Patents by Inventor Johannes Dodt

Johannes Dodt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Thrombin inhibitors
    Patent number: 5583111
    Abstract: The invention relates to novel polypeptides with antithrombin activity obtainable from extracts of tissues or secretions of leeches of the order Rhynchobdellida, particularly of the species Theromyzon tessulatum. The polypetides have molecular weights of about 14 kD, 9 kD and 3 kD and can be used in pharmaceutical compositions for the treatment of thrombosis related disorders and events.
    Type: Grant
    Filed: January 5, 1995
    Date of Patent: December 10, 1996
    Assignee: Merck Patent Gesellschaft Mit Beshrankter Haftung
    Inventors: J urgen Hemberger, Roy Sawyer, Sabine Wolf, Johannes Dodt
  • Method of inhibiting blood clotting with desulfatohirudins
    Patent number: 4801576
    Abstract: The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof. The desulfatohirudins of this invention correspond to hirudin in biological activity and are therefore particularly useful for inhibiting blood clotting.
    Type: Grant
    Filed: January 19, 1988
    Date of Patent: January 31, 1989
    Assignee: Ciba-Geigy Corporation
    Inventors: Hans Fritz, Johannes Dodt, Ursula Seemuller, Ernst Fink
  • Hirudin-PA and its derivatives, process for manufacturing these and the use of these substances
    Patent number: 4767742
    Abstract: The present invention relates to a new content substance found in leeches (Hirudo medicinalis), the derivatives of this abbreviated at the N-terminus and the C-terminus, and the desulfated derivatives therefrom as well as a process for the production of these compounds, and their use. These compounds possess thrombin-inhibiting properties and can be used to inhibit clotting in human and animals, for blood conservation, or as reagents for the analytical determination of thrombin.
    Type: Grant
    Filed: August 6, 1986
    Date of Patent: August 30, 1988
    Assignee: Plantorgan-Werk Heinrich G. F. Christensen, KG
    Inventors: Johannes Dodt, Ursula Seemuller, Hans Fritz, Ernst Fink
  • Desulfatohirudins, the preparation thereof and pharmaceutical compositions containing them
    Patent number: 4745177
    Abstract: The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof.The desulfatohirudins of this invention correspond to hirudin in biological activity and are therefore particularly useful for inhibiting blood clotting.
    Type: Grant
    Filed: November 13, 1986
    Date of Patent: May 17, 1988
    Assignees: Ciba-Geigy Corporation, Plantorgan Werk Heinrich G.E. Christensen KG
    Inventors: Hans Fritz, Johannes Dodt, Ursula Seemuller, Ernst Fink
  • Process for the preparation of desulfatohirudins
    Patent number: 4654302
    Abstract: The present invention relates to desulfatohirudins, to the preparation thereof, to pharmaceutical compositions containing these compounds, and to the use thereof.The desulfatohirudins of this invention correspond to hirudin in biological activity and are therefore particularly useful for inhibiting blood clotting.
    Type: Grant
    Filed: November 21, 1984
    Date of Patent: March 31, 1987
    Assignees: Ciba-Geigy Corporation, Plantorgan Werk Heinrich G.E. Christensen KG
    Inventors: Hans Fritz, Johannes Dodt, Ursula Seemuller, Ernst Fink
  • Modified protease inhibitors, process for their preparation, and pharmaceutical compositions prepared therefrom
    Patent number: 4636489
    Abstract: The invention relates to novel, modified eglins B and C, to the preparation thereof, and to pharmaceutical compositions which contain these compounds. Compared with eglin B and C, the modification consists in a terminal shortening. The compounds of the invention can be prepared e.g. by limited enzymatic proteolysis of elgins or by peptide synthesis.
    Type: Grant
    Filed: July 6, 1984
    Date of Patent: January 13, 1987
    Assignees: Plantorganwerk KG, Ciba-Geigy Corporation
    Inventors: Ursula Seemuller, Johannes Dodt, Hans Fritz