Patents by Inventor Johannes Bartholomaeus

Johannes Bartholomaeus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20140105830
    Abstract: The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N and to a process for the production thereof.
    Type: Application
    Filed: December 23, 2013
    Publication date: April 17, 2014
    Applicant: GRUENENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU MARIC
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20140093559
    Abstract: A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
    Type: Application
    Filed: November 1, 2013
    Publication date: April 3, 2014
    Applicant: GRUNENTHAL GMBH
    Inventors: JOHANNES BARTHOLOMAEUS, HEINRICH KUGELMANN
  • DOSAGE FORM THAT IS SAFEGUARDED FROM ABUSE
    Publication number: 20140086847
    Abstract: The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
    Type: Application
    Filed: November 27, 2013
    Publication date: March 27, 2014
    Applicant: GRUNENTHAL GMBH
    Inventors: Elisabeth ARKENAU MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • Crush resistant delayed-release dosage forms
    Publication number: 20140079780
    Abstract: The invention relates to a dosage form comprising a physiologically effective amount of a physiologically active substance (A), a synthetic, semi-synthetic or natural polymer (C), optionally one or more physiologically acceptable auxiliary substances (B) and optionally a synthetic, semi-synthetic or natural wax (D), wherein the dosage form exhibits a resistance to crushing of at least 400 N and wherein under physiological conditions the release of the physiologically active substance (A) from the dosage form is at least partially delayed.
    Type: Application
    Filed: November 19, 2013
    Publication date: March 20, 2014
    Applicant: GRUENENTHAL GMBH
    Inventors: Elisabeth ARKENAU MARIC, Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • Abuse-proofed dosage forms
    Publication number: 20140080858
    Abstract: The invention relates to a form of administration which is secured against misuse and which is thermoformed without extrusion, comprising at least one synthetic or natural polymer having a resistance to breaking of at least 500 N in addition to one or several active ingredients with a misuse potential and, optionally physiologically compatible auxiliary substances. The invention also relates to a method for the production thereof.
    Type: Application
    Filed: November 20, 2013
    Publication date: March 20, 2014
    Applicant: GRUENENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU MARIC
  • Abuse-proofed dosage forms
    Publication number: 20140080915
    Abstract: The invention relates to a form of administration which is secured against misuse and which is thermoformed without extrusion, comprising at least one synthetic or natural polymer having a resistance to breaking of at least 500 N in addition to one or several active ingredients with a misuse potential and, optionally physiologically compatible auxiliary substances. The invention also relates to a method for the production thereof.
    Type: Application
    Filed: November 22, 2013
    Publication date: March 20, 2014
    Applicant: GRUENENTHAL GMBH
    Inventors: Johannes Bartholomäus, Heinrich Kugelmann, Elisabeth Arkenau Maric
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20130287846
    Abstract: The present invention relates to an abuse-proofed oral dosage form with controlled release of (1R,2R)-3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol for once daily administration, which comprises the active ingredient and/or one or more of the pharmaceutically acceptable salts thereof (A), at least one synthetic or natural polymer (C), delayed-release auxiliary substances, optionally physiologically acceptable auxiliary substances (B) and optionally a wax (D), component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: June 26, 2013
    Publication date: October 31, 2013
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN
  • ABUSE-PROOFED ORAL DOSAGE FORM
    Publication number: 20130251643
    Abstract: The present invention relates to an abuse-proofed, oral dosage form with controlled opioid-release for once daily administration, characterised in that it comprises at least one opioid with potential for abuse (A), at least one synthetic or natural polymer (C), optionally delayed-release matrix auxiliary substances, physiologically acceptable auxiliary substances (B), optionally a wax (D) and optionally at least one delayed-release coating, component (C) or (D) in each case exhibiting a breaking strength of at least 500 N, preferably of at least 1000 N.
    Type: Application
    Filed: May 20, 2013
    Publication date: September 26, 2013
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • Prolonged Release Pharmaceutical Composition Containing 3-(3-Dimethylamino-1-Ethyl-2-Methyl-Propyl)Phenol
    Publication number: 20130237608
    Abstract: A pharmaceutical formulation for prolonged release of the active ingredient 3-(3-dimethylamino-1-ethyl-2-methylpropyl)phenol or a pharmaceutically acceptable salt thereof in a matrix containing between 1 and 80 wt. % of at least one pharmaceutically acceptable hydrophilic or hydrophobic polymer as a matrix forming agent and exhibiting in vivo the following release rate: 3 to 35% by weight (based on 100% by weight active ingredient) 3-(3-dimethylamino-1-ethyl-2-methyl-propyl)phenol released after 0.
    Type: Application
    Filed: April 23, 2013
    Publication date: September 12, 2013
    Applicant: GRUENENTHAL GmbH
    Inventors: Johannes BARTHOLOMAEUS, Iris ZIEGLER
  • PHOSPHATE BINDER FORMULATION FOR SIMPLE DOSING
    Publication number: 20130202699
    Abstract: The invention relates to a pharmaceutical composition in the form of pourable granules or a chewable tablet containing at least one phosphate binding substance and at least one effervescent agent. The composition may be taken orally without adding water.
    Type: Application
    Filed: October 11, 2011
    Publication date: August 8, 2013
    Applicant: FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
    Inventors: Kai Strothmann, Friedrich Schulze, Johannes Bartholomaeus, Eva Fries-Schaffner, Astrid Oppermann
  • Abuse-proofed dosage form
    Patent number: 8420056
    Abstract: The invention relates to a dosage form that is thermoshaped without being extruded and that is safeguarded from abuse, comprising at least one synthetic or natural polymer having a breaking strength of at least 500 N in addition to one or more active substances that could be subject to abuse and optionally physiologically acceptable adjuvants. The invention also relates to a corresponding method for producing said dosage form.
    Type: Grant
    Filed: October 11, 2011
    Date of Patent: April 16, 2013
    Assignee: Grunenthal GmbH
    Inventors: Elisabeth Arkenau-Maric, Johannes Bartholomäus, Heinrich Kugelmann
  • Pharmaceutical dosage form
    Patent number: 8383152
    Abstract: The invention relates to a pharmaceutical dosage form, preferably with controlled release of a pharmacologically active compound (A) contained therein, the pharmaceutical dosage form very preferably being tamper-resistant and most preferably having a breaking strength B1 of at least 500 N in direction of extension E1 and having a breaking strength B2 of less than 500 N in direction of extension E2.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: February 26, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Eugeen Marie Jozef Jans, Filip René Irena Kiekens, Jody Firmin Marceline Voorspoels, Anne Faure, Elisabeth Arkenau-Maric, Lutz Barnscheid, Johannes Bartholomäus, Marc Frevel, Eric Galia, Iris Ziegler, Andrea Schüssele
  • Fast release dosage forms for antibiotics
    Patent number: 8361506
    Abstract: A multiparticulate, pharmaceutical dosage form containing at least one antibiotic which is sparingly wettable with aqueous media or sparingly soluble in aqueous media and a combination of carrageenan and tricalcium phosphate and optionally sucrose ester. Also, an administration system having this dosage form arranged in a drinking straw with at least one barrier device for single administration, optionally together with a conveying liquid.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: January 29, 2013
    Assignee: Gruenenthal GmbH
    Inventors: Iris Ziegler, Johannes Bartholomäus, Jessica Redmer
  • ABUSE-PROOFED DOSAGE FORM
    Publication number: 20120308654
    Abstract: A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
    Type: Application
    Filed: August 13, 2012
    Publication date: December 6, 2012
    Applicant: GRUNENTHAL GMBH
    Inventors: JOHANNES BARTHOLOMÄUS, HEINRICH KUGELMANN
  • Process for the production of an abuse-proofed solid dosage form
    Patent number: 8323889
    Abstract: The present invention relates to a process for the production of an abuse-proofed solid dosage form containing at least one active ingredient with potential for abuse and a synthetic or natural polymer with a breaking strength of =500 N, characterized in that a corresponding mixture is processed by melt extrusion with the assistance of a planetary-gear extruder.
    Type: Grant
    Filed: June 17, 2008
    Date of Patent: December 4, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Elisabeth Arkenau-Maric, Johannes Bartholomäus, Heinrich Kugelmann
  • TUBING SET HAVING A GATE FOR THE CONNECTION OF VIALS
    Publication number: 20120271274
    Abstract: The present invention refers to a tubing set (12) suitable for use in co-operation with a hemodialysis machine (10). The tubing set comprises: an out-tube (14) for supplying the blood from the patient to a filter (16) of the machine; an in-tube (18) for supplying the blood from the filter back to the patient; a drip chamber (20) placed along one of said tubes, adapted to let the blood drip through an air buffer (22); and a vial gate (24) for the connection of vials (26) containing drugs to be delivered into the blood. The vial gate (24) according to the invention comprises a delivery lumen (28), suitable for delivering the drug (30) from the vial to the drip chamber, and a vent lumen (32), suitable for providing air (34) inside the vial in order to replace the delivered drug.
    Type: Application
    Filed: October 25, 2010
    Publication date: October 25, 2012
    Inventors: Reinhold Reiter, Massimo Fini, Alain Veneroni, Johannes Bartholomaeus, Gerhard Wiesen
  • Abuse-proofed dosage form
    Publication number: 20120251637
    Abstract: The present invention relates to an abuse-proofed, thermoformed dosage form containing, in addition to one or more active ingredients with abuse potential optionally together with physiologically acceptable auxiliary substances, at least one synthetic or natural polymer with a breaking strength of at least 500 N and to a process for the production thereof.
    Type: Application
    Filed: June 14, 2012
    Publication date: October 4, 2012
    Applicant: GRUENENTHAL GMBH
    Inventors: Johannes BARTHOLOMÄUS, Heinrich KUGELMANN, Elisabeth ARKENAU-MARIC
  • Abuse-proofed dosage form
    Publication number: 20120135071
    Abstract: A solid administration form, protected from parenteral abuse and containing at least one viscosity-increasing agent in addition to one or more active substances that have parenteral abuse potential. The agent forms, when a necessary minimum amount of an aqueous liquid is added, on the basis of an extract obtained from the administration form, a preferably injectable gel that remains visually distinct when introduced into another quantity of an aqueous liquid.
    Type: Application
    Filed: February 3, 2012
    Publication date: May 31, 2012
    Applicant: Grunenthal GmbH
    Inventors: Johannes Bartholomäus, Heinrich Kugelmann
  • OXIDATION-STABILIZED TAMPER-RESISTANT DOSAGE FORM
    Publication number: 20120136021
    Abstract: A thermoformed pharmaceutical dosage form having a breaking strength of at least 300 N, said dosage form comprising a pharmacologically active ingredient (A), a free physiologically acceptable acid (B) in an amount of from 0.001 wt.-% to 5.0 wt.-%, based on the total weight of the pharmaceutical dosage form, and a polyalkylene oxide (C) having a weight average molecular weight Mw of at least 200,000 g/mol.
    Type: Application
    Filed: January 5, 2012
    Publication date: May 31, 2012
    Applicant: GRUNENTHAL GMBH
    Inventors: Lutz Barnscheid, Eric Galia, Sebastian Schwier, Ulrike Bertram, Anja Geissler, Kornelia Griessmann, Johannes Bartholomäus
  • Oral administration forms for administering a fixed tramadol and diclofenac combination
    Patent number: 8173164
    Abstract: An oral administration unit containing the active substances Tramadol and Diclofenac and/or physiologically acceptable salts thereof, in which both active substances are contained in the same administration unit as two separately formulated subunits.
    Type: Grant
    Filed: September 22, 2003
    Date of Patent: May 8, 2012
    Assignee: Gruenenthal GmbH
    Inventors: Johannes Bartholomaeus, Iris Ziegler