Patents by Inventor Johannes Czernin

Johannes Czernin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION CANCER THERAPY
    Publication number: 20190000850
    Abstract: Described herein, inter alia, are anti-cancer agents, anti-cancer pharmaceutical compositions, combinations of the agents and/or pharmaceutical compositions, and methods of using the same.
    Type: Application
    Filed: February 9, 2016
    Publication date: January 3, 2019
    Inventors: Caius Gabriel Radu, Soumya Poddar, Johannes Czernin, David Nathanson, Thuc Le
  • Supramolecular approach for preparation of size controllable nanoparticles
    Patent number: 9845237
    Abstract: A supramolecular approach has been developed for preparation of size-controllable nanoparticles, from three different molecular building blocks.
    Type: Grant
    Filed: February 26, 2010
    Date of Patent: December 19, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Hsian-Rong Tseng, Hao Wang, Shutao Wang, Helen Su, Caius G. Radu, Johannes Czernin
  • Deoxycytidine kinase binding compounds
    Patent number: 9688673
    Abstract: The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.
    Type: Grant
    Filed: March 8, 2012
    Date of Patent: June 27, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Caius G. Radu, Hsiang-I Liao, Nagichettiar Satyamurthy, Johannes Czernin, Jennifer M. Murphy, David A. Nathanson
  • NON-IMMUNOGENIC POSITRON EMISSION TOMOGRAPHY REPORTER GENE SYSTEMS
    Publication number: 20140248212
    Abstract: Embodiments of the invention include a PET/SPECT reporter gene system that uses enhanced non-immunogenic versions of a human mitochondrial thymidine kinase 2 expressed in cytoplasm to preferentially trap novel PET/SPECT radiolabeled L and D-enantiomer analogs of the natural substrate thymidine. Such highly sensitive, non-immunogenic reporter genes function in combination with a set of novel, radiolabeled probes in whole body molecular imaging applications using positron emission tomography (PET) or single photon emission computed tomography (SPECT).
    Type: Application
    Filed: August 6, 2012
    Publication date: September 4, 2014
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Caius G. Radu, Johannes Czernin, Dean O. Campbell, Shahriar S. Yaghoubi, Nagichettiar Satyamurthy, Arnon Lavie
  • DEOXYCYTIDINE KINASE BINDING COMPOUNDS
    Publication number: 20130336883
    Abstract: The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.
    Type: Application
    Filed: March 8, 2012
    Publication date: December 19, 2013
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Caius G. Radu, Hsiang-I Liao, Nagichettiar Satyamurthy, Johannes Czernin, Jennifer M. Murphy, David A. Nathanson
  • Positron emission tomography probes for imaging immune activation and selected cancers
    Patent number: 8101740
    Abstract: Compounds for use as PET probes and methods for synthesizing and using these, comprising [18F]D-FAC and other cytosine and adenosine analogs.
    Type: Grant
    Filed: September 19, 2008
    Date of Patent: January 24, 2012
    Assignee: The Regents of the University of California
    Inventors: Caius G. Radu, Owen N. Witte, Evan David Nair-Gill, Nagichettiar Satyamurthy, Chengyi J. Shu, Johannes Czernin
  • SUPRAMOLECULAR APPROACH FOR PREPARATION OF SIZE CONTROLLABLE NANOPARTICLES
    Publication number: 20110305685
    Abstract: A supramolecular approach has been developed for preparation of size-controllable nanoparticles, from three different molecular building blocks.
    Type: Application
    Filed: February 26, 2010
    Publication date: December 15, 2011
    Applicant: The Regents of the University of California
    Inventors: Hsian-Rong Tseng, Hao Wang, Shutao Wang, Helen Su, Caius G. Radu, Johannes Czernin
  • POSITRON EMISSION TOMOGRAPHY PROBES FOR IMAGING IMMUNE ACTIVATION AND SELECTED CANCERS
    Publication number: 20090105184
    Abstract: Compounds for use as PET probes and methods for synthesizing and using these, comprising [18F]D-FAC and other cytosine and adenosine analogs.
    Type: Application
    Filed: September 19, 2008
    Publication date: April 23, 2009
    Applicant: The Regents of the University of California
    Inventors: Caius G. Radu, Owen N. Witte, Evan David Nair-Gill, Nagichettiar Satyamurthy, Chengyi J. Shu, Johannes Czernin
  • Apparatus and method for breast cancer imaging
    Patent number: 6552348
    Abstract: A detector for use in a dedicated PET scanner for cancer applications, particularly breast cancer applications, using a LSO scintillator, a lightguide coupling arrangement, and an efficient way to construct the scintillator array, which provides a flexible imaging system for breast cancer applications with high sensitivity and high spatial resolution in a compact, cost effective, design.
    Type: Grant
    Filed: December 14, 2000
    Date of Patent: April 22, 2003
    Assignee: Regents of the University of California
    Inventors: Simon R. Cherry, Johannes Czernin, Niraj K. Doshi, Yiping Shao, Robert W. Silverman
  • Apparatus and method for breast cancer imaging
    Publication number: 20010040219
    Abstract: A detector for use in a dedicated PET scanner for cancer applications, particularly breast cancer applications, using a LSO scintillator, a lightguide coupling arrangement, and an efficient way to construct the scintillator array, which provides a flexible imaging system for breast cancer applications with high sensitivity and high spatial resolution in a compact, cost effective, design.
    Type: Application
    Filed: December 14, 2000
    Publication date: November 15, 2001
    Inventors: Simon R. Cherry, Johannes Czernin, Niraj K. Doshi, Yiping Shao, Robert W. Silverman