardt, Johann Then, Hans-Matthias Deger, Gerhard Wohner, Martyn K. Robinson, Evelyn L. K. Doherty
  • Cloning and use of transaminase gene tyrB
    Patent number: 5091314
    Abstract: The isolation of the tyrB gene contained in E. coli ATCC 11303 and its cloning onto a multicopy plasmid results in a 10-fold increase in the L-phenylalanine yield after the transformation of the starting strain with this plasmid.
    Type: Grant
    Filed: August 13, 1990
    Date of Patent: February 25, 1992
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Rudiger Marquardt, Johann Then, Hans-Matthias Deger, Gerhard Wohner, Martyn K. Robinson, Andrew Doherty
  • Process for the preparation of L-phenylalanine
    Patent number: 4745059
    Abstract: L-Phenylalanine can be prepared using microorganisms belonging to the series comprising E. coli, Paracoccus denitrificans, Torula, Rhodotorula or Streptomyces after adaptation to phenylpyruvic acid, by amination with suitable sources of nitrogen. It is advantageous to employ the microorganism in the form of fixed cells.
    Type: Grant
    Filed: June 27, 1985
    Date of Patent: May 17, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hartmut Voelskow, Reinhold Keller, Merten Schlingmann, Martin Platen, Johann Then, Gerhard Wohner