Patents by Inventor Johanna Vanderspek

Johanna Vanderspek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20060167238
    Abstract: Disclosed are nucleic acid circuits and methods of using same to make proteins.
    Type: Application
    Filed: May 22, 2003
    Publication date: July 27, 2006
    Applicants: ADVANCED MICROBIAL SOLUTIONS CORPORATION, BOSTON MEDICAL CENTER CORPORATION
    Inventors: John Murphy, Robert Harrison, Johanna Vanderspek, John Love, Lori Bergeron
  • Publication number: 20060159708
    Abstract: The present invention relates to methods and compositions of modified variants of diphtheria toxin (DT) that reduce binding to vascular endothelium or vascular endothelial cells, and therefore, reduce the incidence of Vascular Leak Syndrome. One aspect of the present invention relates to a polypeptide toxophore from a modified DT, wherein the mutation is the substitution or deletion at least one amino acid residue at the amino acid residues 6-8, 28-30 or 289-291 of native DT. Another aspect of the present invention relates to a fusion protein which comprises a modified DT and a non-DT fragment. Another aspect of the present invention relates to the use of modified DT for the treatment of cancer.
    Type: Application
    Filed: November 24, 2004
    Publication date: July 20, 2006
    Inventors: Robert Harrison, Johanna Vanderspek