Patents by Inventor Johannes A. Meienhofer

Johannes A. Meienhofer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic vasoactive intestinal peptide analogs
    Patent number: 4734400
    Abstract: Novel vasoactive intestinal peptide analogs containing substitutions of appropriately selected amino acids at specific positions of the VIP molecule, with potent sustained bronchodilatory activity without cardiovascular side effects.
    Type: Grant
    Filed: June 16, 1986
    Date of Patent: March 29, 1988
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David R. Bolin, Johannes A. Meienhofer, Iou-Iou Sytwu
  • Synthetic vasoactive intestinal peptide analogs
    Patent number: 4605641
    Abstract: Novel vasoactive intestinal peptide analogs containing substitutions of appropriately selected amino acids at specific positions of the VIP molecule, with potent sustained bronchodilatory activity without cardiovascular side effects.
    Type: Grant
    Filed: October 9, 1984
    Date of Patent: August 12, 1986
    Assignee: Hoffmann-La Roche Inc.
    Inventors: David R. Bolin, Johannes A. Meienhofer, Iou-Iou Sytwu
  • Synthesis of thymosin .alpha..sub.1
    Patent number: 4517119
    Abstract: An improved solution phase synthesis of thymosin .alpha..sub.1 and proceeding through novel intermediates is disclosed.
    Type: Grant
    Filed: April 4, 1983
    Date of Patent: May 14, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur M. Felix, Dieter Gillessen, William Lergier, Johannes A. Meienhofer, Arnold Trzeciak
  • Synthesis of thymosin .alpha..sub.1 and desacetyl thymosin .alpha..sub.1
    Patent number: 4504415
    Abstract: An improved solution phase synthesis of thymosin .alpha..sub.1 and desacetyl thymosin .alpha..sub.1 with t-Boc side chain protection and proceeding through novel intermediates is disclosed.
    Type: Grant
    Filed: April 4, 1983
    Date of Patent: March 12, 1985
    Assignee: Hoffman-La Roche Inc.
    Inventors: Arthur M. Felix, Dieter Gillessen, Rolf Studer, Johannes A. Meienhofer, Arnold Trzeciak
  • Immunopotentiating peptides
    Patent number: 4442031
    Abstract: Novel hexapeptides corresponding to internal fragments of thymosin .alpha..sub.1 are active as agents which restore and stimulate immune function.
    Type: Grant
    Filed: April 5, 1983
    Date of Patent: April 10, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Arthur M. Felix, Hideo Ishitsuka, Johannes A. Meienhofer, Yumiko Ohta
  • Immunopotentiating peptides
    Patent number: 4426324
    Abstract: Novel di-to heptapeptides representing fragments of the carboxyl terminal of thymosin .alpha..sub.1 are active as agents which affect regulation, differentiation and function of thymus dependent lymphocytes.
    Type: Grant
    Filed: April 28, 1980
    Date of Patent: January 17, 1984
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Johannes A. Meienhofer
  • Synthesis and biological activity of [D-Thr.sup.2, .DELTA..sup.3 Pro.sup.5 ]-enkephalinamide
    Patent number: 4238390
    Abstract: The present disclosure is directed to the synthesis and biological activity of [D-Thr.sup.2, .DELTA..sup.3 Pro.sup.5 ]-enkephalinamide. The subject compound is useful as an agent for the inhibition of diarrhea and also exhibits analgesic activity.
    Type: Grant
    Filed: May 9, 1979
    Date of Patent: December 9, 1980
    Assignee: Hoffmann-La Roche Inc.
    Inventor: Johannes A. Meienhofer
  • Aminoethylglycine containing polypeptides
    Patent number: 4145337
    Abstract: Novel somatostatin analogues containing one or more aminoethylglycyl residues at the amino and/or carboxyl terminus or in the ring position are described. The compounds are potent and long lasting inhibitors of gastric acid secretion.
    Type: Grant
    Filed: October 11, 1977
    Date of Patent: March 20, 1979
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Wallace M. Dairman, Arthur M. Felix, Hugo E. Gallo-Torres, Edgar P. Heimer, Johannes A. Meienhofer
  • Synthesis of human .beta.-endorphin
    Patent number: 4105652
    Abstract: Human .beta.-endorphin (.beta..sub.h -endorphin) is prepared by solution phase peptide synthesis. Synthesis proceeded via the protected .beta.-endorphin fragments 1-9, 10-18, 19-21 and 22-31.
    Type: Grant
    Filed: August 5, 1977
    Date of Patent: August 8, 1978
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Johannes A. Meienhofer, Su-Sun Wang