Abstract: A method of quantifying lesion evolution, comprising: acquiring, by an MR scanning device, a first magnetic resonance, MR, sequence of a portion of a body comprising quantitative information of the portion; generating, by a processing circuit, a first MR image representing the portion, based on the first MR sequence, wherein each voxel of the first MR image represents a corresponding volume of the portion; and for a voxel of a first region of interest of the first MR image, determining a lesion evolution value indicating a status of lesion evolution, based on quantitative values of the voxel and a lesion evolution model; wherein the lesion evolution model comprises at least two sets of quantitative values comprising a first set of quantitative values representing the portion of an initial status of lesion evolution, and a second set of quantitative values representing the portion of a final status of lesion evolution.