Patents by Inventor Johannes Anna Wilhelmus Kruijtzer

Johannes Anna Wilhelmus Kruijtzer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tunable, biodegradable linker molecules for transient conjugation of components in drug delivery systems, and drug delivery systems prepared therewith
    Patent number: 9339554
    Abstract: The present invention relates to a particular class of biodegradable linkers, ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems (DDS), such as DDS based on polymeric micelles or hydrogels. In addition, the present invention relates to compounds, comprising said linkers, such compounds preferably being prodrugs. Further, the invention is directed to the use of said linkers, and especially said biodegradable linkers, in a drug delivery system. Moreover, the invention relates to controlled release system comprising a polymer matrix, capable of releasing an active ingredient, wherein the active ingredient is covalently linked to the polymer molecules of the polymer matrix through said linkers, as well as to a method of synthesizing these linkers and preparing such controlled release systems.
    Type: Grant
    Filed: July 14, 2011
    Date of Patent: May 17, 2016
    Assignee: CRISTAL DELIVERY B.V.
    Inventors: Cristianne Johanna Ferdinand Rijcken, Wilhelmus Everhardus Hennink, Cornelis Franciscus van Nostrum, Isil Altintas, Steffen van der Wal, Robertus Matthias Joseph Liskamp, Johannes Anna Wilhelmus Kruijtzer
  • TUNABLE, BIODEGRADABLE LINKER MOLECULES FOR TRANSIENT CONJUGATION OF COMPONENTS IN DRUG DELIVERY SYSTEMS, AND DRUG DELIVERY SYSTEMS PREPARED THEREWITH
    Publication number: 20130261094
    Abstract: The present invention relates to a particular class of biodegradable linkers, ensuring transiently stable conjugation of building blocks and/or bioactive compounds into drug delivery systems (DDS), such as DDS based on polymeric micelles or hydrogels. In addition, the present invention relates to compounds, comprising said linkers, such compounds preferably being prodrugs. Further, the invention is directed to the use of said linkers, and especially said biodegradable linkers, in a drug delivery system. Moreover, the invention relates to controlled release system comprising a polymer matrix, capable of releasing an active ingredient, wherein the active ingredient is covalently linked to the polymer molecules of the polymer matrix through said linkers, as well as to a method of synthesising these linkers and preparing such controlled release systems.
    Type: Application
    Filed: July 14, 2011
    Publication date: October 3, 2013
    Applicant: Cristal Delivery B.V.
    Inventors: Cristianne Johanna Ferdinand Rijcken, Wilhelmus Everhardus Hennink, Cornelis Franciscus van Nostrum, Isil Altintas, Steffen van der Wal, Robertus Matthias Joseph Liskamp, Johannes Anna Wilhelmus Kruijtzer