Patents by Inventor Johanne Kaplan

Johanne Kaplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MEBENDAZOLE CANCER THERAPIES AND METHODS OF USE
    Publication number: 20190175560
    Abstract: The disclosure relates to a method of treating cancer by administering to the subject a therapeutically effective amount of a composition comprising mebendazole.
    Type: Application
    Filed: December 3, 2018
    Publication date: June 13, 2019
    Inventors: Jamie Dempsey BARBER, Katherine ARLINE, William M. SIDERS, Johanne KAPLAN
  • Methods for preventing and treating A-beta oligomer-associated and/or -induced diseases and conditions
    Publication number: 20190151401
    Abstract: The disclosure pertains to methods of treating or preventing a disease or condition associated with and/or induced by soluble A-beta oligomer such as Alzheimer's disease by administering to a subject in need thereof conformation specific and/or selective antibodies or binding fragments thereof and related products.
    Type: Application
    Filed: October 1, 2018
    Publication date: May 23, 2019
    Inventors: Neil R. Cashman, Steven S. Plotkin, Judith Maxwell Silverman, Ebrima Gibbs, Johanne Kaplan
  • PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT AND PREVENTION OF GRAFT VERSES HOST DISEASE
    Publication number: 20180169153
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.
    Type: Application
    Filed: July 31, 2017
    Publication date: June 21, 2018
    Inventors: David Berry, Noubar B. Afeyan, Johanne Kaplan, Neal Gordon, Shaila Rahman
  • PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT AND PREVENTION OF GRAFT VERSUS HOST DISEASE
    Publication number: 20180071344
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.
    Type: Application
    Filed: April 24, 2017
    Publication date: March 15, 2018
    Inventors: David Berry, Noubar B. Afeyan, Johanne Kaplan, Neal Gordon, Shaila Rahman
  • PROBIOTIC COMPOSITIONS CONTAINING CLOSTRIDIALES FOR INHIBITING INFLAMMATION
    Publication number: 20180015130
    Abstract: Pharmaceutical compositions containing microbial entities are described herein. The pharmaceutical compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the pharmaceutical compositions to treat or prevent disorders of the local or systemic microbiome in a subject are also provided.
    Type: Application
    Filed: February 21, 2017
    Publication date: January 18, 2018
    Inventors: David Berry, Johanne Kaplan, Shaila Rahman
  • Methods of Treating Autoimmune Diseases
    Publication number: 20170326203
    Abstract: Novel methods for treating patients with autoimmune diseases are disclosed. The methods of the invention include first depleting circulating lymphocytes in the mammal, e.g., by administering anti-thymocyte antibody, and then, during the course of repopulation, administering to the mammal a therapeutically effective amount of latent TGF-? and/or another agent that promotes expansion of regulatory T cells. In certain aspects, the disclosed process results in improved kidney function and survival rates.
    Type: Application
    Filed: August 2, 2017
    Publication date: November 16, 2017
    Applicant: GENZYME CORPORATION
    Inventors: Johanne Kaplan, John M. McPherson
  • Methods of treating autoimmune diseases
    Patent number: 9744233
    Abstract: Novel methods for treating patients with autoimmune diseases are disclosed. The methods of the invention include first depleting circulating lymphocytes in the mammal, e.g., by administering anti-thymocyte antibody, and then, during the course of repopulation, administering to the mammal a therapeutically effective amount of latent TGF-? and/or another agent that promotes expansion of regulatory T cells. In certain aspects, the disclosed process results in improved kidney function and survival rates.
    Type: Grant
    Filed: November 19, 2012
    Date of Patent: August 29, 2017
    Assignee: GENZYME CORPORATION
    Inventors: Johanne Kaplan, John McPherson
  • Methods of Treating Autoimmune Diseases
    Publication number: 20170165360
    Abstract: Novel methods for treating patients with autoimmune diseases are disclosed. The methods of the invention include first depleting circulating lymphocytes in the mammal, e.g., by administering anti-thymocyte antibody, and then, during the course of repopulation, administering to the mammal a therapeutically effective amount of latent TGF-? and/or another agent that promotes expansion of regulatory T cells. In certain aspects, the disclosed process results in improved kidney function and survival rates.
    Type: Application
    Filed: November 19, 2012
    Publication date: June 15, 2017
    Inventors: Johanne KAPLAN, John M. McPHERSON
  • Probiotic compositions containing clostridiales for inhibiting inflammation
    Patent number: 9610307
    Abstract: Pharmaceutical compositions containing microbial entities are described herein. The pharmaceutical compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the pharmaceutical compositions to treat or prevent disorders of the local or systemic microbiome in a subject are also provided.
    Type: Grant
    Filed: November 25, 2015
    Date of Patent: April 4, 2017
    Assignee: Evelop Biosciences, Inc.
    Inventors: David Berry, Johanne Kaplan, Shaila Rahman
  • Probiotic and prebiotic compositions, and methods of use thereof for treatment and prevention of graft versus host disease
    Patent number: 9603878
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.
    Type: Grant
    Filed: December 14, 2015
    Date of Patent: March 28, 2017
    Assignee: Evelo Biosciences, Inc.
    Inventors: David Berry, Shaila Rahman, Johanne Kaplan, Neal Gordon
  • PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT OF GASTROINTESTINAL DISORDERS
    Publication number: 20160271188
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent disorders of the local or systemic microbiome, e.g., gastrointestinal disorders, in a subject are also provided.
    Type: Application
    Filed: November 25, 2015
    Publication date: September 22, 2016
    Inventors: David Berry, Noubar B. Afeyan, Johanne Kaplan, Shaila Rahman
  • PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT AND PREVENTION OF GRAFT VERSUS HOST DISEASE
    Publication number: 20160235792
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.
    Type: Application
    Filed: November 25, 2015
    Publication date: August 18, 2016
    Inventors: David Berry, Noubar B. Afeyan, Johanne Kaplan, Neal Gordon, Shaila Rahman
  • PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR MODULATION OF THE MICROBIOME
    Publication number: 20160199424
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent disorders of the local or systemic microbiome in a subject are also provided.
    Type: Application
    Filed: November 25, 2015
    Publication date: July 14, 2016
    Inventors: David Berry, Noubar B. Afeyan, Johanne Kaplan, Shaila Rahman
  • PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT AND PREVENTION OF GRAFT VERSUS HOST DISEASE
    Publication number: 20160193258
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.
    Type: Application
    Filed: November 25, 2015
    Publication date: July 7, 2016
    Inventors: David Berry, Noubar B. Afeyan, Johanne Kaplan, Neal Gordon, Shaila Rahman
  • PROBIOTIC AND PREBIOTIC COMPOSITIONS, AND METHODS OF USE THEREOF FOR TREATMENT AND PREVENTION OF GRAFT VERSUS HOST DISEASE
    Publication number: 20160143961
    Abstract: Probiotic compositions containing non-pathogenic microbial entities, e.g., bacterial or fungal entities, are described herein. The probiotic compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the probiotic compositions to treat or prevent transplant disorders, e.g., graft-versus-host disease (GVHD), in a subject are also provided.
    Type: Application
    Filed: December 14, 2015
    Publication date: May 26, 2016
    Inventors: David Berry, Shaila Rahman, Noubar B. Afeyan, Johanne Kaplan, Neal Gordon
  • PROBIOTIC COMPOSITIONS CONTAINING CLOSTRIDIALES FOR INHIBITING INFLAMMATION
    Publication number: 20160143962
    Abstract: Pharmaceutical compositions containing microbial entities are described herein. The pharmaceutical compositions may optionally contain or be used in conjunction with one or more prebiotics. Uses of the pharmaceutical compositions to treat or prevent disorders of the local or systemic microbiome in a subject are also provided.
    Type: Application
    Filed: November 25, 2015
    Publication date: May 26, 2016
    Inventors: David Berry, Johanne Kaplan
  • Methods of Treating Autoimmune Diseases
    Publication number: 20150044164
    Abstract: Novel methods for treating patients with autoimmune diseases are disclosed. The methods of the invention include first depleting circulating lymphocytes in the mammal, e.g., by administering anti-thymocyte antibody, and then, during the course of repopulation, administering to the mammal a therapeutically effective amount of latent TGF-? and/or another agent that promotes expansion of regulatory T cells. In certain aspects, the disclosed process results in improved kidney function and survival rates.
    Type: Application
    Filed: November 19, 2012
    Publication date: February 12, 2015
    Applicant: GENZYME CORPORATION
    Inventors: Johanne KAPLAN, John M. McPHERSON
  • Methods of Using Anti-Thymocyte Globulin and Related Agents
    Publication number: 20130344092
    Abstract: Novel uses for anti-thymocyte globulin (ATG, e.g., Thymoglobulin®) and related compositions are described. In one aspect, ATG and, optionally, TGF-? are used for in vitro generation of regulatory T cells, which are useful for cell therapy of immune-mediated conditions. In another aspect, ATG is directly administered to a subject at a low dose (e.g., less than 1 mg/kg per day) to treat an immune-mediated condition. The immune-mediated conditions include, for example, transplant rejection, graft-versus-host disease, and autoimmune diseases.
    Type: Application
    Filed: August 28, 2013
    Publication date: December 26, 2013
    Applicants: The Brigham and Women's Hospital, Inc., Genzyme Corporation
    Inventors: Nader Najafian, Mohamed H. Sayegh, Melanie Ruzek, Srinivas Shankara, John Williams, Johanne Kaplan, John M. McPherson
  • METHODS AND COMPOSITIONS FOR TREATING HEMATOLOGICAL MALIGNANCIES
    Publication number: 20110280827
    Abstract: The invention relates to methods and compositions for treating a subject afflicted with a hematological malignancy using a combination of a CXCR4 antagonist and an immunotherapeutic agent.
    Type: Application
    Filed: January 28, 2010
    Publication date: November 17, 2011
    Inventors: Yanping Hu, William Siders, Johanne Kaplan
  • Methods of Using Anti-Thymocyte Globulin and Related Agents
    Publication number: 20100034782
    Abstract: Uses for anti-thymocyte globulin (ATG, e.g., Thymoglobulin®) and related compositions are described. In one aspect, ATG and, optionally, TGF-beta are used for in vitro generation of regulatory T cells, which are useful for cell therapy of immune-mediated conditions. In another aspect, ATG is directly administered to a subject at a low dose (e.g., less than 1 mg/kg per day) to treat an immune-mediated condition. The immune-mediated conditions include, for example, transplant rejection, graft-versus-host disease, and autoimmune diseases.
    Type: Application
    Filed: May 31, 2007
    Publication date: February 11, 2010
    Inventors: Nader Najafian, Mohamed H. Sayegh, Melanie Ruzek, Srinivas Shankara, John Williams, Johanne Kaplan, John M. McPherson