Patents by Inventor Johanna C. Vanderspek

Johanna C. Vanderspek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Diphtheria toxin variant
    Patent number: 8865866
    Abstract: The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome. One aspect of the present invention relates to a polypeptide toxophore from a modified DT, wherein the mutation is the substitution or deletion at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of native DT. Another aspect of the present invention relates to a fusion protein which comprises a modified DT and a non-DT fragment. Another aspect of the present invention relates to the use of modified DT for the treatment of cancer.
    Type: Grant
    Filed: October 20, 2011
    Date of Patent: October 21, 2014
    Assignee: Anjin Group, Inc.
    Inventors: Robert J. Harrison, Johanna C. Vanderspek
  • Diphtheria Toxin Variant
    Publication number: 20120149650
    Abstract: The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome. One aspect of the present invention relates to a polypeptide toxophore from a modified DT, wherein the mutation is the substitution or deletion at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of native DT. Another aspect of the present invention relates to a fusion protein which comprises a modified DT and a non-DT fragment. Another aspect of the present invention relates to the use of modified DT for the treatment of cancer.
    Type: Application
    Filed: October 20, 2011
    Publication date: June 14, 2012
    Inventors: Robert J. Harrison, Johanna C. Vanderspek
  • Diphtheria toxin variant
    Patent number: 8048985
    Abstract: The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome. One aspect of the present invention relates to a polypeptide toxophore from a modified DT, wherein the mutation is the substitution or deletion at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of native DT. Another aspect of the present invention relates to a fusion protein which comprises a modified DT and a non-DT fragment. Another aspect of the present invention relates to the use of modified DT for the treatment of cancer.
    Type: Grant
    Filed: February 9, 2009
    Date of Patent: November 1, 2011
    Assignee: Anjin Group, Inc.
    Inventors: Robert J. Harrison, Johanna C. Vanderspek
  • Diphtheria toxin variant
    Patent number: 7585942
    Abstract: The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome. One aspect of the present invention relates to a polypeptide toxophore from a modified DT, wherein the mutation is the substitution or deletion at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of native DT. Another aspect of the present invention relates to a fusion protein which comprises a modified DT and a non-DT fragment. Another aspect of the present invention relates to the use of modified DT for the treatment of cancer.
    Type: Grant
    Filed: November 24, 2004
    Date of Patent: September 8, 2009
    Assignee: Anjin Corporation
    Inventors: Robert J. Harrison, Johanna C. Vanderspek
  • DIPHTHERIA TOXIN VARIANT
    Publication number: 20090156502
    Abstract: The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome. One aspect of the present invention relates to a polypeptide toxophore from a modified DT, wherein the mutation is the substitution or deletion at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of native DT. Another aspect of the present invention relates to a fusion protein which comprises a modified DT and a non-DT fragment. Another aspect of the present invention relates to the use of modified DT for the treatment of cancer.
    Type: Application
    Filed: February 9, 2009
    Publication date: June 18, 2009
    Inventors: ROBERT J. HARRISON, JOHANNA C. VANDERSPEK