Patents by Inventor Johanne M. Kaplan

Johanne M. Kaplan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR TREATING LUPUS
    Publication number: 20170369583
    Abstract: The invention provides methods of treating lupus in a patient with an anti-CD52 antibody. Also includes are methods of increasing infiltration of regulatory T cells to affected sides of the patient's body, methods of reducing urine protein and/or albumin levels and methods of depleting lymphocytes to alleviate lupus symptoms.
    Type: Application
    Filed: March 1, 2017
    Publication date: December 28, 2017
    Applicant: GENZYME CORPORATION
    Inventors: Johanne M. Kaplan, Bruce L. Roberts, William M. Siders
  • Methods and compositions for treating lupus
    Patent number: 9617343
    Abstract: The invention provides methods of treating lupus in a patient with an anti-CD52 antibody. Also includes are methods of increasing infiltration of regulatory T cells to affected sides of the patient's body, methods of reducing urine protein and/or albumin levels and methods of depleting lymphocytes to alleviate lupus symptoms.
    Type: Grant
    Filed: May 13, 2010
    Date of Patent: April 11, 2017
    Assignee: GENZYME CORPORATION
    Inventors: Johanne M. Kaplan, Bruce L. Roberts, William M. Siders
  • METHODS AND COMPOSITIONS FOR TREATING LUPUS
    Publication number: 20120070408
    Abstract: The invention provides methods of treating lupus in a patient with an anti-CD52 antibody. Also includes are methods of increasing infiltration of regulatory T cells to affected sides of the patient's body, methods of reducing urine protein and/or albumin levels and methods of depleting lymphocytes to alleviate lupus symptoms.
    Type: Application
    Filed: May 13, 2010
    Publication date: March 22, 2012
    Applicant: GENZYME CORPORATION
    Inventors: Johanne M. Kaplan, Bruce L. Roberts, William M. Siders
  • METHODS AND COMPOSITIONS FOR TREATMENT
    Publication number: 20120058082
    Abstract: The invention provides methods for improving the efficacy and reducing side effects of anti-CD52 antibody treatment. The methods can be used to treat patients who are in need of immunoregulation such as lymphocyte depletion and patients who have cancer. Also included are compositions useful for these methods.
    Type: Application
    Filed: May 13, 2010
    Publication date: March 8, 2012
    Applicant: GENZYME CORPORATION
    Inventors: Johanne M. Kaplan, Bruce L. Roberts, William M. Siders
  • Methods of Treating Autoimmune Diseases
    Publication number: 20100183541
    Abstract: Novel methods for treating patients with autoimmune diseases are disclosed. The methods of the invention include first depleting circulating lymphocytes in the mammal, e.g., by administering anti-thymocyte antibody, and then, during the course of repopulation, administering to the mammal a therapeutically effective amount of latent TGF-? and/or another agent that promotes expansion of regulatory T cells. In certain aspects, the disclosed process results in improved kidney function and survival rates.
    Type: Application
    Filed: September 30, 2008
    Publication date: July 22, 2010
    Inventors: Johanne M. Kaplan, John M. McPherson